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1篇 您的检索式：作者名="Hector Sandoval"

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		题名	作者	年代	出处	被引量
	1	Dynamin Regulates Autophagy by Modulating Lysosomal Function显示文摘Autophagy is a central lysosomal degradation pathway required for maintaining cellular homeostasis and its dysfunction is associated with numerous human diseases. To identify players in autophagy, we tested w1200 chemically induced mutations on the X chromosome in Drosophila fat body clones and discovered that shibire(shi) plays an essential role in starvation-induced autophagy. shi encodes a dynamin protein required for fission of clathrin-coated vesicles from the plasma membrane during endocytosis. We showed that Shi is dispensable for autophagy initiation and autophagosomeelysosome fusion, but required for lysosomal/autolysosomal acidification. We also showed that other endocytic core machinery components like clathrin and AP2 play similar but not identical roles in regulating autophagy and lysosomal function as dynamin. Previous studies suggested that dynamin directly regulates autophagosome formation and autophagic lysosome reformation(ALR) through its excision activity. Here, we provide evidence that dynamin also regulates autophagy indirectly by regulating lysosomal function.	Xuefei Fang Jia Zhou Wei Liu Xiuying Duan Upasana Gala Hector Sandoval Manish Jaiswal Chao Tong	2016	Journal of Genetics and Genomics2016，43，2：	0

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