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| 1 | role of the normal gut microbiota显示文摘Relation between the gut microbiota and human health is being increasingly recognised. It is now well established that a healthy gut flora is largely responsible for overall health of the host. The normal human gut microbiota comprises of two major phyla, namely Bacteroidetes and Firmicutes. Though the gut microbiota in an infant appears haphazard, it starts resembling the adult flora by the age of 3 years. Nevertheless, there exist temporal and spatial variations in the microbial distribution from esophagus to the rectum all along the individual's life span. Developments in genome sequencing technologies and bioinformatics have now enabled scientists to study these microorganisms and their function and microbehost interactions in an elaborate manner both in health and disease. The normal gut microbiota imparts specific function in host nutrient metabolism, xenobiotic and drug metabolism, maintenance of structural integrity of the gut mucosal barrier, immunomodulation, and protection against pathogens. Several factors play a role in shaping the normal gut microbiota. They include(1) the mode of delivery(vaginal or caesarean);(2) diet during infancy(breast milk or formula feeds) and adulthood(vegan based or meat based); and(3) use of antibiotics or antibiotic like molecules that are derived from the environment or the gut commensal community. A major concern of antibiotic use is the long-term alteration of the normal healthy gut microbiota and horizontal transfer of resistance genes that could result in reservoir of organisms with a multidrug resistant gene pool. | Sai Manasa Jandhyala Rupjyoti Talukdar Chivkula Subramanyam Harish Vuyyuru Mitnala Sasikala D Nageshwar Reddy | 2015 | World Journal of Gastroenterology2015，21，29： | 187 |
| 2 | SDN在IP网络演进中的作用显示文摘Web已经改变了一切。新的服务每天都在出现,并且有些服务一夜之间就能够获得巨大的用户量,导致网络中的使用方式和流量模式完全难以预测。过去所建立的基础设施难以适应这些新变化,为了满足这些需求,网络必须能够快速、自动、经济地适应新的变化。软件定义网络(SDN)和网络功能虚拟化(NFV)就是其中两个能灵活地使能上述需求的技术。本文描述了SDN在IP网络领域中所起的作用(包括在实现NFV方面的关键作用),并介绍了关于网络如何引入SDN和NFV的场景和多个使用案例,用于说明SDN和NFV如何使得网络更加敏捷、可编程、优化地支持业务和用户的特殊需求。 | Mark M.Clougherty Christopher A.White Harish Viswanathan Colin L.Kahn | 2014 | 电信科学2014，30，5： | 25 |
| 3 | Sperm membrane modulation by Sapindus mukorossi during sperm maturation显示文摘Aim:TO observe the alterations in the biochemical and biophysical changes in the sperm membrane during sperm maturation in male rats treated with the water extract of the fruit pericarp of S.mukorossi.Methods:Adult male Sprague-Dawley rats were gavaged the aqueous extract of the fruit pericarp of S.mukorossi at a dose of 50mg/kg/dfor45days.On day46,the sperm parameters were observed in idfferent sections of the epididymis and the sperm superoxide dismutase and the lipid peroxidation was edtermined and compared with the controls.The testis and epidiymis were routinely prepared for histological examination under the light microscope.Results:No significant differences in the sperm number and morphology were observed between the control and reated groups.However,a significant inhibition(P<0.05-0.01)of sperm motility in the caput,corpus and cauda regions of the epididymis was seen in the treated group.No significant histopathological changes were found in the testis and epididymis.Theimportant finding was that in the treated animals,the spermatozoa showed an abnormal distribution of the superoxide dismutase activity,being minimum in the caput and maximum in the corpus,which was just opposite to that of the controls.Conclusion:The study provides a unique observation where the plant extract alters the sperm membrane physiology without change the testicular and epididymal morphology. | Manish Nivsarkar Neeta Shrivastava Manoj Patel Harish Padh Cherian Bapu | 2002 | Asian Journal of Andrology2002，4，3： | 14 |
| 4 | Copy number variations are progressively associated with the pathogenesis of colorectal cancer in ulcerative colitis显示文摘AIM: To evaluate the association of known copy number variations(CNVs) in ulcerative colitis(UC) progressing to colorectal cancer.METHODS: Microsatellite instability analysis using the National Cancer Institute's panel of markers, and CNV association studies using Agilent 2 × 105 k arrays were done in tissue samples from four patient groups with UC: those at low risk(LR) or high risk of developing colorectal cancer, those with premalignant dysplastic lesions, and those with colitis-associated colorectal cancer(CAC). DNA from tissue samples of these groups were independently hybridized on arrays and analyzed. The data obtained were