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您的检索式：作者名="Haruki Higashino"
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| 1 | Low-intensity walking as mild medication for pressure control in prehypertensive and hypertensive subjects:how far shall we wander?显示文摘Successful prevention and treatment of hypertension depend on the appropriate combination of antihypertensive drug therapy and nondrug lifestyle modi?cation. While most hypertension guidelines recommend moderate- to high-intensity exercise, we decided to explore a mild yet effective type of exercise to add to hypertension management, especially in populations with complications or frailty. After comparing the short-term cardiovascular effects of low-speed walking versus high-speed walking for 3 kilometers (km)(3 km/h versus 6 km/h) in young, healthy volunteers, we delivered low-speed walking (low-intensity walking, 2.5 metabolic equivalents of task, METs) as exercise therapy in 42 prehypertensive and 43 hypertensive subjects. We found that one session of 3 km low-intensity walking exerted a transient pressure-lowering effect as well as a mild negative chronotropic effect on heart rate in both the prehypertensive and hypertensive subjects;these short-term bene?ts on blood pressure and heart rate were accompanied by a brief increase in urine β-endorphin output. Then we prescribed regular low-intensity walking with a target exercise dose (exercise volume) of 500–1000 METs·min/week (50–60 min/day and 5–7 times/week) in hypertensive subjects in addition to their daily activities. Regular low-intensity walking also showed mild but signi?cant blood pressure-lowering and heart rate-reducing effects in 7 hypertensive subjects within two months. It is hypothesized that regular low-intensity exercise of the necessary dose could be taken as a pragmatic and supplementary medication for hypertension management. | Qin Lu Sheng-ming Wang Yi-xiao Liu Hong Chen Rui Zhang Wen-hui Zhang Yuan-yuan Zou Jia-wei Zhou Xin-yi Guo Ying Zhang Teng-Li Huang Yu-hang Liu Si-qi Zhang Kyosuke Yamanishi Hiromichi Yamanishi Hideaki Higashino Haruki Okamura | 2019 | Acta Pharmacologica Sinica2019，40，8： | 2 |
| 2 | Effect of precipitation/re-dissolution processes from the supersaturated solution on the intestinal absorption of poorly water-soluble drugs显示文摘As one of the possible technologies to improve the oral absorption of poorly water-soluble drugs, supersaturable formulation, which enables to dissolve the drug to the higher concentration than their equilibrium solubility, is now attracting the attention (1)This include salt-formation, soliddispersion, co-crystallization or the use of amorphous form.Since supersaturation is a thermodynamically metastable state,supersaturated solution has a high potential to precipitate. Some pharmaceutical excipients. | Haruki Higashino Keiko Minami Makoto Kataoka Shinji Yamashita | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 0 |
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