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| 1 | BATE curve in assessment of clinical utility of predictive biomarkers显示文摘In this paper,for time-to-event data,we propose a new statistical framework for casual inference in evaluating clinical utility of predictive biomarkers and in selecting an optimal treatment for a particular patient.This new casual framework is based on a new concept,called Biomarker Adjusted Treatment Effect (BATE) curve.The BATE curve can be used for assessing clinical utility of a predictive biomarker,for designing a subsequent confirmation trial,and for guiding clinical practice.We then propose semi-parametric methods for estimating the BATE curves of biomarkers and establish asymptotic results of the proposed estimators for the BATE curves.We also conduct extensive simulation studies to evaluate finite-sample properties of the proposed estimation methods.Finally,we illustrate the application of the proposed method in a real-world data set. | ZHOU XiaoHua 1,2,3,& MA YunBei 4,5 1 Northwest HSR&D Center of Excellence,VA Puget Sound Health Care System,Seattle,WA 98198,USA 2 Department of Biostatistics,University of Washington,Seattle,WA 98198,USA 3 Beijing International Center for Mathematical Research,Peking University,Beijing 100871,China 4 Department of Operations Research and Financial Engineering,Princeton University,Princeton,NJ 08540,USA 5 School of Statisitcs,Southwest University of Finance and Economics,Chengdu 611130,China | 2012 | Science China Mathematics2012，55，8： | 2 |
| 2 | Impact of mobile health and medical applications on clinical practice in gastroenterology显示文摘Mobile health apps (MHAs) and medical apps (MAs) are becoming increasinglypopular as digital interventions in a wide range of health-related applications inalmost all sectors of healthcare. The surge in demand for digital medical solutionshas been accelerated by the need for new diagnostic and therapeutic methods inthe current coronavirus disease 2019 pandemic. This also applies to clinicalpractice in gastroenterology, which has, in many respects, undergone a recentdigital transformation with numerous consequences that will impact patients andhealth care professionals in the near future. MHAs and MAs are considered tohave great potential, especially for chronic diseases, as they can support the selfmanagementof patients in many ways. Despite the great potential associated withthe application of MHAs and MAs in gastroenterology and health care in general,there are numerous challenges to be met in the future, including both the ethicaland legal aspects of applying this technology. The aim of this article is to providean overview of the current status of MHA and MA use in the field ofgastroenterology, describe the future perspectives in this field and point out someof the challenges that need to be addressed. | Sven Kernebeck Theresa S Busse Maximilian D Bottcher Jurgen Weitz Jan Ehlers Ulrich Bork Didactics Educational Research in Health | 2020 | World Journal of Gastroenterology2020，26，29： | 2 |
| 3 | Three- Dimensional Helical CT of Intrahepatic Venous Structure: Comparison of Three Rendering Techniques 显示文摘 | Soyer P Health D Bluemake B | 1996 | J Comput Assist Tomogr1996，20，1： | 1 |
| 4 | What can our patients actually use? 显示文摘 | Bernstam E V Shelton D M Walji M Instruments to assess the quality of health information on the World Wide Web | 2005 | International Journal of Medical Informatics2005，74，1： | 1 |
| 5 | A Patho Physeological study of 10 caes of hypoxic cor pulmonale显示文摘 | Wilkinoson M Langhorm CA Health D | 1998 | QJ Med1998，66，： | 1 |
| 6 | Performance and heterosis in fanned and wild chinook salmon ( Oncorhynchus tstaurytscha) hybrid and purebred crosses 显示文摘 | Bryden C A Heath J W Health D D | 2004 | Aquaculture2004，235，： | 1 |
| 7 | Three-dimensional helical CT of inlxahepatie venous structures: comparison of three rendering technique显示文摘 | Soyer P health D Bluemke DA | 1997 | J Comput Assisl Tomogr1997，20，： | 1 |
