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| 1 | Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C显示文摘AIM: To investigate the factors other than fibrosis stage correlating with acoustic radiation force impulse(ARFI) elastograpy in chronic hepatitis C. METHODS: ARFI elastograpy was performed in 108 consecutive patients with chronic hepatitis C who underwent a liver biopsy. The proportion of fibrosis area in the biopsy specimens was measured by computerassisted morphometric image analysis. RESULTS: ARFI correlated significantly with fibrosis stage(β = 0.1865, P < 0.0001) and hyaluronic acid levels(β = 0.0008, P = 0.0039) in all patients by multiple regression analysis. Fibrosis area correlated significantly with ARFI by Spearman's rank correlation test but not by multiple regression analysis. ARFI correlated significantly with body mass index(BMI)(β =-0.0334, P = 0.0001) in F 0 or F 1, with γ-glutamyltranspeptidase levels(β = 0.0048, P = 0.0012) in F 2, and with fibrosis stage(β = 0.2921, P = 0.0044) and hyaluronic acid levels(β = 0.0012, P = 0.0025) in F 3 or F 4. The ARFI cutoff value was 1.28 m/s for F ≥ 2, 1.44 m/s for F ≥ 3, and 1.73 m/s for F 4. CONCLUSION: ARFI correlated with fibrosis stage and hyaluronic acid but not with inflammation. ARFI was affected by BMI, γ-glutamyltranspeptidase, and hyaluronic acid in each fibrosis stage. | Toru Nishikawa Senju Hashimoto Naoto Kawabe Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Yuko Mizuno Hiroaki Shimazaki Toshiki Kan Kazunori Nakaoka Yuka Takagawa Masashi Ohki Naohiro Ichino Keisuke Osakabe Kentaro Yoshioka | 2014 | World Journal of Gastroenterology2014，20，5： | 7 |
| 2 | A new index for non-invasive assessment of liver fibrosis显示文摘AIM:To construct and evaluate a new non-invasive fibrosis index for assessment of the stage of liver f ibrosis. METHODS:A new f ibrosis index (Fibro-Stiffness index) was developed in 165 of 285 patients with chronic hepatitis C, and was validated in the other 120 patients where liver biopsy was performed. Its usefulness was compared with liver stiffness (LS) measured by FibroScan, the aminotransferase-to-platelet ratio index, the Forns index and the FibroIndex. RESULTS: The Fibro-Stiffness index consists of LS,platelet count and prothrombin time. The values of the Fibro-Stiffness index differed signif icantly between neighboring f ibrosis stages except F0-F1. The area under the receiver operating characteristics curves of the Fibro-Stiffness index for prediction of F≥2 (0.90), F≥ 3 (0.90) and F= 4(0.92) in the estimation group and those for F≥ 3 (0.93) and F =4 (0.97) in the validation group were the highest among the 5 methods examined. The accuracy of the Fibro-Stiffness index had highest values for F≥2, F≥3 and F=4 in both the estimation and validation groups. The diagnostic performance for F= 4 was improved by a combination of the Fibro-Stiffness index with serum hyaluronic acid level. CONCLUSION: The Fibro-Stiffness index was constructed and validated. It showed superior diagnostic performance to other indices for F ≥ 2,3 and 4. | Naohiro Ichino Keisuke Osakabe Toru Nishikawa Hiroko Sugiyama Miho Kato Shiho Kitahara Senju Hashimoto Naoto Kawabe Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Yuko Arima Hiroaki Shimazaki Koji Suzuki Kentaro Yoshioka | 2010 | World Journal of Gastroenterology2010，16，38： | 7 |
