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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Risk factors for liver disease among adults of Mexican descent in the United States and Mexico显示文摘AIM To compare the prevalence of chronic liver disease(CLD) risk factors in a representative sample of MexicanAmericans born in the United States(US) or Mexico, to a sample of adults in Mexico.METHODS Data for Mexican-Americans in the US were obtained from the 1999-2014 National Health and Nutrition Examination Survey(NHANES), which includes persons of Mexican origin living in the US(n = 4274). The NHANES sample was restricted to Mexican-American participants who were 20 years and older, born in the US or Mexico, not pregnant or breastfeeding, and with medical insurance.The data in Mexico were obtained from the 2004-2013 Health Worker Cohort Study in Cuernavaca, Mexico(n =9485). The following known risk factors for liver disease/cancer were evaluated: elevated aminotransferase levels(elevated alanine aminotransferase was defined as > 40 IU/L for males and females; elevated aspartate aminotransferase was defined as > 40 IU/L for males and females), infection with hepatitis B or hepatitis C,metabolic syndrome, high total cholesterol, diabetes,obesity, abdominal obesity, and heavy alcohol use. The main independent variables for this study classified individuals by country of residence(i.e., Mexico vs the US) and place of birth(i.e., US-born vs Mexico-born).Regression analyses were used to investigate CLD risk factors.RESULTS After adjusting for socio-demographic characteristics,Mexican-American males were more likely to be obese,diabetic, heavy/binge drinkers or have abdominal obesity than males in Mexico. The adjusted multivariate results for females also indicate that Mexican-American females were significantly more likely to be obese, diabetic, be heavy/binge drinkers or have abdominal obesity than Mexican females. The prevalence ratios and prevalence differences mirror the multivariate analysis findings for the aforementioned risk factors, showing a greater risk among US-born as compared to Mexico-born MexicanAmericans. CONCLUSION In this study, Mexican-Americans in the US had more risk factors for CLD than their counterparts in Mexico.These findings can be used to design and implement more effective health promotion policies and programs to address the specific factors that put Mexicans at higher risk of developing CLD in both countries. | Yvonne N Flores Zuo-Feng Zhang Roshan Bastani Mei Leng Catherine M Crespi Paula Ramírez-Palacios Heather Stevens Jorge Salmerón | 2018 | World Journal of Gastroenterology2018，24，37： | 1 |
| 3 | Determination of olanzapine in a Postmortem case显示文摘 | Amanda J J Krista M S Heather N R | 1998 | Journal of Analytical Toxicology1998，22，7： | 1 |
| 4 | Comparing high and low residential density: life cycle analysis of energy use and greenhnuse gas emissions 显示文摘 | Jonathan N Heather L M | 2006 | Journey of Urban Planning and Development2006，，3： | 1 |
| 5 | CD47 deficiency protects mice from diet-induced obesity and improves whole body glucose tolerance and insulin sensitivity显示文摘 | Hasiyeti M Heather N Qi Z | 2015 | Sci Rep2015，5，3： | 1 |
| 6 | On the existence of FNs, a theoretical and experimental study显示文摘 | Heather M N Mark S G Karl C | 2003 | Journal of the Physical Chemistry A2003，107，34： | 1 |
| 7 | Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity 显示文摘 | Heather M Stefan N Mai HS | 1992 | Nature1992，360，2431： | 1 |
| 8 | Factorswhich motivate cancer doctors to involve their patients inreaching treatment decisions 显示文摘 | Heather L Shepherd P N Butow M H N | 2011 | Patient Educ Couns2011，84，5： | 1 |
| 9 | Hypoxia inducible factor1alpha is a positive factor in solid tumor growth显示文摘 | Heather E R Michelle P Wayne M N | 2000 | Cancer Res2000，60，15： | 1 |
| 10 | Recent advances in understanding the molecular basis of group B Streptococcus virulence 显示文摘 | Heather C M Kelly S D Victor N | 2009 | Expert Rev Mol Med2009，，3： | 1 |
| 11 | Hypoxia Inducible Factor Lalpha is a Positive Factor in Solid Tumor Growth 显示文摘 | Heather E R Michelle P Wayne M N | 2000 | Cancer Res2000，，60： | 1 |
| 12 | Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity显示文摘 | Heather M Stefan N Mai H S et a1 | 1992 | Nature1992，360，2431： | 1 |
| 13 | DNA Deamination Mediates Innate Immunity to Retroviral Infection显示文摘 | Reuben S Harris Kate N Bishop Ann M Sheehy Heather M Craig Svend K Petersen-Mahrt Ian N Watt Michael S Neuberger Michael H Malim | 2003 | Cell2003，，6： | 1 |
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