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| 1 | Review of the current targeted therapies for non-small-cell lung cancer显示文摘The last decade has witnessed the development of oncogene-directed targeted therapies that have significantly changed the treatment of non-small-cell lung cancer(NSCLC). In this paper we review the data demonstrating efficacy of gefitinib, erlotinib, and afatinib, which target the epidermal growth factor receptor(EGFR), and crizotinib which targets anaplastic lymphoma kinase(ALK). We discuss the challenge of acquired resistance to these small-molecular tyrosine kinase inhibitors and review promising agents which may overcome resistance, including the EGFR T790 Mtargeted agents CO-1686 and AZD9291, and the ALKtargeted agents ceritinib(LDK378), AP26113, alectinib(CH/RO5424802), and others. Emerging therapies directed against other driver oncogenes in NSCLC including ROS1, HER2, and BRAF are covered as well. The identification of specific molecular targets in a significant fraction of NSCLC has led to the personalized deployment of many effective targeted therapies, with more to come. | Kim-Son H Nguyen Joel W Neal Heather Wakelee | 2014 | World Journal of Clinical Oncology2014，5，4： | 13 |
| 2 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | The Lancet2010，，9716： | 2 |
| 3 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | The Lancet2010，，9716： | 2 |
| 4 | Development of a platform tech-nology to generate long-acting protein therapeutics显示文摘 | Heather P Alice T Ian W | 2012 | EndocriAbstr2012，289，2： | 1 |
| 5 | Constitutive expression of a phenylalanine ammonia-lyase gene from Stylosanthes humilis in transgenic tobacco leads to enhanced disease resistance but impaired plant growth显示文摘 | Heather M W Kemal K Neena M | 2002 | Physiological and Molecular Plant Pathology2002，60，6： | 1 |
| 6 | The pros and cons of phytoestro- gens 显示文摘 | HEATHER B JEFFERSON W | 2010 | Front Neuroendocrinol2010，31，4： | 1 |
| 7 | Impact of health literacy on health outcomes in ambulatory care patients:a systematic review显示文摘 | Darcie L Julie W Heather A | 2008 | The Annals of Pharmacotherapy2008，42，9： | 1 |
| 8 | School-based sex education policies and indicators of sexual health among young people: a comparison of the Netherlands,France,Australia and the United States 显示文摘 | Heather W | 2005 | Sex Education2005，5，2： | 1 |
| 9 | Room temperature ionic liquids as novel media for 'clean' liquid-liquid extraction显示文摘 | Jonathan G H Heather D W Richard P S | 1998 | ChemicalCommunications1998，，16： | 1 |
| 10 | Influence of HLA gene polymorphisms on susceptibility and outcome post infection with the SARS-CoV virus显示文摘Dear Editor,Severe Acute Respiratory Syndrome(SARS)has beendescribed as the first pandemic of the 21st century andbetween November 2002 and July 2003,over 8000 peo-ple were infected with the SARS-associated coronavirus(SARS-CoV).Polymorphisms in the human leukocyteantigen(HLA)system have been shown to influencesusceptibility to SARS-CoV but here we were unable | Fang Fang Yuan Zlatibor Velickovic Lesley J Ashton Wayne B Dyer Andrew F Geczy Heather Dunckley Garry W Lynch John S Sullivan | 2014 | Virologica Sinica2014，29，2： | 1 |
| 11 | Room temperature ionic liquids as novel media for 'clean' liquidliquid extraction 显示文摘 | Jonathan G H Heather D W Richard P S | 1998 | Chemical Communications1998，，16： | 1 |
| 12 | Supply chain information sharing in a vendor managed inventory partnership显示文摘 | Andres A Heather N Matthew W | 2004 | Joumal of Business Logistics2004，25，1： | 1 |
| 13 | Bioprotective alkaloids of grass-fungal endophytes symbiosis显示文摘 | Powell P B Heather H W Christopher L S | 1997 | Plant Physiol1997，114，1： | 1 |
| 14 | Nonrandom genotypic associations in a legume-Bradyrhizobium mutualism 显示文摘 | Jill M S Heather H W Matthew A P | 1996 | Evolution1996，50，1： | 1 |
| 15 | Synthesis and Applications of a New Class of Phosphorus Donor Ligands for Asymmetric Catalysis显示文摘 | HEATHER T DONALD S COLIN E MARTIN W | 1997 | Chem commun1997，，： | 1 |
| 16 | Antagonism by three species of Cladosporium to three races of Melampsora larici-populina Kleb显示文摘 | Sharma J K Heather W A | 1981 | Aust For Res1981，11，： | 1 |
| 17 | Post-penetration antagonism by Cladosporium tenuissimum to uredinial induction by Melampsora laricipopulina显示文摘 | Sharma J K Heather W A | 1983 | Trans Br Mycol Soc1983，80，： | 1 |
| 18 | Exploiting the attributes of regional ecosystems for landscape design: The role of ecological restoration in ecological engineering显示文摘 | Mark T S Heather C V Steve W | 2007 | Ecological Engineering2007，30，3： | 1 |
| 19 | Antagonism by three species of Cla- dosporium to three races of Melampsora larici-populina Kleb显示文摘 | Sharma J K Heather W A | 1981 | Aust For Res1981，11，： | 1 |
| 20 | The Efficacy of Apiguard Against Varroa and Tracheal Mite and its Effect on Honey Production显示文摘 | HEATHER R MATTILA GARD W DTIS (Canada) | 2000 | American honey journal2000，，12： | 1 |
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