|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 腹股沟疝复发的时间分析显示文摘目的假设不同术式疝修补术术后复发的发病过程是不同的,那么疝复发的时间也是不同的。该研究的目的是分析影响初次手术到复发后再次手术时间间隔的危险因素。方法研究数据来自瑞典疝登记注册系统。将5年随访期间的每一年的资料作为亚组分列,后合为大组。对于每个危险因素以再次手术为研究终点,运用Cox回归分析复发时间与危险因素之间的关系。结果共分析了142578例,其中7.7%是女性,年龄平均59岁。5年总体复发率为4.3%。多因素分析显示复发疝修补后再次复发的时间较早(P<0.05);第一次手术后如果发生并发症,则发生复发也较早(P<0.05);缝合修补或腹腔镜修补后的复发要早于开放式补片修补者(P<0.05)。通过单因素分析提示,所有缝合修补的早期复发的危险要高于所有补片修补早期复发的危险(P<0.05)。结论不同术式疝修补术后复发的发病过程是不同的。腹腔镜修补、传统疝修补术(不应用补片)和复发疝修补术后早期复发率高可能是由于手术技术失误率较高。 | Magnusson N Nordin P Hedberg M Gunnarsson U Sandblom G | 2011 | 中国实用外科杂志2011，31，4： | 20 |
| 2 | Modulating effects of acyl-CoA synthetase 5-derived mitochondrial Wnt2B palmitoylation on intestinal Wnt activity显示文摘AIM:To investigate the role of acyl-CoA synthetase 5(ACSL5)activity in Wnt signaling in intestinal surface epithelia.METHODS:Several cell lines were used to investigate the ACSL5-dependent expression and synthesis of Wnt2B,a mitochondrially expressed protein of the Wnt signaling family.Wnt activity was functionally assessed with a luciferase reporter assay.ACSL5-related biochemical Wnt2B modifications were investigatedwith a modified acyl-exchange assay.The findings from the cell culture models were verified using an Apcmin/+mouse model as well as normal and neoplastic diseased human intestinal tissues.RESULTS:In the presence of ACSL5,Wnt2B was unable to translocate into the nucleus and was enriched in mitochondria,which was paralleled by a significant decrease in Wnt activity.ACSL5-dependent S-palmitoylation of Wnt2B was identified as a molecular reason for mitochondrial Wnt2B accumulation.In cell culture systems,a strong relation of ACSL5 expression,Wnt2B palmitoylation,and degree of malignancy were found.Using normal mucosa,the association of ACSL5 and Wnt2B was seen,but in intestinal neoplasias the mechanism was only rudimentarily observed.CONCLUSION:ACSL5 mediates antiproliferative activities via Wnt2B palmitoylation with diminished Wnt activity.The molecular pathway is probably relevant for intestinal homeostasis,overwhelmed by other pathways in carcinogenesis. | Christina Klaus Ursula Schneider Christian Hedberg Anke K Schütz Jürgen Bernhagen Herbert Waldmann Nikolaus Gassler Elke Kaemmerer | 2014 | World Journal of Gastroenterology2014，20，40： | 4 |
| 3 | 学习设计的处方显示文摘本文主要描述了一种研究活动,此项活动由参与澳洲大学教育委员会“AUTC”资助项目的研究者负责的。AUTC资助的项目为信息和传播技术及其在弹性学习中的作用。此项目旨在研究和开发通用型学习框架,以便为高等教育提供技术增强型高效能学习经验。鉴于此,研究者一直致力于寻求通用型学习设计的处方,来促进建构知识解决问题。本文总结了所做的各项研究工作,并说明了研究过程中开发的通用学习框架。 | Ron Oliver Barry Harper John Hedberg Sandra Wills Shiriey Agostinho 吴文胜 盛群力 | 2007 | 远程教育杂志2007，25，2： | 3 |
| 4 | Relationship of methane generation to undercompacted shales,shales diapers and mud volcanics显示文摘 | | 1974 | AAPG Bull1974，58，4： | 1 |
| 5 | Decreased phosphorylation of four 20-kDa proteins precedes staurosporine-induced disruption of the actin/myosin cytoskeleton in rat astrocytes 显示文摘 | Mobley PL Hedberg K Bonin L | 1994 | Exp Cell Res1994，214，1： | 1 |
| 6 | Effect of varied release kinetics of the osteogenic thrombin peptide TP508 from biodegradable, polymeric scaffolds on bone formation in vivo显示文摘 | HEDBERG E L KROESE DEUTMAN H C SHIH C K | 2005 | J Biomed Mater Res A2005，72，4： | 1 |
| 7 | Surface -protein interactions on different stainless steel grades - effects of protein adsorption, surface changes and metal release 显示文摘 | Hedberg Y Wang X Hedberg J | 2013 | Journal of Materials Sci- ence - materials in Medicine''2013，24，： | 1 |
| 8 | Perinatal risk factors for atopic disease in conscripts显示文摘 | Braback L Hedberg A | 1998 | Clin Exp Allergy1998，28，8： | 1 |
| 9 | Learning object design considerations forsmall-screen handheld devices 显示文摘 | Churchill D Hedberg J | 2008 | Computers & Education2008，50，3： | 1 |
| 10 | Pitfalls of immunogold labeling; analysis by light microscopy,transmission electron microscopy,and photoelectron microscopy显示文摘 | Birrell G B Hedberg K K Griffith P H | 1987 | Journal of Histochemistry and Cytochemistry1987，35，： | 1 |
| 11 | Approximation by harmonic functions and stability of the Dirichlet problem 显示文摘 | Hedberg L I | 1993 | Exposition Math1993，11，： | 1 |
| 12 | rhBMP-2 release from injectable poly(DL-lactic-co-glycolic acid)/calcium-phosphate cement composites显示文摘 | Ruhe PQ Hedberg EL Padron NT | | 0，，3： | 1 |
| 13 | rhBMP-2 release from injectable poly(DL-lactic-co-glycolic acid)/calcium- phosphate cement composites 显示文摘 | Ruhe PQ Hedberg EL Padron NT | 2003 | J Bone Joint Surg Am2003，85，3： | 1 |
| 14 | Endoglin (CD105) expression in human renal cell carcinoma显示文摘 | Sandlund J Hedberg Y Bergh A | | 0，，04： | 1 |
| 15 | Oil fields of Greater Oficina area,central Anzoategui,Venezuela显示文摘 | Hedberg H D Sass L C Funkhouse H J | 1947 | AAPG Bulletin1947，31，12： | 1 |
| 16 | Endoglin ( CDi05 ) expres- sion in human renal cell carcinoma 显示文摘 | Sandlund J Hedberg Y Bergh A | 2006 | BJU Int2006，97，4： | 1 |
| 17 | Role of gastric acid in stomal ulcer after gastric bypass显示文摘 | Hedberg J HedenstrSm H Nilsson S | 2005 | Obes Surg2005，，13： | 1 |
| 18 | rhBMP-2 release from injectable poly (DL-lactic-co-glycolic acid)/calcium-phosphate cement composites显示文摘 | Hedberg EL Padron NT | 2003 | J Bone Joint Surg Am2003，85，3： | 1 |
| 19 | In vitro biocompatibility of CoCrMo dental alloys fabricated by selective laser melting显示文摘 | HEDBERG Y S QIAN B SHEN Z J | 2014 | Dental Materials2014，30，5： | 1 |
| 20 | Gestational diabetes is associated with depressed adiponectin levels 显示文摘 | Thyfauh JP Hedberg EM Anchan RM | 2005 | J Soc Gynecol Investig2005，12，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员