|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 2 | Cmos image sensors显示文摘 | ABBAS E G HELMY E | 2005 | IEEE Circuits & Devices Magazine2005，，56： | 1 |
| 3 | Fertility outcomes fol-lowing expectant management of tubal ectopic pregnancy 显示文摘 | Helmy S Sawyer E Ofili - Yebovi D | 2007 | Ul-trasound Obstet Gynecol2007，30，7： | 1 |
| 4 | A retrospective hospital study of human cystic echinoeoeeosis in Egypt 显示文摘 | Kandeel A Ahmed E S Helmy H | 2004 | East Mediterr Health J2004，10，3： | 1 |
| 5 | Aprospective study of antituberculous drug-induced hepatotoxicity in an area en- demic for liver diseases显示文摘 | Makhlouf HA Helmy A Fawzy E | 2008 | Hepatol Int2008，2，3： | 1 |
| 6 | A prospective study of antituberculous drug-induced hepatotoxicity in an area endemic for liver diseases显示文摘 | Makhlouf HA Helmy A Fawzy E | 2008 | Hepatol Int2008，2，3： | 1 |
| 7 | A prospective study of antituberculous drug-induced hepatotoxicity in an area endemic for liver diseases 显示文摘 | Makhlouf HA Helmy A Fawzy E | 2008 | Hepatol Int2008，2，3： | 1 |
| 8 | The surface energy of palygorskite 显示文摘 | Helmy A K Bussetti S G Ferreiro E A | 2007 | Powder Technology2007，171，： | 1 |
| 9 | Cut-off value of initial serumβ-h CG level predicting a successful MTX therapy in tubal ectopic pregnancy:a retrospective cohort study显示文摘 | Helmy S Bader Y Pablik E | 2014 | Eur J Obst Gynecol Reprod Biol2014，179，03： | 1 |
| 10 | Fertility outcomes following expectant management of tubal ectopic pregnancy 显示文摘 | Helmy S Sawyer E Ofili-Yebovi D | 2007 | Ultrasound Obstet Gynecol2007，30，： | 1 |
| 11 | Role of interleukin 6 and alpha-globulins in difl'erentiating Alzheimer and vascular dementias 显示文摘 | HELMY A A NASEER M M SHAFIE S E | 2012 | Neurodegener Dis2012，9，2： | 1 |
| 12 | Cut-off value of initial serum β-hCG level predicting a successful MTX therapy in tubal ectopic pregnancy: a retrospective cohort study 显示文摘 | HELMY S BADER Y PABLIK E | 2014 | Eur J Obstet Gynecol Reprod Biol2014，12，34： | 1 |
| 13 | Role of interleukin 6 and apha-globulins in differentiating Alzheimer and vascular dementias 显示文摘 | HELMY A A NASEER M M SHAFIE S E | 2012 | Neurodegener Dis2012，9，2： | 1 |
| 14 | Osteoarthrosis of the temporomandibular joint following experimental disc perforation in Macaca fascicularis 显示文摘 | Helmy E Bays R Sharawy M | 1988 | J Oral Maxillofac Surg1988，46，11： | 1 |
| 15 | Molybdate sorption by oxides of aluminium and iron显示文摘 | FERREIRO E A HELMY A K BUSSETTI S G | 1985 | Earth and Environmental Science : General1985，148，5： | 1 |
| 16 | Bioremediation of aged petroleum oil contaminated soil:from laboratory scale to full scale application显示文摘 | HELMY Q LAKSMONO R KARDENA E | 2015 | Procedia Chemistry2015，14，： | 1 |
| 17 | Determination of surface area of soil by adsorption methods显示文摘 | FERREIRO E A de BUSSETTI S G HELMY A K | 2002 | Eur J Soil Sci2002，53，： | 1 |
| 18 | A prospective study of antitubereulous drug-induced hepatotoxicity in an area endemic for liver diseases 显示文摘 | Makhlouf H A Helmy A Fawzy E | 2008 | Hepatol Int2008，2，3： | 1 |
| 19 | Production of levansucrase from novel honey Bacillus subtilis isolates capable of producing antiviral levans显示文摘 | Esawy M A Ahmed E F Helmy W A | | 0，，02： | 1 |
| 20 | A prospective study of anti- tuberculous drug-induced hepatotoxicity in an area endemic for liver diseases显示文摘 | Makhlouf HA Helmy A Fawzy E | 2008 | Hepatol Int2008，2，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员