| 3 | Spinous process-splitting laminoplasty using hydroxyapatite spinous process spacer显示文摘 | Nakano K Harata S Suetsuna F | 1992 | Spine (Phila Pa 1976)1992，17，3： | 1 |
| 4 | Expression of ECRG4 is an independent prognostic factor for poor survivalin patients with esophageal squamous cell carcinoma显示文摘 | Yoichiro Mori Hideyuki Ishiguro Yoshiyuki Kuwabara Masahiro Kimura Akira Mitsui Horoki Kurehara Ryota Mori Keisuke Tomoda Ryo Ogawa Takeyasu Katada Koshiro Harata Yoshitaka Fujii | 2007 | Oncology Reports2007，，： | 1 |
| 5 | Formation of protein crystals (orthorhombic lysozyme) in quasi-micro- gravity environment obtained by superconducting magnet 显示文摘 | Yin D C Wakayama N I Harata K | 2004 | J Cryst Growth2004，270，1： | 1 |
| 6 | Cryopreservation of zygotic embryos of a Japariese terreslrial orchid (Bletilla striata )by vitrification 显示文摘 | Ishikawa K Harata R M Sakai A | 1997 | Plant cell reports1997，16，： | 1 |
| 7 | Class 1inte-gron containing metallo-beta-lactamase gene blaVIM-2 in Pseudomonas aeruginosa clinical strains isolated in Japan显示文摘 | Yatsuyanagi J Saito S Harata S | | 0，，02： | 1 |
| 8 | Cryopreservation of zygotic embryos of Japanese terrestrial orchid (Bletilla striata) by vitrification显示文摘 | Ishikawa K Harata K Mii M | | 0，，： | 1 |
| 9 | Crystallographic analysis of the thermal motion of the inclusion complex of cyclomaltoheptaose (β-cyclodextrin) with hexamethylenetetramine显示文摘 | Harata K | 2003 | Carbohydr Res2003，338，： | 1 |
| 10 | A high-speed multiplier using a redundant binary tree 显示文摘 | | 1987 | IEEE Journal of Solid-State Circuits1987，122，1： | 1 |
| 11 | SOD activities of the copper complexes with tripodal polypyridylamine ligands having a hydrogen bonding sites显示文摘 | Koichiro Jitsukawa Manabu Harata Hidekazu Arii | 2001 | Inorg Chim Acta2001，324，12： | 1 |
| 12 | Assessment of nu- tritional status of patients with hepatitis C virus-related liver cirrhosis 显示文摘 | KAWABE N HASHIMOTO S HARATA M | 2008 | Hepatalogy Researc12008，38，： | 1 |
| 13 | Run-down of GABA-A response under experimental ischemia in acutely dissociated CA1 pyramidal neurones of the rat 显示文摘 | Jie W Ishibashi H | 1997 | J Physiol1997，500，3： | 1 |
| 14 | The case of a patient with treatment-refractory obsessive-compulsive disorder operated by stereotactic bilateral cingulotomy显示文摘 | Harata M | 2004 | Neurol Neurochir Pol2004，38，6： | 1 |
| 15 | Osteoarthritis of atlanto - axial joint显示文摘 | Harata S Tohno S Kawagishi T | 1981 | Inter Orthop1981，5，： | 1 |
| 16 | Lead perovskite relaxor-based low-loss ceramic dielectric for high-voltage ceramic capacitors显示文摘 | Yamashita Y Harata M | 1991 | Jpn J Appl Phys1991，30，： | 1 |
| 17 | Mul-tiple functions of CXCL12 in a syngeneic model of breast cancer显示文摘 | WILLIAMS S A HARATA LEE Y COMERFORD I | 2010 | Mol Cancer2010，9，250： | 1 |
| 18 | Low firing and high dielectric constant X7R ceramic dielectric for multilayer capacitor based on relaxor and barium titanat composite显示文摘 | Furakawa O Harata M Imai M | 1991 | J Mater Sci1991，126，： | 1 |
| 19 | Treatment for fractures of the odontoid process 显示文摘 | Echigoya N Harata S Ueyama K | 2003 | J Bone Joint Surg (Br)2003，85，： | 1 |
| 20 | Osteoarthritis of the atlantoaxial joint 显示文摘 | Harata S Tolom S Kawagishi T | 1981 | Intemat Orthop1981，5，： | 1 |
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