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127篇 您的检索式：作者名="Hecker J"

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	题名	作者	年代	出处	被引量
1	Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound显示文摘AIM:To evaluate whether contrast enhanced ultrasound(CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer.METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal cancer underwent CEUS before treatment(CEUS date 1) and before the second(CEUS date 2) and fourth(CEUS date 3) cycle of bevacizumab based chemotherapy.Three parameters [PEAK,Time to peak(TTP) and RISE RATE]were correlated with radiological response.RESULTS:For neoadjuvant purpose a reduction of tumour mass was required to assume clinical response.Based on these response criteria there was a significant(P < 0.001) correlation in TTP between metastases of responders(9.08 s) and non-responders(14.76 s) archived on CEUS date 1.By calculating a standardized quotient(metastases divided by normal liver tissue) we were able to define a cut off,predicting response with a sensitivity of 92.3 % and a specificity of 100 %.To reflect a palliative intention only those patients with progressive disease were classified as non-responders.In this stetting TTP was also significantly(P < 0.01) different between responders and non-responders.In contrast,Peak and Rise rate did not show any significant difference between responder and non-responder.CONCLUSION:CEUS might serve as a surrogate marker to predict treatment response in patients with metastasized colorectal cancer who receive antiangiogenic therapy.	Ramin Schirin-Sokhan Ron Winograd Christoph Roderburg Jhenee Bubenzer Nicole Cabral do ó Dorothee Guggenberger Hartmut Hecker Christian Trautwein Jens J W Tischendorf	2012	World Journal of Gastroenterology2012，18，6：	16
2	A 24-week,randomized double-blind study of donepezil in moderate to severe Alzheimer's disesse显示文摘	Feldman H Gauthier S Hecker J	2001	Neurology2001，57，：	1
3	Bronchial collapse during bronchoalveolar lavage in horses is an indicator of lung inflammation显示文摘	Koblinger K Hecker K Nicol J	2014	Equine Vet J2014，46，1：	1
4	Irritant phor- bol derivatives from four Jatropha species 显示文摘	ADOLF W OPFERKUCH H J HECKER E	1984	Phytochem- istry1984，23，1：	1
5	The extracellular proteome of Bacillus licheniformis grown in different media and under different nutrient starvation conditions 显示文摘	Voigt B Dr Schweder T Sibbald MJJB Albrecht D Ehrenreich A Bernhardt J Feesche J Maurer K-H Gottschalk G van Dijl JM Hecker M	2006	Proteomics2006，6，：	1
6	The effects of donepezil in Alzheimer's disease-results from a multinational trial显示文摘	Burns A Rossor M Hecker J Gauthier S Petit H M(o)11er H J Rogers SL Friedhoff LT		0，，03：	1
7	Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients显示文摘	Donskey C J Chowdhry TK Hecker MT	2008	New England Journal of Medicine2008，343，26：	1
8	Acetylcholine and chronic vasculopathy in rat renal allografts 显示文摘	Wilczynska J Pfeil U Zakrzewicz A Dietrich H Korner C Hecker A	2011	Transplantation2011，91，：	1
9	Grinding Force and Power Modeling Based on Chip Thickness Analysis 显示文摘	HECKER R L LIANG S Y WU X J	2007	International Journal of Advanced Manufacturing Technology2007，33，5：	1
10	Pro- drug of cephalosporin RWJ-333441 (MC-04546) with improved aqueous solubility 显示文摘	HECKER S J CALKINS T PRICE M E	2003	Antimicrob Agents Chemother2003，47，6：	1
11	Specific binding of HIV-1 envelope protein gp120 to the structural membrane proteins ezrin and moesin 显示文摘	Hecker C Weise J Schneider-Schaulies HC	1997	Virus Res1997，49，：	1
12	Real-time PCR ar- ray to study effects of chemicals on the Hypothalamic- Pituitary-Gonadal axis of the Japanese medaka 显示文摘	Zhang X Hecker M Park J W	2008	A- quatic Toxicology2008，88，3：	1
13	Epstein Barr virus specific T - cells generated from unstable human atherosclerotic lesions: Implications for plaque inflammation 显示文摘	de Boer U J Teeling P ldu MM Hecker AE van der Wal AC	2006	Atherosclerosis2006，184，2：	1
14	Inclusion-Exclusion of Positive and Negative Past Selves: Mood Congruence as Information显示文摘	Gebauer J E Broemer P Haddock G Hecker U V	2008	Journal of Personality and Social Psychology2008，95，2：	1
15	Effect of donepezil on behavioral symptoms in patients with moderate to severe Alzheimers disease 显示文摘	Gauthier S Feldman H Hecker J	2002	Int Psychogeriatr2002，14，4：	1
16	Salt stress adaptation of Bacillus subtilis: a physiological proteomics approach显示文摘	HOPER D BERNHARDT J HECKER M	2006	Proteomics2006，6，5：	1
17	Global analysis of the general stress response of Bacillus subtilis显示文摘	PETERSOHN A BRIGULLA M HAAS S HOHEISEL J D VOLKER U HECKER M	2001	Journal of Bacteriology2001，183，19：	1
18	Application of machine learning to cognitive radio networks 显示文摘	CLANCY C HECKER J	2007	IEEE Wireless Communications2007，14，4：	1
19	Modeling and vibration mode analysis of a ball screw drive显示文摘	Vicente Diego A Hecker Rogelio L Villegas Fernando J	2012	International Journal of Advanced Manufacturing Technology2012，58，14：	1
20	Geographic Infor- mation System-based Screening for TB, HIV, and Syphilis (GIS-THIS) : A Cross-Sectional Study显示文摘	Goswami N D Hecker E J Vickery C etal	2012	PLoS One2012，7，46：	1

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