further subjected to downstream bioinformatics enrichment analysis to examine the correlation with CAC progression.RESULTS: Microarray analysis highlighted a progressive increase in the total number of CNVs [LR(n = 178) vs CAC(n = 958), 5.3-fold], gains and losses [LR(n = 37 and 141) vs CAC(n = 495 and 463), 13.4- and 3.3-fold, respectively], size [LR(964.2 kb) vs CAC(10540 kb), 10.9-fold] and the number of genes in such regions [LR(n = 119) vs CAC(n = 455), 3.8-fold]. Chromosomewise analysis of CNVs also showed an increase in the number of CNVs across each chromosome. There were 38 genes common to all four groups in the study; 13 of these were common to cancer genes from the Genetic Disease Association dataset. The gene set enrichment analysis and ontology analysis highlighted many cancerassociated genes. All the samples in the different groupswere microsatellite stable.CONCLUSION: Increasing numbers of CNVs are associated with the progression of UC to CAC, and warrant further detailed exploration. | Bhadravathi Marigowda Shivakumar Harish Rotti Thanvanthri Gururajan Vasudevan Aswath Balakrishnan Sanjiban Chakrabarty Ganesh Bhat Lakshmi Rao Cannanore Ganesh Pai Kapaettu Satyamoorthy | 2015 | World Journal of Gastroenterology2015，21，2： | 10 |
| 5 | 高效液相色谱-荧光检测法测定人血浆中的匹伐他汀(英文)显示文摘Pitavastatin belongs to the class of coenzyme A reductase inhibitors.Very few methods of assaying pitavastatin from human plasma are available in literature.An analytical method is presented for the determination of the drug from human plasma making use of the fluorescent property of the drug.The drug is extracted from plasma using ethyl acetate under neutral condition and then analyzed by reversed-phase high performance liquid chromatography(HPLC) with fluorescence detection(λEx 245 nm;λEm 420 nm).Analysis of pitavastatin was carried out on a C18 HPLC column using a gradient flow of mobile phase(0.01 mol/L monobasic potassium phosphate(pH 3.20)-acetonitrile,63:37,v/v).Fluorescein isothiocyanate was used as internal standard.The dynamic range of assay was 3 to 50 ng/mL.The intraday precision was less than 10% and accuracy ranged from 95.2% to 112.6%.The same for interday check was less than 12% and 92.8% to 105.1%,respectively.The drug was found to be stable under the assay conditions.The developed method is simple,precise,accurate,and stable.This indicates that it can be applied to routine analysis of this drug in human subjects where there are large numbers of samples without the need of specialized instruments like column switching. | OJHA Ashwini GUTTIKAR Swati VAYEDA Chintan PADH Harish | 2007 | 色谱2007，25，5： | 8 |
| 6 | Analysis and use of fuzzy intelligent technique for navigation of humanoid robot in obstacle prone zone显示文摘With the increasing use of humanoid robots in several sectors of industrial automation and manufacturing, navigation and path planning of humanoids has emerged as one of the most promising area of research. In this paper, a navigational controller has been developed for a humanoid by using fuzzy logic as an intelligent algorithm for avoiding the obstacles present in the environment and reach the desired target position safely. Here, the controller has been designed by careful consideration of the navigational parameters by the help of fuzzy rules. The sensory information regarding obstacle distances and bearing angle towards the target are considered as inputs to the controller and necessary velocities for avoiding the obstacles are obtained as outputs. The working of the controller has been tested on a NAO humanoid robot in V-REP simulation platform. To validate the simulation results, an experimental platform has been designed under laboratory conditions, and experimental analysis has been performed.Finally, the results obtained from both the environments are compared against each other with a good agreement between them. | Asita Kumar Rath Dayal R.Parhi Harish Chandra Das Manoj Kumar Muni Priyadarshi Biplab Kumar | 2018 | Defence Technology(防务技术)2018，14，6： | 7 |
| 7 | Bubbly shock propagation as a mechanism of shedding in separated cavitating flows显示文摘Stable attached partial cavitation in separated flows can transition to cloud shedding, and the mechanism of transition has been attributed to the presence of a re-entrant liquid jet. Our findings have revealed the presence of propagating bubbly shock waves as an alternative dominant mechanism of shedding when the compressibility of the bubbly mixture is appreciable. In the present paper, we discuss dynamics associated with these bubbly shock waves, interaction of shock waves with obstacles in their path, and means to manipulate their properties to control the shedding process by non-condensable gas injection. | Harish Ganesh Simo A.Makiharju Steven L.Ceccio | 2017 | Journal of Hydrodynamics2017，29，6： | 5 |
