|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesis显示文摘Articular cartilage,which is mainly composed of collagen Ⅱ,enables smooth skeletal movement.Degeneration of collagen Ⅱ can be caused by various events,such as injury,but degeneration especially increases over the course of normal aging.Unfortunately,the body does not fully repair itself from this type of degeneration,resulting in impaired movement.Microfracture,an articular cartilage repair surgical technique,has been commonly used in the clinic to induce the repair of tissue at damage sites.Mesenchymal stem cells(MSC)have also been used as cell therapy to repair degenerated cartilage.However,the therapeutic outcomes of all these techniques vary in different patients depending on their age,health,lesion size and the extent of damage to the cartilage.The repairing tissues either form fibrocartilage or go into a hypertrophic stage,both of which do not reproduce the equivalent functionality of endogenous hyaline cartilage.One of the reasons for this is inefficient chondrogenesis by endogenous and exogenous MSC.Drugs that promote chondrogenesis could be used to induce self-repair of damaged cartilage as a non-invasive approach alone,or combined with other techniques to greatly assist the therapeutic outcomes.The recent development of human induced pluripotent stem cell(iPSCs),which are able to self-renew and differentiate into multiple cell types,provides a potentially valuable cell resource for drug screening in a“more relevant”cell type.Here we report a screening platform using human iPSCs in a multi-well plate format to identify compounds that could promote chondrogenesis. | Sheng-Lian Yang Erica Harnish Thomas Leeuw Uwe Dietz Erika Batchelder Paul SWright Jane Peppard Paul August Cecile Volle-Challier Francoise Bono Jean-Marc Herbert Juan Carlos Izpisua Belmonte | 2012 | Protein & Cell2012，3，12： | 3 |
| 2 | Estrogen receptor alpha regulates expression of the orphan receptor small heterodimer partner 显示文摘 | Lai K Harnish DC Evans MJ | 2003 | J Biol Chem2003，278，36： | 1 |
| 3 | Identification and characterization of genes differentially expressed in meningio-mas显示文摘 | Murphy M Pykett MJ Harnish P | 1993 | Cell Growth Differ1993，4，9： | 1 |
| 4 | Beneficial effects of estrogen treatment in the HLA-B27 transgenic rat model of inflammatory bowel disease显示文摘 | Harnish D C Albert L M Leat hurby Y | | 0，，01： | 1 |
| 5 | Improvement of physiochemical properties of the tetrahydroazepinoindole series of farnesoid X receptor (FXR) agonists: beneficial modulation of lipids in primates 显示文摘 | Lundquist JT Harnish DC Kim CY | 2010 | J Med Chem2010，53，： | 1 |
| 6 | High-temperature mechanical behavior and hot rolling of AA705X显示文摘 | HARNISH S F PADILLA H A DANTZIG J A BEAUDOIN A J GORE B E ROBERTSON I M | 2005 | Metallurgical and Materials Transactions A2005，36，： | 1 |
| 7 | Reactive and proactive aggression in school children and psychiatrically impaired chronically assaultive youth显示文摘 | Dodge KA Loehman JE Harnish J D | 1997 | J Abnorm Psychol1997，106，1： | 1 |
| 8 | Identification and characterization of genes differentially expressed in meningiomas显示文摘 | Murphy M Pykett MJ Harnish P | 1993 | Cell Growth Differ1993，4，： | 1 |
| 9 | Identification and charac- terization of genes differentially expressed in meningiomas 显示文摘 | MUPHY M PYKETF MJ HARNISH P et ol | 1993 | Cell Growth Differ1993，4，9： | 1 |
| 10 | Retinoic acid receptor 2 mRNA is elevated by retinoic acid in vivo in susceptible regions of mid -gestation mouse embryos 显示文摘 | Harnish DC Jiang H Soprano K J Kochhar DM Soprano DR | 1992 | Dev Dyn1992，194，3： | 1 |
| 11 | Identification and characterization of genes Differentially expressed in meningiomas显示文摘 | Murphy Pykett MJ Harnish P | 1993 | Cell Growth Differ1993，4，9： | 1 |
| 12 | Identification and characterization of genes differentially expressed in meningiomas显示文摘 | Murphy M Pykett M J Harnish P | 1993 | Cell Growth Differ1993，4，9： | 1 |
| 13 | The neurofibromatosis 2 (NF2) tumor suppressor gene encodes multiple alternatively spliced transcripts显示文摘 | Pykett M J Murphy M Harnish P R | 1994 | Hum Mol Genet1994，3，4： | 1 |
| 14 | LRP5 and Wnt signaling: a union made for bone显示文摘 | Johnson ML Harnish K Nusse R | 2004 | J Bone Miner Res2004，19，11： | 1 |
| 15 | Recent develop-ments in functional and structural imaging of aphasia recov-ery after stroke显示文摘 | Meinzer M Harnish S Conway T | 2011 | Aphasiology2011，25，3： | 1 |
| 16 | Risk factors for bile duct injury during laparoscopic cholecystectomy: a casecontrol study 显示文摘 | Kholdebarin R Boetto J Harnish JL | 2008 | Surg Innov2008，15，2： | 1 |
| 17 | Effect of migration pathway on travel time and survival of acoustic-tagged juvenile salmonids in the Columbia River Estuary显示文摘 | Harnish R A Johnson G E McMichael G A | 2012 | Transactions of the American Fisheries Society2012，，： | 1 |
| 18 | Reactive and proactive aggression inschool children and psychiatrically impaired chronically assaultive youth 显示文摘 | Dodge KA Lochman JE Harnish JD | 1997 | Abnorm Psychol1997，106，1： | 1 |
| 19 | Ankle dorsifiexion range of motion influence dynamic balance in individuals with chronic ankle instability 显示文摘 | Basenett CR Harnish MJ Wheeler TJ | 2013 | Int J Sport Phys Ther2013，8，2： | 1 |
| 20 | Risk factors for bile duct injury during laparoscopic cholecystectomy: a case-control study显示文摘 | Kholdebarin R Boetto J Harnish JL | 2008 | Surg Innov2008，15，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员