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23篇 您的检索式：作者名="Heiko A"

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	题名	作者	年代	出处	被引量
1	Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs.	Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth	2007	World Journal of Gastroenterology2007，13，48：	4
2	Wave height distributions on shallow foreshores显示文摘	Jurjen A Battjes Heiko W Groenendijk	2000	Coastal Engineering2000，，3：	1
3	TREE - PUZZLE: maximum likelihood phylogenetic analysis using quartets and parallel computing 显示文摘	HEIKO A SCHMIDT	2002	Bioinformatics2002，18，12：	1
4	TPR study on the preparation of impregnated Co/SiO2 catalysts显示文摘	ERIC V S SEWELL G S MAKHOTHE R A MAKHOTHE CRAIG M HEIKO M MARTIJIN D L CYRIL T O	1996	J Catal1996，162，2：	1
5	Decision-mak- ing based on approximate and smoothed Pareto curves显示文摘	Heiner A Alantha N Heiko R	2007	Theoretical Computer Science2007，378，3：	1
6	Dynamic Capability View in Terms of Real Options显示文摘	Kyl(a)heiko K Sandstr(o)m J Virkkunen V		0，，01：	1
7	An analytic approach to production capacity allocation and supply chain design显示文摘	Korpela J Heiko K K Lehmusvaara A	2002	International journal of Production Eco- nomics2002，，78：	1
8	Coronary Arterial Stent Patency:Assessment with Electron-Beam CT显示文摘	Heiko P Stefan M Cornelia A	2000	Radiology2000，214，8：	1
9	A single dose of ceftriaxone administered 30 minutes before percutaneous endoscopic gastrostomy significantly reduces local and systemic infective complications 显示文摘	Dormann A J Bernd Wigginghaus Heiko Risius	1999	American Journal of Gastroenterology1999，94，11：	1
10	Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study显示文摘	Anja Wagner Heiko Mahrholdt Thomas A Holly Michael D Elliott Matthias Regenfus Michele Parker Francis J Klocke Robert O Bonow Raymond J Kim Robert M Judd	2003	The Lancet2003，，9355：	1
11	An analytic approach to production capacity allocation and supply chain design显示文摘	KORPELA J HEIKO K K LEHMUSVAARA A	2002	Production Economics2002，78，：	1
12	Autologous bone-marrow stem-cell transplantation for myocardial regeneration显示文摘	Christof Stamm Bernd Westphal Hans-Dieter Kleine Michael Petzsch Christian Kittner Heiko Klinge Carl Schümichen Christoph A Nienaber Mathias Freund Gustav Steinhoff	2003	The Lancet2003，，9351：	1
13	Foresight supportsystems to facilitate regional innovations: A conceptu-alization case for a German logistics cluster 显示文摘	Keller J MarkmannC Heiko A G	2015	Technological Forecasting Social Change2015，97，：	1
14	Innovation and internationalization as growth strategies:The role of technological capabilities and appropriability显示文摘	KYLHEIKO K JANTUNEN A PUUMALAINEN K	2011	International Business Review2011，20，5：	1
15	A Probabilatistie Model- ling System for Assessing Flood Risks显示文摘	Heiko A Thieken A H and Merz B	2009	Earth and environ- mental science2009，，38：	1
16	,Electrical properties of supported lipid bilayer membranes显示文摘	NOAH A L HEIKO H B etal	2002	J Phys Chem2002，106，：	1
17	Suppression of herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2) 显示文摘	Heiko A Janice L B Nadia C D P	1997	J Exp Med1997，185，9：	1
18	Scenarios for the Lo- gistics Services Industry: A Delphi-Based Analysis for 2025 显示文摘	HEIKO A VONDER GRACHT	2010	Production Economics2010，，127：	1
19	Scenarios for the logistics services industry: A delphi-based analysis for 2025显示文摘	Heiko A Gracht V Darkow I	2010	In- ternational Journal of Production Economics2010，127，：	1
20	Scenarios for the Logistics Services Industry:A Delphi-based Analysis for 2025显示文摘	Heiko A yon der Gracht Inga-Lena Darkow	2010	International Journal of Production Economics2010，127，1：	1

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