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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Developing a low-cost milliliter-scale chemostat array for precise control of cellular growth显示文摘 | David Skelding Samuel F M Hart Thejas Vidyasagar Alexander E Pozhitkov Wenying Shou | 2018 | Frontiers of Electrical and Electronic Engineering in China2018，6，2： | 2 |
| 3 | GDF5 SNP rs143383 is as-sociated with lumbar disc disease in northern European women显示文摘 | Williams F Popham M Hart D | 2011 | Arthritis Rheum2011，3，： | 1 |
| 4 | Medical treatment of Rasmussen' s syndrome( chronic encephalitis and epilepsy)显示文摘 | Hart YM Cortez M Andermann F | 1994 | Neuralogy1994，44，6： | 1 |
| 5 | Ankylosing spondylitis andHLA-B27显示文摘 | Brewerton D A Caffrey M Hart F D | 1973 | Lancet1973，1，7809： | 1 |
| 6 | Phosphorus Runoff From Agricultural Land and Direct Fertilizer Effects:A Review 显示文摘 | HART M R QUIN B F NGUYEN M L | 2004 | Jour- nal of Environmental Quality2004，33，6： | 1 |
| 7 | The mode of action of the Bacillus thuringiensis vegetative insecticidal protein Vip3A differs from that of Cry1Ab delta-endotoxin显示文摘 | Lee M K Walters F S Hart H | 2003 | Applied and Environmental Microbiology2003，69，46： | 1 |
| 8 | A long-lasting interferon-gamma response is induced to a single inoculation of antigen-pulsed dendritic cells显示文摘 | Dillon S M Griffon J F Hart D N | 2006 | Immunology2006，103，1： | 1 |
| 9 | GDF5 single-nu- cleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women 显示文摘 | Williams F M Popham M Hart D J | 2011 | Arthritis Rheum2011，63，3： | 1 |
| 10 | GDF5 single nucleotide polymorr phism rs143383 is associated with lumbar disc degeneration inNorthern European women显示文摘 | Williams F M Popham M Hart D J de Schepper E Bierma Zeinstra S Hofman A | 2011 | Arthritis Rheum2011，63，： | 1 |
| 11 | Pharmacokinetics, safety, and efficacy of mycophenolate mofetil in combination with sirolimus or ciclosporin in renal transplant patients显示文摘 | Pescovitz MD Vincenti F Hart M | 2007 | Br J Clin Pharmacol2007，64，6： | 1 |
| 12 | A somatic cell hybrid with a single human chromosome 22 corrects the defect in the CHO mutant (Ade- I )lacking adenylosuccinase activity 显示文摘 | Van Keuren M L Hart I M Kao F T | 1987 | Cytogenet Cell Genet1987，44，： | 1 |
| 13 | Three dimensional ana- lytical simulation of flexible pipe wall structure显示文摘 | McNamara J F Harte A M | 1992 | Journal of Offshore Mechanics and Arctic Engineer- ing1992，114，2： | 1 |
| 14 | A BODIPY-Dcdved Fluorescent Probe for Cellular pH Measurements 显示文摘 | Hart F F Xu Y M Jieng D C eta/ | 2013 | Ana/yffca/ Biochemistry2013，435，2： | 1 |
| 15 | The mediating role of distributive,procedural,and interactional justice on the relationship between downsizing and organizational citizenship behavior显示文摘 | Hart A L Thomson N F Huning T M | 2016 | Journal of Organizational Culture Communications&Conflict2016，20，： | 1 |
| 16 | Strategies for the isolation of cellulolytic fungi for composting of wheat straw显示文摘 | Hart T D De Leij F A A M Kinsey G | 2002 | World Journal of Microbiology & Biotechnology2002，18，5： | 1 |
| 17 | Phosphorus runoff from agricultural land and direct fertilizer effects:a review显示文摘 | HART M R QUIN B F NGUYEN M L | 2004 | Journal of Environmental Quality2004，33，： | 1 |
| 18 | Phosphorus runoff from agricultural land and direct fertilizer effects:A review显示文摘 | Hart M R Quin B F Nguyen M L | 2004 | Environment Quality2004，33，6： | 1 |
| 19 | Development of mental health first aid guidelines for Aboriginal and Tortes Strait Islander people experiencing problems with substance use: a Delphi study显示文摘 | HART L M BOURCHIER S J JORM A F | 2010 | BMC Psychiatry2010，10，： | 1 |
| 20 | Overexpression of a knotted-like homeobox gene of potato alters vegetative develop- ment by decreasing gibberellin accumulation显示文摘 | Rosin F M Hart J K Homer H T | 2003 | Plant Physiology2003，132，： | 1 |
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