| 8 | Ebola virus disease: past, present and future显示文摘Ebola virus disease is one of the most deadly ailments known to mankind due to its high mortality rate(up to 90%) accompanying with the disease. Ebola haemorrhagic fever(EHF) is an infectious disease of animal that can be transmitted to both human and non-human primates. The first epidemic of EHF occurred in 1976 in the Democratic Republic of the Congo. The incubation period of ebola is less than 21 days. Ebola virus infections are depicted by immune suppression and a systemic inflammatory response that leads to damage of the vascular, coagulation and immune systems, causing multi-organ failure and shock. Five genetically distinct members of the Filoviridae family responsible for EHF are as follows: Zaire ebolavirus, Sudan ebolavirus, C?te d'Ivoire ebolavirus, Bundibugyo ebolavirus and Reston ebolavirus. The ongoing 2014 West Africa ebola epidemic has been considered as the most serious panic in the medical field with respect to both the number of human cases and death toll. The natural host for ebola virus is unknown, thus it is not possible to carry out programs to regulate or abolish virus from transmission to people. The ebola virus infection provides little chance to develop acquired immunity causing rapid progression of the disease. It is pertinent to mention that at present, there is no antiviral therapy or vaccine that is helpful against ebola virus infection in humans. The impediment of EHF necessitates much better understanding of the epidemiology of the disease, particularly the role of wildlife, as well as bats, in the spread of ebola virus to humans. | Harish Rajak Deepak Kumar Jain Avineesh Singh Ajay Kumar Sharma Anshuman Dixit | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，5： | 4 |
| 9 | High Q-factor controllable phononic modes in hybrid phononic–dielectric structures显示文摘Phonon polariton resonances in the mid-infrared spectral range demonstrate properties superior to noble metal-based plasmonics,owing to smaller dissipative loss and better field confinement.However,a conventional way to excite the localized phonon resonance involves ion etching,which reduces the attainable quality factors(Q-factors)of the resonators.We show that by introducing a deep subwavelength layer of dielectric gratings on a phononic substrate,localized dipolar resonance and higher order modes with high Q-factors 96 and 195,respectively,can be excited.We further demonstrate,via experiments and simulations,that the resonant wavelength and field confinement can be controlled by coupling the localized hybrid mode with propagating surface phonon-polaritons.We also observed for the first time the coupling between a localized dipolar mode and a propagating higher-order surface phonon-polariton mode.The results will be useful in designing on-chip,low-loss,and highly integrated phononic devices in the infrared spectral domain. | Bo Qiang Alexander M.Dubrovkin Harish N.S.Krishnamoorthy Qian Wang Cesare Soci Ying Zhang Jinghua Teng Qi Jie Wang | 2019 | Advanced Photonics2019，1，2： | 4 |
| 10 | Optimization of fused deposition modeling process parameters using a fuzzy inference system coupled with Taguchi philosophy显示文摘 | Saroj Kumar Padhi Ranjeet Kumar Sahu S. S. Mahapatra Harish Chandra Das Anoop Kumar Sood Brundaban Patro A. K. Mondal | 2017 | Advances in Manufacturing2017，5，3： | 4 |
| 11 | Predicting the presence of adenomatous polyps during colonoscopy with National Cancer Institute Colorectal Cancer Risk-Assessment Tool显示文摘AIM To evaluate the National Cancer Institute(NCI)Colorectal Cancer(CRC)Risk Assessment Tool as a predictor for the presence of adenomatous polyps(AP) found during screening or surveillance colonoscopy.METHODS This is a retrospective single center observational study.We collected data of adenomatous polyps in each colonoscopy and then evaluated the lifetime CRC risk.We calculated the AP prevalence across risk score quintiles,odds ratios of the prevalence of AP across risk score quintiles,area under curves(AUCs)and Youden’s indexes to assess the optimal risk score cut off value for AP prevalence status.RESULTS The prevalence of AP gradually increased throughout the five risk score quintiles:i.e.,27.63%in the first and 51.35%in the fifth quintile.The odd ratios of AP prevalence in the fifth quintile compared to the first and second quintile were 2.76[confidence