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| 1 | Nature brings new avenues to the therapy of central nervous system diseases——an overview of possible treatments derived from natural products显示文摘Natural products(NPs), including traditional Chinese medicine(TCM), have been long and widely used in the prevention and treatment of central nervous system(CNS) diseases by virtue of their abundant sources, diverse structures, and novel activities.In this review article, we intend to summarize and discuss the situation or status of the clinical employments or trials of the NPs and their derivatives with CNS activities. NPs that have been extensively studied in preclinical research in recent years are also included. The compounds presented in this review are classified according to their indications and followed by details such as natural sources, possible biological mechanisms, and development status, while a considerable proportion of them are found in TCM. In addition, some drug combinations with synergistic effects are also mentioned. According to their impressive therapeutic effects and novel chemical structures, NPs are not only effective therapeutic remedies in clinic, but also lead compounds for structural modification, which indicate that nature brings new avenues to the therapy of CNS diseases. | Junchi Zhang Yang He Xiangrui Jiang Hualiang Jiang Jingshan Shen | 2019 | Science China(Life Sciences)2019，62，10： | 30 |
| 2 | SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target显示文摘Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.However,the origin of excessive damages caused by SARS-CoV-2 remains largely unknown.Here we show that the SARS-CoV-2 envelope(2-E)protein alone is able to cause acute respiratory distress syndrome(ARDS)-like damages in vitro and in vivo. | Bingqing Xia Xurui Shen Yang He Xiaoyan Pan Feng-Liang Liu Yi Wang Feipu Yang Sui Fang Yan Wu Zilei Duan Xiaoli Zuo Zhuqing Xie Xiangrui Jiang Ling Xu Hao Chi Shuangqu Li Qian Meng Hu Zhou Yubo Zhou Xi Cheng Xiaoming Xin Lin Jin Hai-Lin Zhang Dan-Dan Yu Ming-Hua Li Xiao-Li Feng Jiekai Chen Hualiang Jiang Gengfu Xiao Yong-Tang Zheng Lei-Ke Zhang Jingshan Shen Jia Li Zhaobing Gao | 2021 | Cell Research2021，31，8： | 7 |
| 3 | Microstructure and performance of dissimilar joint QCr0.8/TC4 welded by uncentered electron beam显示文摘The mechanical property of dissimilar metal joint between QCr0.8 and TC4 alloy made with centered electron beam is bad and the highest tensile strength of the joint is only about 82.1 MPa.The bad mechanical property is mainly caused by the asymmetric fusion of the two base metals and the generation of the brittle Ti-Cu intermetallic compounds.The finite element analysis shows that the amount of the melted QCr0.8 copper alloy can be added to reduce the amount of the brittle intermetallic compounds.The bias distance to the copper alloy hc has obvious effect on the tensile strength.When hc=0.8 mm,the tensile strength of the joint can reach 270.5 MPa.The reaction layer near the fusion line on the TC4 side consists of the intermetallic compound and the melted base metal which does not react.The joint fractures at the reaction layer and presents quasi-cleavage or transcrystalline rupture in tensile tests. | LIU Wei,ZHANG Binggang,HE Jingshan and ZHAO Haisheng State Key Laboratory of Advanced Welding Production Technology,Harbin Institute of Technology,Harbin 150001,China | 2007 | Rare Metals2007，26，S1： | 5 |
| 4 | Microstructure characterization of electron beam welded joints of Ti_3Al after post-weld heat treatment显示文摘The effect of post-weld heat treatment on the microstructure characterization of electron beam welded(EBW) joints of Ti3Al-Nb was investigated.The results show that the microstructure of the weld is predominantly metastable,the columnar crystal metastructure of B2 phase.The microstructure morphology of the weld is significantly influenced by the method of the heat treatment.The microstructure of the weld is laminar structure(Widmanstaten structure) consisted of interphase α2 and B2 after post-weld heat treatment of 1000 ℃/2 h.The mechanism of the post-weld heat treatment makes the hardness distribution of joints homogeneous,but makes the whole joint somehow softened. | HE Jingshan,WU Qingsheng,ZHANG Binggang,LIU Wei,and FENG Jicai State Key Laboratory of Advanced Welding Production Technology,Harbin Institute of Technology,Harbin 150001,China | 2007 | Rare Metals2007，26，S1： | 3 |
