|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alcoholic liver disease and hepatitis C:A frequently underestimated combination显示文摘Alcoholic liver disease(ALD) and hepatitis C virus(HCV) infection represent, either alone or in combination, more than two thirds of all patients with liver disease in the Western world.This review discusses the epidemiology and combined impact of ALD and HCV on the progres sion of liver disease.ALD and HCV affect the progres sion of liver disease to liver cirrhosis and hepatocellular carcinoma(HCC) in a synergistic manner.Thus, the risk for HCC increases f ive times with a daily alcohol con sumption of 80 g;in the presence of HCV it is increased 20fold, and a combination of both risk factors leads to a more than 100fold risk for HCC development.Alcohol consumption also decreases the response to interferon treatment which is probably due to a lack of compliance than a direct effect on HCV replication.Several molecu lar mechanisms are discussed that could explain the synergistic interaction of alcohol and HCV on disease progression.They include modulation of the immune response and apoptosis, increased oxidative stress via induction of CYP2E1 and the hepatic accumulation of iron.Thus, both HCV and alcohol independently cause hepatic iron accumulation in > 50% of patients probably due to suppression of the liversecreted systemic iron hormone hepcidin.A better understanding of hepcidin regulation could help in developing novel therapeutic approaches to treat the chronic disease in the future.For now, it can be generally concluded that HCVinfect ed patients should abstain from alcohol and alcoholicsshould be encouraged to participate in detoxification programs. | Sebastian Mueller Gunda Millonig Helmut K Seitz | 2009 | World Journal of Gastroenterology2009，15，28： | 18 |
| 2 | Is laparoscopic colorectal cancer surgery equal to open surgery? An evidence based perspective显示文摘Laparoscopic colorectal surgery(LCS) is an evolving subject.Recent studies show that LCS can not only offer safe surgery but evidence is growing that this new technique can be superior to classical open procedures.Fewer perioperative complications and faster postoperative recovery are regularly mentioned when studies of LCS are presented.Even though the learning curve of LCS is frequently debated when limitations of laparoscopic surgeries are reviewed,studies show that in experienced hands LCS can be a safe procedure for colorectal cancer treatment.The learning curve however,is associated with high conversion rates and economical aspects such as higher costs and prolonged hospital stay.Nevertheless,laparoscopic colorectal cancer surgery(LCCR) offers several advantages such as less co-morbidity and less postoperative pain in comparison with open procedures.Furthermore,the good exposure of the pelvic cavity by laparoscopy and the magnification of anatomical structures seem to facilitate pelvic dissection laparoscopically.Moreover,recent studies describe no difference in safety and oncological radicalness in LCCR compared to the open total mesorectal excision(TME).The oncological adequacy of LCCR still remains unproven today,because long-term results do not yet exist.To date,only a few studies have described the results of laparoscopic TME combined with preoperative adjuvant treatment for colorectal cancer.The aim of this review is to examine the various areas of development and controversy of LCCR in comparison to the conventional open approach. | Beat M Künzli Helmut Friess Shailesh V Shrikhande | 2010 | World Journal of Gastrointestinal Surgery2010，2，4： | 3 |
| 3 | Gangliogliomas:clinical,radiological,and histopathological findings in 51 patients显示文摘 | Josef Zentner Helmut K Wolf Burkhard Ostertun | 1994 | Journal of Neurology1994，，： | 1 |
| 4 | Social Origins of Civil Society: Explaining the Nonprofit Sector Cross- Nationally显示文摘 | SALAMON L M HELMUT K A | 1998 | Voluntas1998，9，3： | 1 |
| 5 | Magnetic induction tomography: hardware for multi-frequency measurements in biological tissues 显示文摘 | SCHARFETTER H HELMUT K L JAVIER R | 2001 | Physiol Meas2001，22，1： | 1 |
| 6 | Metallurgy and processing of high-integrity light metal pressure castings显示文摘 | HELMUT K UGGOWITZER P J | 2007 | Aluminium2007，83，78： | 1 |
| 7 | Pros and cons of a pushover analysis of seismic performance evaluation显示文摘 | HELMUT KRAWINKLER SENVIRATNA G D K | 1998 | Engineering Structures1998，20，4： | 1 |
| 8 | Tumor necrosis factor-α contributes to ischemia and reperfusion induced endothelial activation in isolated hearts显示文摘 | Christian K Helmut H Axel G | 1999 | Cirs Res1999，84，： | 1 |
| 9 | Intraoperative magnetic resonance imaging combined with neuronavigation:a new concept显示文摘 | Christopher N Oliver G Helmut K | 2001 | Neurosurgery2001，48，5： | 1 |
| 10 | Infraredspectroscopic investigations of selective catalytic reduction catalysts poisoned with arsenic oxide显示文摘 | FRIEDERIKE C L HELMUT S HELMUT K | 1996 | Appl Catal B1996，8，24： | 1 |
| 11 | An X-ray photo electron spectroscopy study of oxides of arsenic supported on Ti O2显示文摘 | FRIEDERIKE C L HELMUT S HELMUT K | 1991 | J Electron Spectrosc1991，57，30： | 1 |
| 12 | How to calculate and interpret ecological footprints for long periods of time : the case of Austria 1926 - 1995 显示文摘 | Helmut H Karl H B Fridolin K | 2001 | Ecological Economics2001，38，： | 1 |
| 13 | Pros and cons analysis of seismic evaluation of a pushover performance 显示文摘 | Helmut Krawinkler Seneviratna G D P K | 1998 | Engineering Structures1998，20，46： | 1 |
| 14 | Interaction of arsenious oxide with De NOx-catalysts:An X-ray absorption and difuse reflectance infrared spectroscopy study显示文摘 | FRANK H HERBERT E G HELMUT K | 1991 | J Catal1991，129，16： | 1 |
| 15 | Effect of the nature of metallocene complexes of group Ⅳ metals on their performance in catalytic ethylene and propylene polymerization 显示文摘 | Helmut GAlt Alexander K | 2000 | Chem Rev2000，100，： | 1 |
| 16 | Intraoperative magnetic resonance imaging combined with neuronavigation: a new concept 显示文摘 | Christopher N Oliver G Helmut K | 2001 | Neurosurgery2001，48，5： | 1 |
| 17 | Pros and cons of a pushover analysis of seismic performance evaluation显示文摘 | Helmut K | 1998 | Engineering Structures1998，20，4： | 1 |
| 18 | Histopathologic features of early (patch) lesions of mycosis fungoides显示文摘 | Cesare M Kazuo K Helmut K | | 0，，： | 1 |
| 19 | Color measurement methods and systems in printing technology and graphic arts显示文摘 | Helmut K | 1992 | SPIE1992，，： | 1 |
| 20 | Intraoperative magnetic resonance imaging combined with neuronavigation: a new concept 显示文摘 | Christopher N Oliver G Helmut K | 2001 | Neurosurgery2001，48，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员