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| 1 | Monomethyl fumarate augments NK cell lysis of tumor cells through degranulation and the upregulation of NKp46 and CDIO7a显示文摘Dimethyl fumarate (DMF ) 是使用到对待的新药多重硬化(MS ) 病人。这里,我们在生来的杀手(NK ) 的各种各样的活动检验了 DMF 和 DMF 代谢物 monomethyl fumarate (MMF ) 的效果房间。我们证明 MMF 扩充 K562 和 RAJI 肿瘤房间的主要 CD56 +, 然而并非 CD56 −, NK 房间细胞溶解。MMF 为 24 h 在孵化以后在 CD56 +, 然而并非 CD56 −, NK 房间的表面上导致了 NKp46 表示。这效果密切通过这代谢物从这些房间在 CD56 + NK 房间和 Granzyme B 版本的正式就职的表面上与 CD107a 表示的 upregulation 被相关。anti-NKp46 抗体通过 CD56 + NK 房间禁止了 CD107a 的导致 MMF 的 upregulation 和肿瘤房间的细胞溶解。因此,这些结果是第一证明 MMF 扩充肿瘤目标房间的 CD56 + NK 房间细胞溶解,效果通过 NKp46 调停了。这新奇效果在癌症为治疗学或预防的协议建议 MMF 的使用。 | Heidi Vego Kristin L Sand Rune A Hoglund Lars-Egil Fallang Glenn Gundersen Trygve Holmoy Azzam A Maghazachi | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 2 | Aeroponic system for control of root-zone atmosphere显示文摘 | Kratsch Heidi A Graves William R Gladon Richard J | 2006 | Environmental and Experimental Botany2006，55，1： | 1 |
| 3 | Aemponie system for control of root-zone atmosphere显示文摘 | HEIDI A K WILLIAM R G RICHARD J G | 2006 | Environmental and Experimental Botany2006，55，12： | 1 |
| 4 | Motivation for treatment preceding and following a substance abuse program显示文摘 | Melisssa A Cahill BA Heidi HK | 2003 | Addict Behav2003，28，： | 1 |
| 5 | Identification of the DNA Binding specificity and potential target genes for the farnesold X-activated receptor显示文摘 | Bryan A L Heidi R K Catherine M N | 2000 | J Biol Chem2000，275，10： | 1 |
| 6 | Storage stability of freeze-dried starter cultures(Streptococcus thermophilus)as related to physical state of freezing matrix显示文摘 | Astrid B A Mette S F Heidi L et a1 | 1999 | Lebensmittel-Wissenschaft und-Technologie1999，32，： | 1 |
| 7 | Synergistic effect of surface modification and scaffold design of bioplotted 3-D poly- epsilon-eaprolaetone scaffolds in osteogenie tissue engineering 显示文摘 | Heidi A Declercq Tim Desmet | 2013 | Aeta Biomaterialia2013，9，8： | 1 |
| 8 | Aeroponic system for control of root-zone atmosphere 显示文摘 | Heidi A Kratsch * William R Graves Richard J Gladon | 2006 | Environmental and Experimental Botany2006，55，： | 1 |
| 9 | Comparison of pond production efficiency, fatty acid profiles, and Contaminants in Litopenaeus vannamei Fed Organic plant-based and fish- meat-based diets 显示文摘 | CRAIG B GLORIA S HEIDI A | 2006 | Journal of the World Aquaculture Society2006，37，4： | 1 |
| 10 | A Story of Chelatase Evolution: Identification and charaterizatuon of a small 13-15-kDa 'Ancestral'cobaltochelatase in the archaea显示文摘 | Amanda A Brindley Evelyne Raux Helen K. Leech Heidi L. Schubert Martin J.Warren | | 0，，： | 1 |
| 11 | Development of language and speech perception in congenitally,profoundly deaf children as a function of age at cochlear implantation显示文摘 | MARIO A S SU-WOOI T HEIDI N | 2004 | Audiol Neurotol2004，9，： | 1 |
| 12 | β2 -adrenergic receptor Arg16/Arg16 genetype is associated with reduced lung function, but not with asthma,in the hutterites 显示文摘 | Elenor Summerhill Stephanie A Leavitt Heidi Gidley | 2000 | Am J Respir Crit Med2000，162，： | 1 |
| 13 | Ion and solvent transfer discrimination at a nickel hydroxide film exposed to LiOH by combined electrochemical quartz crystal microbalance (EQCM) and probe beam deflection (PBD) techniques显示文摘 | Heidi M French Mark J Henderson A Robert Hillman | | 0，，1： | 1 |
| 14 | Short- term effects of vibration therapy on motor impairments in Parkinson' s disease 显示文摘 | King LK Almeida QJ Heidi A | 2009 | Neurorehabilitation2009，25，： | 1 |
| 15 | Subtractive immunization: a tool for the generation of discr-iminatory antibodies to proteins of similar sequence 显示文摘 | Heidi Major Sleister A Gururaj Rao | 2002 | J Immunological Methods2002，26，12： | 1 |
| 16 | Short-term effects of vibration therapy on motor impairments in Parkinson's disease显示文摘 | King LK Almeida QJ Heidi A | 2009 | Neurorehabilitation2009，25，： | 1 |
| 17 | Safety and feasibility of a CT protocol for acute stroke: combined CT, CT Angiography, and CT perfusion imaging in 53 consecutive patients 显示文摘 | Wade S Heidi C Nathaniel A | 2003 | AJNR2003，24，4： | 1 |
| 18 | Prognostic impact of immuno histochemieally defined germinal center phenotype in dffuse large B-cell lymphoma patients treated with inununochemotherapy显示文摘 | Heidi N Magdalena A Marja L | 2007 | Blood2007，10，11： | 1 |
| 19 | TOPLESS mediates auxin-de- pendent transcriptional repression during Arabidopsis embry- ogenesis显示文摘 | HEIDI S MIKE H JEFF A L | 2008 | Science2008，319，5868： | 1 |
| 20 | Fate of bicuspid aortic valves in patients undergoing aortic root repair or replacement for aortic root enlargement显示文摘 | Gruschen R Heidi M Thomas A | 2006 | Mayo Clin Proc2006，81，3： | 1 |
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