| 5 | Materials Characterization显示文摘 | Feng Jicai Wu Huiqiang He Jingshan | 2005 | 54(2):992005，54，2： | 1 |
| 6 | Numerical simulation on the shape of liquid surface of TIG full-penetrated weld pool显示文摘Based on the analysis of the three-dimensional liquid surface behavior of TIG penetrated weld pool,the three-dimensional shape models of weld pool with different values of the back fusion zone radius RB were obtained.The effects of arc on the penetrated weld pool were studied by numerical simulation with finite elements analysis software Surface Evolver.The results show that the size and shape of the back weld pool are not affected obviously by the arc,and the top surface of the weld pool is lowered by arc.From pulse background to pulse peak,the increase of the arc voltage(or the arc light intensity) is due to two factors.One is the increase of the current,and the other is the lowering of the top weld pool | HE Jingshan,LIU Wei,ZHANG Binggang,WU Qingsheng,and FENG Jicai State Key Laboratory of Advanced Welding Production Technology,Harbin Institute of Technology,Harbin 150001,China | 2007 | Rare Metals2007，26，S1： | 1 |
| 7 | Microstructure evolution and fracture behaviour for electron beam welding of Ti-6Al-4V显示文摘 | Wu Huiqiang Feng Jicai He Jingshan | 2004 | Bulletin of Materials Science2004，，4： | 1 |
| 8 | Educational Assessment via a Web-Based Intelligent System显示文摘 | Jingshan Huang Lei He Gayle V. Davidson-Shivers | 2011 | 美中教育评论2011，8，5： | 0 |
| 9 | Selective coordination of polyazin sapanisertib with halide vacancy for printable mesoscopicperovskite solar cells显示文摘The mitigation of under-coordinated Pb^(2+)(halide vacancy)defect remains an imperative challenge in the perovskite solar cells,especially printable mesoscopic perovskite solar cells(FP-PsCs).Here we re port a commercial-available polyazin anticancer drug Sapanisertib as coordination passivator of halide vacancies in FP-PSCs,thereby achieving the photoelectric conversion efficiency(PCE)to 18.46%,along with a record certified PCE of 18.27%.In polazin Sapanisertib(Sap),there exists two kinds of nitrogen atoms:in-aromatic ring(in purine and oxazole rings,IAR-Ns)and out-aromatic ring(substituted amino groups,OAR-Ns).Through multiple characterizations,and DFT calculations show that substituted amino groups OAR-Ns hardly get interaction with the halide vacancy due to the distribution of charge density in Sapanisertib.Our work suggests that the selective coordination is of great significance for the design of high-performance passivators for printable mesoscopic perovskite solar cells. | Dun Ma Xiujun He Jingshan He Huanxin Guo Yongzhen Wu Wenjun Wu Weihong Zhu | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
| 10 | Effect of arc force on shape of the welding pool显示文摘Based on the three-dimensional model of TIG weld pool established,the effect of the arc force on liquid surface was investigated.The simulation was carried out with finite elements software Surface Evolver.The influence of the arc force on the weld pool shape was also studied.According to the results,the variation of the weld shape and the parameters with different arc force strength was obtained.Compared with the back weld pool,the top weld pool was influenced more strongly by the arc force.These results provide an effective basis for further study of the TIG weld pool. | LIU Wei,HE Jingshan,ZHANG Binggang,WU Qingsheng,and FENG Jicai State Key Laboratory of Advanced Welding Production Technology,Harbin Institute of Technology,Harbin 150001,China | 2007 | Rare Metals2007，26，S1： | 0 |
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