|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Utility of different glycemic control metrics for optimizing management of diabetes显示文摘The benchmark for assessing quality of long-term glycemic control and adjustment of therapy is currently glycated hemoglobin(Hb A1c). Despite its importance as an indicator for the development of diabeticcomplications, recent studies have revealed that this metric has some limitations; it conveys a rather complex message, which has to be taken into consideration for diabetes screening and treatment. On the basis of recent clinical trials, the relationship between Hb A1 c and cardiovascular outcomes in long-standing diabetes has been called into question. It becomes obvious that other surrogate and biomarkers are needed to better predict cardiovascular diabetes complications and assess efficiency of therapy. Glycated albumin, fructosamin, and 1,5-anhydroglucitol have received growing interest as alternative markers of glycemic control. In addition to measures of hyperglycemia, advanced glucose monitoring methods became available. An indispensible adjunct to Hb A1 c in routine diabetes care is selfmonitoring of blood glucose. This monitoring method is now widely used, as it provides immediate feedback to patients on short-term changes, involving fasting, preprandial, and postprandial glucose levels. Beyond the traditional metrics, glycemic variability has been identified as a predictor of hypoglycemia, and it might also be implicated in the pathogenesis of vascular diabetes complications. Assessment of glycemic variability is thus important, but exact quantification requires frequently sampled glucose measurements. In order to optimize diabetes treatment, there is a need for both key metrics of glycemic control on a day-to-day basis and for more advanced, user-friendly monitoring methods. In addition to traditional discontinuous glucose testing, continuous glucose sensing has become a useful tool to reveal insufficient glycemic management. This new technology is particularly effective in patients with complicated diabetes and provides the opportunity to characterize glucose dynamics. Several continuous glucose monitoring(CGM) systems, which have shown usefulness in clinical practice, are presently on the market. They can broadly be divided into systems providing retrospective or real-time information on glucose patterns. The widespread clinical application of CGM is still hampered by the lack of generallyaccepted measures for assessment of glucose profiles and standardized reporting of glucose data. In this article, we will discuss advantages and limitations of various metrics for glycemic control as well as possibilities for evaluation of glucose data with the special focus on glycemic variability and application of CGM to improve individual diabetes management. | Klaus-Dieter Kohnert Peter Heinke Lutz Vogt Eckhard Salzsieder | 2015 | World Journal of Diabetes2015，6，1： | 6 |
| 2 | The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4显示文摘 | Brustle A Heink S Huber M | 2007 | Nat Immunol2007，8，9： | 1 |
| 3 | Strain Relaxation in A1GaN/GaN Superlattices Grown on GaN显示文摘 | Einfeldt S Heinke H Kirchner V | 2001 | Journal of Applied Physics2001，89，4： | 1 |
| 4 | Changes in myocardial protein expression in pacing-induced canine heart failure显示文摘 | Heinke MY Wheeler CH Yan JX | 1999 | Electrophoresis1999，20，： | 1 |
| 5 | The Influence of Goal Orientation on Student Satisfaction, Academic Engagement and Achievement显示文摘 | Heinke Roebken | 2007 | Elec- tronic Journal of Research in Educational Psychology2007，5，3： | 1 |
| 6 | MicroRNA-100 regulates neovascularization by suppres- sion of mammalian target of rapamycin in endothelial and vas- cular smooth muscle cells 显示文摘 | Grundmann S Hans FP Kirmiry S Heinke J Helbing T Blubm F et 02 | 2011 | Circulation2011，123，9： | 1 |
| 7 | Chronic hyperglycemia but not glu- cose variability determines HbAlc levels in well-controlled patients with type 2 diabetes显示文摘 | Kohnert KD Augstein P Heinke P | 2007 | Diabetes Res Clin Pract2007，77，： | 1 |
| 8 | 显示文摘 | Heinke H Kirchner V Einfeldt S | 2000 | Appl Phys Lett2000，77，： | 1 |
| 9 | The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells显示文摘 | Drube S Heink S Walter S | 2010 | Blood2010，115，19： | 1 |
| 10 | 'X-ray diffraction analysis of the defect structure in epitaxial GaN'显示文摘 | Heinke H Kirchner V Einfeldt S | 2000 | APL2000，77，14： | 1 |
| 11 | Kinetic Model for the Formation of CaO and CaS in Aluminum Deoxidized Steel by Calcium Treatment显示文摘 | Heinke R | 1987 | Steel Research1987，58，： | 1 |
| 12 | Endocrinedisrupting non- ylphenols are ubiquitous in food 显示文摘 | Guenther K Heinke V Thiele B | 2002 | Environ Sci Technol2002，36，3： | 1 |
| 13 | The use of a computer profil to calculate the mean amplitude of glycemic excursis显示文摘 | Fritzsche G Kohnert K D Heinke P | 2011 | Diabetes Technol Ther2011，13，3： | 1 |
| 14 | The development of inflammatory T(H)-17 cells requires interferon-regulatory factor4显示文摘 | Brüstle A Heink S Huber M | 2007 | Nat Immunol2007，8，2： | 1 |
| 15 | Synaptic plasticity in spinal lamina Ⅰ projection neurons that mediate hyperalgesia显示文摘 | Ikeda H Heinke B Ruscheweyh R | 2003 | Science2003，299，： | 1 |
| 16 | Apoptosis of ventricular and atrial myocytes from pacing-induced canine heart failure显示文摘 | Heinke MY Yao M Chang D | | 0，，01： | 1 |
| 17 | In vivo imaging of anaesthetic ac- tion in humans: approaches with positron emission tomography and functional magnetic resonance imaging 显示文摘 | Heinke W Schwarzbauer C | 2002 | Br J Anaesth2002，89，： | 1 |
| 18 | Vaginoplasty with oxidized cellulose : anatomical, functional and histological evaluation 显示文摘 | Domelas J J6rmy -Di Bella ZI Heinke T | 2012 | Eur J Obstet Gynecol Reprod Biol2012，163，2： | 1 |
| 19 | Cerebral activation to intranasal chemosensory trigeminal stimulation 显示文摘 | Boyle JA Heinke M Gerber J | 2007 | Chem Senses2007，32，4： | 1 |
| 20 | Multimodel assessment of water scarcity under climate change显示文摘 | Schewe J Heinke J Gerten D | 2014 | Proceedings of the National Academy of Sciences of the United States of America2014，111，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员