interval(CI):1.71-4.47]and 2.09(CI:1.32-3.30).The AUC for all patients was 0.62(CI:0.58-0.66).Youden’s Index indicated the optimal risk score cutoff value discriminating AP prevalence status was 3.60.CONCLUSION Patients with the higher NCI risk score have higher risk of AP and subsequent CRC;therefore,measures to increase the effectiveness of CRC detection in these patients include longer withdrawal time,early surveillance colonoscopy,and choosing flexible colonoscopy over other CRC screening modalities. | Hassan Tariq Muhammad Umar Kamal Harish Patel Ravi Patel Muhammad Ameen Shehi Elona Maram Khalifa Sara Azam Aiyi Zhang Kishore Kumar Ahmed Baiomi Danial Shaikh Jasbir Makker | 2018 | World Journal of Gastroenterology2018，24，34： | 3 |
| 12 | Comparative study of the results of compound tibial shaft fractures treated by Ilizarov ring fixators and limb reconstruction system fixators显示文摘Purpose: llizarov ring fixator and limb reconstruction system (LRS) fixators have been used in the management of complex tibial fractures with severe soft tissue injuries, compound tibial fractures, and infected tibial nonunion for which conventional internal fixation cannot be contemplated. Fracture union and distraction osteogenesis can be done simultaneously with these external fixators, allowing early weight bearing. Several previous studies have shown almost equal results of rail and ring fixators for the compound tibial shaft fractures. Thus we performed a prospective study to evaluate the union rate, functional outcome and amount of limb lengthening after the treatment of compound tibial shaft fractures with or without infected nonunion by ring or LRS fixators. Methods: This prospective study was done at Sarojini Naidu Medical College and Hospital, Agra, India and included 32 patients of compound tibial shaft fractures with or without infected nonunion. There were 26 males and 6 females and the average age was 40 years. Patients were randomly divided into two groups (n - 16 for each): one underwent llizarov fixation and the other received LRS fixation. Cases were followed up for 3-24 months, 6 months on average from September 2012 to October 2014. Functional and radiological outcomes were assessed using the Association for the Study and Application of Methods of llizarov (ASAMI) criteria for both rail and ring fixators. Results: Union was achieved in all cases. Radiological outcome was found excellent in 68.75%, good in 18.75% and fair in 12.50% of cases treated by rail fixators whereas it was excellent in 56.25%, good in 18.75%, fair in 12.50% and poor in 12.50% of cases treated by ring fixators. Functional result was satis- factory in 75.00% of cases treated by rail fixator and 68.75% of cases treated by ring fixators whereas the corresponding rate of unsatisfactory was 25.00% vs. 31.25%. Conclusion: In our short-term assessment, LRS fixators show a better result than llizarov fixators in terms of fracture union and functional outcome with soft tissue care and limb length. | Chandra Prakash Pal Harish Kumar Deepak Kumar K.S. Dinkar Vivek Mittal Naveen Kumar Singh | 2015 | Chinese Journal of Traumatology2015，18，6： | 3 |
| 13 | Prediction of daily sediment discharge using a back propagation neural network training algorithm:A case study of the Narmada River,India显示文摘Most of the studies on Artificial Neural Network (ANN) models remain restricted to smaller rivers and catchments. In this paper, an attempt has been made to correlate variability of sediment loads with rainfall and runoff through the application of the Back Propagation Neural Network (BPNN) algorithm for a large tropical river. The algorithm and simulation are done through MATLAB environment. The methodology comprised of a collection of data on rainfall, water discharge, and sediment discharge for the Narmada River at various locations (along with time variables) and application to develop a threelayer BPNN model for the prediction of sediment discharges. For training and validation purposes a set of 549 data points for the monsoon (16 June-15 November) period of three consecutive years (1996–1998) was used. For testing purposes, the BPNN model was further trained using a set of 732 data points of monsoon season of four years (2006–07 to 2009–10) at nine stations. The model was tested by predicting daily sediment load for the monsoon season of the year 2010–11. To evaluate the performance of the BPNN model, errors were calculated by comparing the actual and predicted loads. The validation and testing results obtained at all these locations are tabulated and discussed. Results obtained from the model application are robust and encouraging not only for the sub-basins but also for the entire basin. These results suggest that the proposed model is capable of predicting the daily sediment load even at downstream locations, which show nonlinearity in the transportation process. Overall, the proposed model with further training might be useful in the prediction of sediment discharges for large river basins. | Nibedita Bisoyi Harish Gupta Narayan Prasad Padhy Govind Joseph Chakrapani | 2019 | International Journal of Sediment Research2019，34，2： | 3 |
