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| 1 | Transcriptome analysis of ankylosed primary molars with infraocclusion显示文摘Primary molar ankylosis with infraocclusion can retard dental arch development and cause dental asymmetry. Despite its widespread prevalence, little is known about its molecular etiology and pathogenesis. To address this, RNA sequencing was used to generate transcriptomes of furcal bone from infraoccluded(n = 7) and non-infraoccluded(n = 9) primary second molars, all without succeeding biscuspids. Of the 18 529 expressed genes, 432(2.3%) genes were differentially expressed between the two groups(false discovery rate < 0.05). Hierarchical clustering and principal component analysis showed clear separation in gene expression between infraoccluded and non-infraoccluded samples. Pathway analyses indicated that molar ankylosis is associated with the expression of genes consistent with the cellular inflammatory response and epithelial cell turnover. Independent validation using six expressed genes by immunohistochemical analysis demonstrated that the corresponding proteins are strongly expressed in the developing molar tooth germ, in particular the dental follicle and inner enamel epithelium. The descendants of these structures include the periodontal ligament, cementum, bone and epithelial rests of Malassez;tissues that are central to the ankylotic process.We therefore propose that ankylosis involves an increased inflammatory response associated with disruptions to the developmental remnants of the dental follicle and epithelial rests of Malassez. | Annie Tong Yuh-Lit Chow Katie Xu Rita Hardiman Paul Schneider Seong-Seng Tan | 2020 | International Journal of Oral Science2020，12，1： | 3 |
| 2 | A new class of mere-brane-bound chemokine with a CX3C motif显示文摘 | Bazan JF Bacoon KB Hardiman G | 1997 | Nature1997，385，： | 1 |
| 3 | Polycystic ovary syndrome and endometrial cancer 显示文摘 | Navaratnarajah R Pillay OC Hardiman P | 2008 | Semin Reprod Med2008，26，1： | 1 |
| 4 | Prognostic factors in ALS a critical review显示文摘 | Chio A Logroscino G Hardiman O | 2009 | Amyotroph Lateral Scler2009，10，56： | 1 |
| 5 | The Oxfordshire Community Stroke Project classification correlation with imaging,associated complications,and predication of outcome in actue ischemic stroke显示文摘 | Pittock SJ Meldrum D Hardiman D | 2003 | Journal of Stroke Cerebrovascular Diseases2003，12，1： | 1 |
| 6 | Polycytic ovarg syndrome andendometrial carcinma显示文摘 | Hardiman P Pillag 0 C Atioma W | 2003 | Lancet2003，361，： | 1 |
| 7 | Isolation, characteriza- tion and chromosomal localization of human WNT10B 显示文摘 | Hardiman G Kastelein RA Bazan JF | 1997 | Cytogenet Cell Genet1997，77，34： | 1 |
| 8 | A family of human receptors structurally related to Drosophila 显示文摘 | Rock EL Hardiman G Timans JC | 1998 | Proc Natl Acad Sci1998，95，： | 1 |
| 9 | Polycytic ovarg syndrome and endometrial carcinma显示文摘 | Hardiman P Pillag OS Atioma W | | 0，，9389： | 1 |
| 10 | Anti-NMDA receptor encephalitis: an important differential diagnosis in psychosis显示文摘 | Barry H Hardiman O Healy DG | 2011 | Br J Psychiatry2011，199，6： | 1 |
| 11 | A family,of human receptors structurally related to Drosophila Toll显示文摘 | Rock FL Hardiman G Timans JC | 1998 | Proc Nall Acad Sci USA1998，95，2： | 1 |
| 12 | Polycystic ovary syndrome and endometrial carcinoma 显示文摘 | Hardiman P Pillay OC Atiomo W | 2003 | Lancet2003，，： | 1 |
| 13 | Neuropathic Find- ings in Oculopharyngeal Muscular Dystrophy显示文摘 | Hardiman O Halperin JJ Farrell MA | 1993 | Archives Neu- rology1993，50，： | 1 |
| 14 | Pathways for degradation of lignin in bacteria and fungi 显示文摘 | BUGG T D AHMAD M HARDIMAN E M | 2011 | Nat Prod Rep2011，28，12： | 1 |
| 15 | Saerospinous vault suspension and abdominal eolposaeropexy: success rates and complications 显示文摘 | Hardiman PJ Drutz HP | 1996 | Am J Obstet Gyneeol1996，，： | 1 |
| 16 | Polycystic endometrial cancinoma显示文摘 | Hardiman drome and P Pillay OC Atiomo W | | Lancet0，，9371： | 1 |
| 17 | A family of human receptors structurally related to Drosophila Toll显示文摘 | Rock A Hardiman G Timans JC | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 18 | Clinical diagnosis and management ofamyotrophic lateral scleosis显示文摘 | Hardiman O van den Berg LH Kieman MC | | 0，，11： | 1 |
| 19 | A new class of membrane-bound chemokine with a CX3C motif显示文摘 | Bazan JF Bacon KB Hardiman G | 1997 | Nature1997，385，6617： | 1 |
| 20 | A family of human receptors structurally related to Drosophila toll显示文摘 | Rock F L Hardiman G Timans J C | 1998 | Proc Acad Sic USA1998，95，2： | 1 |
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