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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | Comparison between different LiFePO4 synthesis routes and their influence on its physico-chemical properties显示文摘 | SLVSIN F FREDEREC L C CAROLE B HELENE R | 2003 | J Power Source2003，，： | 1 |
| 3 | Three-Dimensional Culture of Annulus Fibrosus Cells within PDLLA/Bioglass ? Composite Foam Scaffolds; Assessment of Cell Attachment, Proliferation and Extracellular Matrix Production 显示文摘 | Helen W Merry C L R Blaker J J | 2007 | Biomaterials2007，28，11： | 1 |
| 4 | Physiological responses of cabbage to incipient copper toxicity显示文摘 | Penelope A R Helen C H Kenneth L S | 1989 | J Amer Soc Hor Sci1989，114，1： | 1 |
| 5 | Defining Spinal Mobility in Ankylosing Spondylitis (AS):The Bath AS Metrology Index显示文摘 | TIM R JENKINSON PATRICIA A MALLORIE HELEN C WHITELOCK | 1994 | Journal of Rheumatology1994，21，9： | 1 |
| 6 | Human chorionic gonadotrophin relaxation of human pregnant myometrium and activation of the BKCa channel显示文摘 | Helen C D Diarmaid D H Nandini R | 2003 | The Journal of Clinical Endocrinology & Metabolism2003，88，9： | 1 |
| 7 | Heparin binding domain in vitronectin is required for oligomerization and thus enhances integrin mediated cell adhesion and spreading显示文摘 | Chandramouli R Chillakuri Céline Jones Helen J Mardon | 2010 | FEBS Letters2010，，15： | 1 |
| 8 | A formal model for consensus and negotiation in environmental management显示文摘 | HELEN M R MAR K C LISA M N | 2006 | Journal of Environmental Management2006，80，2： | 1 |
| 9 | Biodegrada- fion processes in a laboratory - scalegroundwater contaminant plume assessed by fluorescence imaging and microbial analysis 显示文摘 | HELEN C R SASCHA E O STEVEN A B | 2007 | Appl Environ Microbiol2007，73，12： | 1 |
| 10 | Biodegradation processes in a laboratory - scale groundwater contaminant plume assessed by fluores- cence imaging and microbial analysis 显示文摘 | HELEN C R SASCHA E O STEVEN A B | 2007 | Appl Envi- ron Microbiol2007，73，12： | 1 |
| 11 | Physiological responses of cabbage to incipient copper toxicity显示文摘 | Penelope A R Helen C H Kennethl L S | 1989 | Amer Soc Hor Sci1989，114，1： | 1 |
| 12 | Role of external signals in regulating the pre-penetration phase of infection by the rice blast fungus, Magnaporthe grisea显示文摘 | Till C J Helen A P Nick D R | 1994 | Planta1994，194，4： | 1 |
| 13 | Biodegradation processes in a laboratory-scale groundwater contaminant plume assessed by fluorescence imaging and microbial analy- sis显示文摘 | Helen C R Sascha E O Steven A B | 2007 | Applied and Environmental Microbiology2007，73，12： | 1 |
| 14 | Cesium toxicity in arabidopsis 显示文摘 | Hampton Corrina R Helen C | 2004 | Plant Physiology2004，136，： | 1 |
| 15 | Early effects of paraquat on plasma corticosteroid concentrations in rats显示文摘 | Helen C C Michael S R | 1976 | Biochemical Pharmacology1976，25，： | 1 |
| 16 | Modeling gas flow through micro-channels and nano-pores 显示文摘 | SUBRATA R RENI R HELEN C F | 2003 | Journal of Applied Physics2003，93，8： | 1 |
| 17 | Impact of vertical atmospheric structure on Beijing aerosol distribution 显示文摘 | Benjamin G Jean-Claude R Helene C | 2006 | Atmospheric Environment2006，40，27： | 1 |
| 18 | Cloning, bacterial expression, purification and structural characterization of N-terminal-repetitive domain of γ-Gliadin显示文摘 | Claudia G Benitez C Helene R | 2006 | Protein Expression and Purification2006，，46： | 1 |
| 19 | Monogenic hypercholesterolemia:new insights in pathogensis and treatment显示文摘 | DANIEL J R JONATHAN C HELEN H H | 2003 | J Clin Invest2003，111，： | 1 |
| 20 | Benefit of long - term dual anti-platelet therapy in patients treated with drug- eluting stents: from the NHLBI dynamic registry 显示文摘 | Suresh R Oscar C Helen A | 2013 | Am J Cardiol2013，111，： | 1 |
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