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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Randomised trial of flush saphenofemoral ligation for primary great saphenous varicose veins 显示文摘 | WINTERBORN R J FOY C HEATHER B P | 2008 | Eur J Vasc Endovasc Surg2008，36，4： | 1 |
| 3 | Oxidative stress markers are associated with persistent atrial fibrillation显示文摘 | Robert B Heather L Irfan S | 2007 | Clin Chem2007，53，9： | 1 |
| 4 | Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo:role of P-selectin显示文摘 | Vandana S D Wolfgang B Heather A M | 2005 | Blood2005，106，7： | 1 |
| 5 | Acousto-Optic Tunable Flters: Fundamentals and Applications as Applied to Chemical Analysis Techniques显示文摘 | Ling B Glenn I D Heather M M | 2004 | Progress in Quantum Electronics2004，，28： | 1 |
| 6 | The pros and cons of phytoestro- gens 显示文摘 | HEATHER B JEFFERSON W | 2010 | Front Neuroendocrinol2010，31，4： | 1 |
| 7 | Studies on the microbial populations of the rhizosphere of big sagebrush (Artemisia tridentata)显示文摘 | Antony J B Janice L S Heather M K | 2004 | Journal Indian Microbiology and Biotechnology2004，31，6： | 1 |
| 8 | Sulfuryl Fluoride: the postharvest fumigant of the future? 显示文摘 | Heather G Schneider B | 2000 | Methyl Bromide Alternatives2000，6，4： | 1 |
| 9 | Induced systemic resistance and the role of binucleate Rhizoctonia and Trichoderma hamatum 382 in biocontrol of Botrytis blight in geranium 显示文摘 | HEATHER A OLSON D MICHAEL B | 2007 | Biological Control2007，42，2： | 1 |
| 10 | The immunomodulatory agents lenalidomide and thalidomide for treatment of the myelodysplastic syndromes:A clinical practice guideline显示文摘 | Heather AL Rena B April S | 2013 | Critical Reviews in Oncology/Hematology2013，85，2： | 1 |
| 11 | Induced systemic resistance and the role of binucleate Rhizoctonia and Trichoderma hamatum 382 in biocontrol ofBotrytis blight in geranium显示文摘 | Heather A Olson D Michael B | 2007 | Biological Control2007，42，2： | 1 |
| 12 | Photocatalytic degradation of 17-β-oestradiol on immobilised TiO2 显示文摘 | Heather MC Brian RE J Anthony B | 2000 | Applied Catalysis B : Environmental2000，24，1： | 1 |
| 13 | Influence of Vehicle, Distant Topical Delivery, and Biotransformation on the Chemoreceptive Activity of Apigenin, a Plant Flavonoid, in Mouse Skin 显示文摘 | Boyong Li Heather Pinch Diane F B | 1996 | Pharm Res1996，13，10： | 1 |
| 14 | Selenium deficiency increases the pathology of an influenza virus infection显示文摘 | Melinda A B Heather K N Peter V D | 2001 | FASEB2001，10，： | 1 |
| 15 | Determination of carbendazim in blue berries by reversed phase high 2 perfomance liquid chromatography显示文摘 | Rodney J B Heather L H Jasotha K | 1991 | Journal of Chromatography1991，，587： | 1 |
| 16 | Repetitive task practice:a critical review of Constraint-Induced Movement Therapy in sroke显示文摘 | Wolf SL Sarah B Heather B | 2002 | Neurologist2002，8，6： | 1 |
| 17 | Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol - and obesity - induced fatty liver diseases 显示文摘 | Mantena Sudheer K King Adrienne L Andringa Kelly K Ec- cleston Heather B Bailey Shannon M | 2008 | Free radical biology & medi- cine2008，44，7： | 1 |
| 18 | 母乳喂养史和子宫内膜异位症发生的风险:前瞻性队列研究显示文摘目的研究经产妇母乳喂养、纯母乳喂养、产后闭经时间与子宫内膜异位症发病率的关系。设计前瞻胜队列研究。 | Leslie V Farland A Heather Eliassen Rulla M Tamimi Donna Spiegelman Karin B Michels Stacey A Missmer 龚丽云 王淑珍 | 2018 | 英国医学杂志中文版2018，21，3： | 1 |
| 19 | Biosensor system for continuous monitoring of organophosphate aerosols 显示文摘 | Heather R L Roby G Mike H B | 2007 | Biosensors and Bioelectronics2007，23，： | 1 |
| 20 | Myostatin knockout in mice increases myogenesis and decreases adipogenesis 显示文摘 | Ji L Heather B | 2002 | Bio Biop Rese Comm2002，292，3： | 1 |
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