| 8 | Psychiatric disorders associated with intimate partner violence and sexual violence in Thai women:Aresult from the Thai National Mental Health Survey显示文摘Background Intimate partner violence(IPV) and sexual violence(SV) occur commonly and are a violation of basic human rights. There are limited studies to date that examine the impact of IPV, SV and mental health outcomes in Thailand.Aims The objective of the present study was to estimate the prevalence of intimate partner physical violence and IPV in Thai women and the association between these forms of violence and psychiatric disorders.Methods The present study used data from a national cross-sectional, population-based, household design survey. This study analysed data from 3009 female respondents above the age of 18 who were interviewed in person using the World Mental Health-Composite International Diagnostic Interview V.3.0(WMH-CIDI 3.0). We estimated the lifetime and the 12-month period prevalence of IPV and SV, the lifetime and the past 12-month period correlation of IPV/SV with psychiatric disorders and the OR for psychiatric disorders associated with these types of violence.Results There was only 5.2 % of the weighted sample that reported experiencing some form of violence, including reported rates of intimate partner physical violence of 3.5% and IPV of 2.0%. Women who had experienced IPV have a lifetime prevalence for common psychiatric disorders of 28.9%, for suicidal behaviours of 12.2% and for substance use disorders of 8.8%. Women who had experienced SV have a lifetime diagnoses for common psychiatric disorders of 21.4%, for suicidal behaviours of 16.5% and for substance use disorders of 19.4%. There was a statistically significant association between IPV/SV and being diagnosed with a psychiatric disorder during the past year and also during one's lifetime.Conclusion The association between IPV/SV and psychiatric disorders is significant; therefore, performing a formal assessment for a history of violence in psychiatric patients is often beneficial in refining the diagnosis and treatment. | Benjaporn Panyayong Nopporn Tantirangsee Rudy R D Bogoian the Thai National Mental Health Survey Team 2013 | 2018 | General Psychiatry2018，31，5： | 1 |
| 9 | Emergency medicine the critical role of emergency departments in US public health显示文摘 | HIRSHON J M MORRIS and the health of the public: D M | 2006 | Emerg Med Clin North Am2006，24，4： | 1 |
| 10 | Bond pricing and the term structure of interest rates: a new methodology for contingent claims valuation显示文摘 | Health D Jarrow R Morton A | 1992 | Econometrica1992，60，1： | 1 |
| 11 | Cardiac benefits of fish consumption may depend onthe type of fish meal consumed: the Cardiovascular Health Study显示文摘 | Mozaffarian D Lemaitre R N Kuller L H Burke G L Tracy R P Siscovick D S Cardiovascular Health Stud- y | 2003 | Circulation2003，107，： | 1 |
| 12 | Coherent measures of risk显示文摘 | Artzner P Delbaen F Eber J M Health D | 1999 | Mathematical Finance1999，9，： | 1 |
| 13 | The pathology of hypertension pulmonary vascular disease : a description of six grades of structural changes in the pulmonary arteries with special reference to congenital cardiac septal defects 显示文摘 | Health D Edwards JE | 1998 | Circulation1998，18，： | 1 |
| 14 | Cleavge of nuclear DNA oligonuclesomal fragments during cell death induced by fungal infection or by abiotic treatments 显示文摘 | HEALTH M C | 1996 | Plant Cell1996，8，： | 1 |
| 15 | From single user to multiuser communications: Shifting the MIMO paradigm 显示文摘 | Gesbert D Kountouris M Health Jr R W | 2007 | IEEE Signal Processing Magazine2007，，10： | 1 |
| 16 | The constancy of the mean net assimilation rate and its ecological importance 显示文摘 | HEALTH D V GREGORY F G | 1938 | Ann Botany1938，2，： | 1 |
| 17 | The Lung Health Study:airway responsiveness to inhaled methacholine in smokers with mild to moderate airflow limitation显示文摘 | Tashkin D P Altose M D Bleecker ER and the Lung Health Research Group | 1992 | Am Rew Respir Dis1992，145，： | 1 |
| 18 | Building capacity for heart health promotion: resuits of a 5 - year experience in Nova Scotia, Canada 显示文摘 | MacLean D Farquharson J Health S | 2003 | American Journal of Health Promotion2003，17，： | 1 |
| 19 | A robust visual method for assessing the relative performance of edge-detection algorithms显示文摘 | Health M D Sarkar S | 1997 | IEEE Transactions on Pattern Analysis and Machine Intelligence1997，19，12： | 1 |
| 20 | Three-dimensional CT:real-time interactive volume rendering显示文摘 | Health D G Bliss D F | 1996 | AJR Am J Roentgenol1996，167，3： | 1 |
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