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| 1 | Distortion of memory Vδ2 γδ T cells contributes to immune dysfunction in chronic HIV infection显示文摘γ δT 房间是在天生的豁免起重要作用对传染疾病的辩护首要。人的免疫不全病毒(HIV ) 感染破坏在 Vδ 之间的平衡; 1 T 房间和 Vδ在 γ 之中的 2 T 房间和原因机能障碍; δT 房间。然而,生物机制和这混乱的临床的后果要求进一步的调查。在这研究,我们执行了显型的全面分析和记忆 γ 的功能; δ在有 HIV 感染的中国个人的队的 T 房间。我们在记忆 Vδ 发现了一个动态变化; 2γ δT 房间,扭曲了向一激活并且严重地区分了受动器记忆显型 T EMRA Vδ 2γ δT 房间,可以说明 Vδ 的机能障碍, 2γ δ在 HIV 疾病的 T 房间。另外,我们发现那 IL-17-producing γ δT 房间显著地与快疾病前进在感染 HIV 的病人被增加并且断然与 HLA 医生 +γ 相关; δT 房间和 CD38 +HLA 医生 +γ δT 房间。这建议表明小径的 IL-17 涉及 γ δT 房间激活和 HIV 致病。我们的调查结果提供新奇卓见进 Vδ 的角色; 2 T 房间在 HIV 致病期间并且代表与这些房间考虑有免疫力的治疗的一个健全基础。 | Zhen Li Yanmei Jiao Yu Hu Lianxian Cui Dexi Chen Hao Wu Jianmin Zhang Wei He | 2015 | Cellular & Molecular Immunology2015，12，5： | 7 |
| 2 | First Report of the Multiresistance Gene cfr in Streptococcus suis显示文摘 | Yang Wang Dexi Li Li Song Yang Liu Tao He Hebing Liu Congming Wu Stefan Schwarz Jianzhong Shen | 2013 | Antimicrobial Agents and Chemotherapy2013，，8： | 1 |
| 3 | Numerical Simulation of Natural Wind Field 显示文摘 | Li Mingshui He Dexi | 1999 | ACTA AERODYNAM1CA SINICA1999，17，1： | 1 |
| 4 | Occurrence Regularity and Control of Thrips on Leek显示文摘[Objective] The paper was to clear the species and occurrence regularity of thrips severely occurred in leek field, and to study the main control methods. [Methods] The species of thrips on leek were identified in Sichuan Province, and the damage symptoms, occurrence regularity and control methods of thrips in leek field were studied. [Result] The morphological characteristic of thrips on leek was Frankliniella occidentalis(Pergande). ITS molecular identification results showed that the amplified fragment was 520 bp, which shared the similarity of 99.81% with the base se-quence of F. occidentalis. F. occidentalis concentrated at the height of 80 cm from the ground; in sunny days, the occurrence frequency of F. occidentalis was relatively high during 15:00 and 17:00; rainwater had obvious lethal effect on F. occidentalis, and the lethal rate was 29.30%. Field trial showed that 20% dinotefuran SG and 40% acetamiprid GR had good control effect against F. occidentalis. The control effect of 20% dinotefuran SG 1 500 times dilution was the best, up to 92.56%. [Conclusion] The results will provide effective technical support for large-scale control of thrips in leek field. | Chen Dexi He Zhongquan Guo Yunjian Huang Tengfei Yi Xueqing Liu Huan Lu Daijuan Liu Fuping | 2018 | Plant Diseases and Pests2018，9，3： | 0 |
| 5 | Watermelon domestication was shaped by stepwise selection and regulation of the metabolome显示文摘Although crop domestication has greatly aided human civilization,the sequential domestication and regulation of most quality traits remain poorly understood.Here,we report the stepwise selection and regulation of major fruit quality traits that occurred during watermelon evolution.The levels of fruit cucurbitacins and flavonoids were negatively selected during speciation,whereas sugar and carotenoid contents were positively selected during domestication.Interestingly,fruit malic acid and citric acid showed the opposite selection trends during the improvement.We identified a novel gene cluster(CGC1,cucurbitacin gene cluster on chromosome 1)containing both regulatory and structural genes involved in cucurbitacin biosynthesis,which revealed a cascade of transcriptional regulation operating mechanisms.In the CGC1,an allele caused a single nucleotide change in Cl ERF1 binding sites(GCC-box)in the promoter of Cl Bh1,which resulted in reduced expression of Cl Bh1 and inhibition of cucurbitacin synthesis in cultivated watermelon.Functional analysis revealed that a rare insertion of 244 amino acids,which arose in C.amarus and became fixed in sweet watermelon,in Cl OSC(oxidosqualene cyclase)was critical for the negative selection of cucurbitacins during watermelon evolution.This research provides an important resource for metabolomics-assisted breeding in watermelon and for exploring metabolic pathway regulation mechanisms. | Pingli Yuan Congping Xu Nan He Xuqiang Lu Xingping Zhang Jianli Shang Hongju Zhu Chengsheng Gong Hanhui Kuang Tang Tang Yong Xu Shuangwu Ma Dexi Sun Weiqin Zhang Muhammad J.Umer Jian Shi Alisdair R.Fernie Wenge Liu Jie Luo | 2023 | Science China(Life Sciences)2023，66，3： | 0 |
| 6 | Deadlock Detection in FPGA Design: A Practical Approach显示文摘Formal verification of VHSIC Hardware Description Language(VHDL) in Field-Programmable Gate Array(FPGA) design has been discussed for many years. In this paper we provide a practical approach to do so. We present a semi-automatic way to verify FPGA VHDL software deadlocks, especially those that reside in automata.A domain is defined to represent the VHDL modules that will be verified; these modules will be transformed into Verilog models and be verified by SMV tools. By analyzing the verification results of SMV, deadlocks can be found;after looking back to the VHDL code, the deadlocking code is located and the problem is solved. VHDL verification is particularly important in safety-critical software. As an example, our solution is applied to a Multifunction Vehicle Bus Controller(MVBC) system for a train. The safety properties were tested well in the development stage, but experienced a breakdown during the long-term software testing stage, which was mainly caused by deadlocks in the VHDL software. In this special case, we managed to locate the VHDL deadlocks and solve the problem by the FPGA deadlock detection approach provided in this paper, which demonstrates that our solution works well. | Dexi Wang Fei He Yangdong Deng Chao Su Ming Gu Jiaguang Sun | 2015 | Tsinghua Science and Technology2015，20，2： | 0 |
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