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| 1 | 蛋白酶激活受体2在载脂蛋白E缺陷小鼠的血管炎症和动脉粥样硬化中发挥关键作用显示文摘凝血系统与血管炎症密切相关,尽管其潜在机制仍不清楚。最近的研究结果表明,蛋白酶激活受体(protease-activated receptor,PAR)2——活化因子X(activated factor X,FXa)的主要受体之一——在血管细胞和白细胞中均有表达,这提示PAR-2可能参与炎症性疾病的发病机制。 | Hara T Phuong PT Fukuda D Yamaguchi K Murata C Nishimoto S Yagi S Kusunose K Yamada H Soeki T Wakatsuki T Imoto I Shimabukuro M Sata M 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，6： | 11 |
| 2 | Biofilm three-dimensional architecture influences in situ pH distribution pattern on the human enamel surface显示文摘To investigate how the biofilm three-dimensional(3D) architecture influences in situ pH distribution patterns on the enamel surface. Biofilms were formed on human tooth enamel in the presence of 1% sucrose or 0.5% glucose plus 0.5% fructose. At specific time points, biofilms were exposed to a neutral pH buffer to mimic the buffering of saliva and subsequently pulsed with 1% glucose to induce re-acidification. Simultaneous 3D pH mapping and architecture of intact biofilms was performed using two-photon confocal microscopy. The enamel surface and mineral content characteristics were examined successively via optical profilometry and microradiography analyses. Sucrose-mediated biofilm formation created spatial heterogeneities manifested by complex networks of bacterial clusters(microcolonies). Acidic regions(pH<5.5) were found only in the interior of microcolonies,which impedes rapid neutralization(taking more than 120 min for neutralization). Glucose exposure rapidly re-created the acidic niches, indicating formation of diffusion barriers associated with microcolonies structure. Enamel demineralization(white spots),rougher surface, deeper lesion and more mineral loss appeared to be associated with the localization of these bacterial clusters at the biofilm-enamel interface. Similar 3D architecture was observed in plaque-biofilms formed in vivo in the presence of sucrose. The formation of complex 3D architectures creates spatially heterogeneous acidic microenvironments in close proximity of enamel surface, which might correlate with the localized pattern of the onset of carious lesions(white spot like) on teeth. | Jin Xiao Anderson T Hara Dongyeop Kim Domenick T Zero Hyun Koo Geelsu Hwang | 2017 | International Journal of Oral Science2017，9，2： | 4 |
| 3 | Efficacy of equator of rings in an experimental rabbit study显示文摘 | Hara T Sakanishi K Yamada Y | 1995 | Arch Ophthalmol1995，1065，： | 2 |
| 4 | 尿酸是正常高值血压发展为高血压的一个重要危险标志物显示文摘正常高值血压常发展为高血压,是一个与心血管病和脑卒中高死亡率和高发病率相关的事件。然而,正常高值血压发展成高血压的危险因素仍不清楚。研究者采用年龄(52.1±11.0)岁日本成年高血压患者3584例(2081例为男性)的资料进行前瞻性群体研究,研究对象在2004年被发现处于正常高值血压阶段,并在2009年重新进行检查。 | 黄洁 叶鹏 Kuwabara M Hisatome I Niwa K Hara S Roncal-Jimenez CA Bjornstad P Nakagawa T Andres-Hernando A Sato Y Jensen T Garcia G Rodriguez-Iturbe B Ohno M Lanaspa MA Johnson RJ | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 5 | Chronic neutrophilic leukemia with congenital Robertsonian translocation successfully treated with allogeneic bone marrow transplantation in a young man 显示文摘 | Goto H Hara T Tsurumi H | 2009 | Inter Med2009，48，7： | 1 |
| 6 | The lipoprotein lipase activator, NO-1886, suppresses fal accumulation and insulin resistance in rats fed a high-fat diet显示文摘 | KUSUNOKI M HARA T TSUTSUMI K | 2000 | Diabetologia2000，43，7： | 1 |
| 7 | Postischemic infusion of sivelestat sodium hydrate, a selective neutrophiI elastase inhibitor,protects against myocardial stunning in swine显示文摘 | Akiyama D Hara T Yoshitomi O Maekawa T Cho S Sumika wa K | 2010 | J Anesth2010，24，： | 1 |
| 8 | Total and face prostate-specific antigen indexes in prostate cancer screening:value and limitation for Japanese populations显示文摘 | Hara N Kitamura Y Saito T | 2006 | Asian J Androl2006，8，4： | 1 |
| 9 | Continuous arterial infusion of protease inhibitor with supplementary therapy for the patients Withsevere acute pan - creat it is Clinical effect of arterial injection of ulinastin 显示文摘 | Matsukawa H Hara A Ito T | 1998 | Nippon Shokakib - yo Gakkai Zasshi1998，95，： | 1 |
| 10 | Cu2O as a photocatalyst for overall water splitting under visible light irradiation 显示文摘 | Hara M Kondo T Komoda M | 1998 | Chem Commun1998，3，： | 1 |
| 11 | Transplantation of human neural stern cells exerts neuroprotection in a rat model of Parkinson's disease显示文摘 | Yasuhara T Matsukawa N Hara K | 2006 | J Neurosci2006，26，12： | 1 |
| 12 | Matrix metalloproteinas- es 2 and 9 in oral squamous cell carcinomas: manifesta- tion and localization of their activity显示文摘 | Kato K Hara A Kuno T | 2005 | J Cancer Res Clin Oncol2005，131，6： | 1 |
| 13 | Inhibitory effect of gabapentin on N-methyl-D-aspar- tate receptors expressed in Xenopus oocytes 显示文摘 | Hara K Sata T | 2007 | Acta Anaesthesiol Scand2007，51，1： | 1 |
| 14 | The soybean beta-eonglyeinin beta 51-63 fragment suppresses appetite by stim- ulating choleeystokinin release in rats显示文摘 | Nishi T Hara H Asano K | 2003 | J Nutr2003，133，： | 1 |
| 15 | Cooling performance of solar cell driven, thermoelectric cooling prototype headgear显示文摘 | Hara T Azuma H | 1998 | Applied Thermal Engineering1998，18，： | 1 |
| 16 | Two short segments of Smad 3 are important for specific interaction of Smad 3 with c-Ski and SnoN显示文摘 | Miznide M Hara T Furuya T | 2003 | J Biol Chem2003，278，1： | 1 |
| 17 | EBV gene expression in an NPC-related tumour显示文摘 | Hitt M M Allday M J Hara T | 1989 | EMBO J1989，8，9： | 1 |
| 18 | A prospective randomized comparison of diagnostic efficacy between transperineal and transreetal 12-core prostate biopsy 显示文摘 | TAKENAKA A HARA R ISHIMURA T | 2008 | Prostate Cancer Prostatic Dis2008，11，2： | 1 |
| 19 | CD9 is a surface marker on mouse and rat male germline stem cells 显示文摘 | KANATSU-SHINOHARA M TOYOKUNI S SHINO- HARA T | 2004 | Biol Reprod2004，70，1： | 1 |
| 20 | Impact of preoperative hemoglobin level on survival of non-small cell lung cancer patients 显示文摘 | Tomita M Shimizu T Hara M | 2008 | Anticancer Res2008，28，3： | 1 |
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