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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | 2012 (9859)2012，，9859： | 3 |
| 3 | Glucocorticoids and prostate cancer treatment: friend or foe?显示文摘Glucocorticoids 在前列腺癌症的治疗被使用了减缓疾病前进,改进疼痛控制并且抵消 chemo- 和神经质的治疗的副作用。然而,他们可以也有潜力经由变异的雄激素受体或 glucocorticoid 受体(GR ) 驾驶前列腺癌症生长。在这评论,我们在前列腺癌症的治疗检验 glucocorticoids 的历史、当代的使用,考察他们可以由禁止或开车前列腺癌症生长的潜在的机制,并且描述定义他们对前列腺癌症的生物学的贡献的潜在的工具。 | Bruce Montgomery Heather H Cheng James Drechsler Elahe A Mostaghel | 2014 | Asian Journal of Andrology2014，16，3： | 2 |
| 4 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet2012，，9859： | 2 |
| 5 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet . 2012 (9859)2012，，9859： | 1 |
| 6 | Pharmacodynamic and pharmacokinetic study of oral curcuma extract in patients with colorectal cancer显示文摘 | RICKY A S HEATHER R M KIRSTI A H | 2001 | Clin Cancer Res2001，7，7： | 1 |
| 7 | Nonrandom genotypic associations in a legume-Bradyrhizobium mutualism 显示文摘 | Jill M S Heather H W Matthew A P | 1996 | Evolution1996，50，1： | 1 |
| 8 | High efficiency production of germ-line transgenic Japanese medaka(Oryzias latipes) by electroporation with direct current-shifted radio frequency pulses显示文摘 | Heather A H Stephanie L P William M M | 2003 | Transgenic Res2003，12，： | 1 |
| 9 | Statistical modeling of interlocus interactions in a complex disease显示文摘 | HEATHER J C JOHN A T NATASHA J H | 2001 | Genetics2001，158，： | 1 |
| 10 | Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer 显示文摘 | Ricky A S Heather R M Kirsti A H | 2001 | Clin Cancer Res2001，7，7： | 1 |
| 11 | Venous thromboem￣bolism prevention in gynecologic cancer surgery:A systematic review显示文摘 | Heather E E M Elizabeth A P Ellen M H | 2007 | Gynecologic Oncology2007，105，3： | 1 |
| 12 | Successful parallel development and integration of a plasmid-based biologic, container/closure system and electrokinetic delivery device 显示文摘 | Henry H Heather A Amir K | 2006 | Vaccine2006，24，： | 1 |
| 13 | Measurement of brewing yeast viability and vitality: A review of methods 显示文摘 | HEATHER H MARGARITIS A STEWART R J et al | 2000 | Tech Q Master Brew Assoc Am2000，37，4： | 1 |
| 14 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet2012，，9859： | 1 |
| 15 | Nonrandom genotypic associations in a legume-Bradyrhizobium mutualism显示文摘 | Jill M S Heather H W Matthew A P | 1996 | Evolution1996，50，1： | 1 |
| 16 | Rapid detection, identification, and enumeration of Pseudomonas aeruginosa in bottled water using peptide nucleic acid probes显示文摘 | STENDER H BROOMER A OLIVEIRA K Heather Perry-O'Keefe | 2000 | Journal of Microbiological Methods2000，42，： | 1 |
| 17 | Pharmacodynamie aud pharmacokinetic study of oral eureuma extract in patients with colorectal cancer 显示文摘 | Ricky A S Heather R M Kirsti A H | 2001 | Clinical Cancer Research2001，7，7： | 1 |
| 18 | Determinmion of rat oral bioavailahility of soy-derived phytoeslrogens using an automated on-col- umn extraction predure and electrospray tandem mass spectrometry 显示文摘 | LARRY M M ANI B S HEATHER A H | | J Chromatogr B0，796，： | 1 |
| 19 | Zygomycosis (mucormycosis): emerging clinical importance and new treatments显示文摘 | Richard N Greenberg Lauren J Scott Heather H Vaughn Julie A Ribes | 2004 | Current Opinion in Infectious Diseases2004，，： | 1 |
| 20 | Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer显示文摘 | Ricky A S Heather R M Kirsti A H | 2001 | Clin Cancer Rcs2001，7，7： | 1 |
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