| 14 | Advances in molecular marker techniques and their applications in plant sciences显示文摘 | Milee Agarwal Neeta Shrivastava Harish Padh | 2008 | Plant Cell Reports2008，，4： | 3 |
| 15 | Experimental and numerical investigation of liquid-solid binary fluidized beds: Radioactive particle tracking technique and dense discrete phase model simulations显示文摘 | Varsha Jain Lipika Kalo Deepak Kumar Harish J. Pant Rajesh K. Upadhyay | 2017 | Particuology2017，15，4： | 3 |
| 16 | The p97 ATPase associates with EEA1 to regulate the size of early endosomes显示文摘AAA (与各种各样的细胞的活动联系 ATPase ) ATPase p97 对多样的底层蛋白质起作用在象膜熔化和 endoplasmic 那样的各种各样的细胞的过程参与联系蜂窝胃的降级(ERAD ) 。在膜熔化, p97 被认为在类比工作到相关 ATPase NSF (N-ethylmaleimide-sensitive 熔化蛋白质) ,它由拆卸支持膜熔化圈套建筑群。在 ERAD, p97 打乱从 ER 膜的错误褶层蛋白质到由 proteasome 便于他们的周转。这里,我们由建立早 endosomal autoantigen 在 endocytic trafficking 识别 p97 的新奇功能 1 (EEA1 ) 作为新 p97 底层。我们证明很少的 p97 对早内涵体膜局部性,在它经由 N 终端 C2H2 锌手指领域绑 EEA1 的地方。由 siRNA 或一个药理学禁止者的 p97 任何一个的抑制导致聚类和早内涵体的增大,它为 endocytic 货物与一个改变的 trafficking 模式被联系。机械学地,我们证明 p97 抑制在内涵体膜引起增加的 EEA1 自我协会。我们建议 p97 可以由管理 EEA1 的 oligomeric 状态调整早内涵体的尺寸。 | Harish N Ramanathan Yihong Ye | 2012 | Cell Research2012，22，2： | 3 |
| 17 | Seroprevalence of syphilis in patients attending a tertiary care hospital in Southern India显示文摘Objective:To report our experience with two tests,anti-cardiolipin antibody test[venereal disease reasearch laboratory(VDRL) test]and specific treponemal test(Treponema pallidum hemagglutination assay),used for screening antenatal,high risk cases and cases from sexually transmitted infection in a tertiary care hospital from January 2006 till December 2008.Methods:A total of 14639 samples received from various patient groups including antenatal cases,patients attending sexually transmitted disease(STD) clinic,blood donors and HIV positive patients were screened.Results:Among the 14639 samples collected,103 were positive by VDRL test.Of these 89 cases were confirmed by quantitative VDRL test and Treponema pallidum hemagglutination assay.The cumulative seroprevalence over two years was found to be 0.61%in this study.The syphilis seroprevalence reduced from 0.88%in 2006 to 0.40%in 2008.Among the various sub-populations studied,patients attending the sexually transmitted infection clinic showed a seroprevalence of 2.62%.The seroprevalence decreased significantly from 4.00%in 2006 to1.39%in 2008.Conclusions:Our study showed a statistically significant declining rate of syphilis in STD clinics as well as the overall seroprevalence.These findings could be interpreted as indicators of improved programmes for prevention and management of STDs. | Sadia Khan Godfred Antony Menezes Rahul Dhodapkar Belgode Narasimha Harish | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，12： | 2 |
| 18 | Hypoxia-Inducible Factor-1α Contributes to Brain Edema after Stroke by Regulating Aquaporins and Glycerol Distribution in Brain显示文摘 | Tetsuhiro Higashida Changya Peng Jie Li David Dornbos Kailing Teng Xiaohua Li Harish Kinni Murali Guthikonda Yuchuan Ding | 2011 | Current Neurovascular Research2011，，1： | 2 |
| 19 | Lung cancer metastasis to the gastrointestinal system:An enigmatic occurrence显示文摘Adenocarcinoma of the lung infrequently metastasizes to the gastrointestinal tract. We report a rare case of a 65-year-old male with no respiratory symptoms diagnosed with adenocarcinoma of the lung by histopathological examination of metastatic sites which included an ulcer in the gastric body and a mass in the rectum. Metastatic disease also involved the liver as well. Patient was treated with systemic chemotherapy but unfortunately expired five months after the diagnosis was made. | Kanthi Rekha Badipatla Niharika Yadavalli Trupti Vakde Masooma Niazi Harish K Patel | 2017 | World Journal of Gastrointestinal Oncology2017，9，3： | 2 |
| 20 | Studies on the decay characteristics of strontium aluminate phosphor on thermal treatment显示文摘 | Haranath D Virendra Shanker Harish Chander | 2002 | Material Chemistry and Phisics2002，，78： | 2 |
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