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| 1 | 肥大细胞源性组织蛋白酶G在狭窄主动脉瓣不良改变中的可能作用显示文摘Aims: Aortic stenosis(AS) is characterized by extensive remodelling of the valves, including infiltration of inflammatory cells, extracellular matrix degradation, and fibrosis. The molecular mechanisms behind this adverse remodelling have remained obscure. In this article, we study whether cathepsin G, an angiotensin Ⅱ(Ang Ⅱ)forming elastolytic enzyme, contributes to progression of AS. Methods and results: Stenotic aortic valves(n=86) and control valves(n=17) were analysed for cathepsin G, transforming growth factor-β1(TGF-β1), and collagens I and Ⅲ with RT-PCR and immunohistochemistry. Valvular collagen/elastin ratio was quantified by histochemistry. In stenotic valves, cathepsin G was present in mast cells and showed increased expression(P< 0.001), which correlated positively(P< 0.001)with the expression levels of TGF-β1 and collagens I and Ⅲ. TGF-β1 was also present in mast cell rich areas and cathepsin G induced losartan-sensitive TGF-β1 expression in cultured fibroblasts. Collagen/elastin ratio was increased in stenotic valves(P< 0.001) and correlated positively with smoking(P=0.02). Nicotine in cigarette smoke activated mast cells and induced TGF-β1 expression in cultured fibroblasts. Fragmented elastin was observed in stenotic valves containing activated cathepsin G-secreting mast cells and in normal valves treated with cathepsin G. Conclusion: In stenotic aortic valves, mast cell-derived cathepsin G may cause adverse valve remodelling and AS progression. | Helske S. Syvranta S. Kupari M. K.A. Lindstedt 郭俊 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，，12： | 7 |
| 2 | Low circulating levels of gastrin-17 in patients with Barrett's esophagus显示文摘AIM: To examine whether the fasting levels of serum gastrin-17 (G-17) are lower in Barrett's esophagus (BE)patients than in non-Barrett controls.METHODS: Nineteen patients with BE (presenting with a tubular segment ≥2 cm long in lower esophagus and intestinal metaplasia of incomplete type ('specialized columnar epithelium') in endoscopic biopsies from the tubular segment below the squamocolumnar junction were collected prospectively from outpatients referred to diagnostic gastroscopy. The controls comprised 199 prospectively collected dyspeptic outpatients without BE or any endoscopically visible lesions in the upper GI tract.Fasting levels of serum G-17 (G-17fast) were assayed with an EIA test using a Mab highly specific to amidated G-17. None of the patients and controls received therapy with PPIs or other antisecretory agents.RESULTS: The mean and median levels of G-17fast in serum were significantly lower (P = 0.001) in BE patients than in controls. The positive likelihood ratios (LR+) of low G-17fast to predict BE in the whole study population at G-17fast levels <0.5, <1, or <1.5 pmol/L were 3.5, 3.0,and 2.8, respectively. Among patients and controls with healthy stomach mucosa, the LR+ were 5.6, 3.8, and 2.6,respectively. In the whole study population, serum G-17 was below 2 pmol/L in 15 of 19 BE patients (79%). The corresponding prevalence was 66 of 199 (33%) in controls (P<0.001). The G-17fast was 5 pmol/L or more in only one of the 19 BE patients (5%). In controls, 76 of the 199 patients (38%) had such high serum G-17fast levels (P<0.01).CONCLUSION: Serum levels of G-17fast tend to be lower in native patients with BE than in healthy controls. | Pentti Sipponen Matti Vauhkonen Timo Helske Ilpo Kriinen Matti Hrknen | 2005 | World Journal of Gastroenterology2005，11，38： | 6 |
| 3 | Changes in the life ex- pectancy of patients with severe, haemophilia A in Finland in 1930 - 1979显示文摘 | Ikkala E Helske T MyUyla G | 1982 | Br J aematol1982，52，1： | 1 |
| 4 | Increased circulating concentrations and augmented myocardial extraction of osteoprotegerin in heart failure due to left ventricular pressure overload显示文摘 | Helske S Kovanen PT Lindstedt KA | 2007 | Eur J Heart Fail2007，9，5： | 1 |
| 5 | Serum levels of amidated gastrin-17 and pepsinogen I in atrophic gastritis:an observational case-control study显示文摘 | Sipponen P Ranta P Helske T | 2002 | Scand J Gastroenterol2002，，7： | 1 |
| 6 | Receptors for the anaphylatoxins C3a and C5a are expressed in human atherosclerotic coronary plaques 显示文摘 | Oksjoki R Laine P Helske S | 2007 | Atherosclerosis2007，195，1： | 1 |
| 7 | Induction of local angiotensin II-producing systems in stenotic aortic valves显示文摘 | Helske S Lindstedt KA Laine M | 2004 | J Am Coll Cardiol2004，44，9： | 1 |
| 8 | Expression of vascular endothelial growth factor receptors 1,2 and 3 in placentas from normal and complicated pregnancies显示文摘 | Helske S Vuorela P Carpen O | 2001 | Molecular Human Rrproduction2001，7，2： | 1 |
| 9 | Complement system is activated in stenotic aortic valves 显示文摘 | Helske S Oksjoki R Lindstedt KA | 2008 | Athero- sclerosis2008，196，1： | 1 |
| 10 | Induction of local angio- tensin II-producing systems in stenotic aortic valves 显示文摘 | Helske S Lindstedt KA Laine M | 2004 | J Am Coll Cardiol2004，44，9： | 1 |
| 11 | Amniotic fluid-soluble vascular endothelial growth factor receptor-1 in preeclampsia 显示文摘 | Vuorela P Helske S Hornig C | 2000 | Obstet Gynecol2000，95，3： | 1 |
| 12 | Expression of vascular endothelial growth factor receptors 1,2 and 3 in placentas from normal and complicated pregnancies显示文摘 | Helske S Vuorela P Carpen O | 2001 | Mol Hum Reprod2001，7，2： | 1 |
| 13 | Norepinephrine,adrenocortieotropin,eortisol and beta-endorphin in women suffering from fear of labor:responses to the cold pressor test during and after pregnancy显示文摘 | Saisto T Kaaja R Helske S | | 0，，1： | 1 |
| 14 | Lipid lowering in aortic stenosis: still some light at the end of the tunnel? 显示文摘 | Helske S Otto CM | 2009 | Circulation2009，119，20： | 1 |
| 15 | Norepinephrine, adrenocorticotropin, cortisol and beta-endorphin in women suffering from fear of labor: responses to the cold pressor test during and after pregnancy显示文摘 | Saisto T Kaaja R Helske S | 2004 | Acta Obstet Gynecol Scand2004，83，1： | 1 |
| 16 | Changes in the life expectancy of patients with severe haemophilia A in Finland in 1930-1979显示文摘 | Ikkala E Helske T Myllyla G | 1982 | Br J Haematol1982，52，1： | 1 |
| 17 | Aortic valve stenosis: an active atheros inflammatory process显示文摘 | Helske S Kupari M Lindstedt KA | 2007 | Curr Opin Lipidol2007，18，5： | 1 |
| 18 | Increased expres- sion of elastolytic cathepsins S, K, and V and their inhibitor cystatin C in stenotic aortic valves 显示文摘 | Helske S Syv~iranta S Lindstedt KA | 2006 | Arterioscler Thromb Vasc Biol2006，26，8： | 1 |
| 19 | Aortic value stenosis an active atheros inflammatory process显示文摘 | Helske S Kupari M Lindstedt KA | 2007 | Curt Opin Lipido12007，18，： | 1 |
| 20 | Norepinephrine, adreno-cortieotropin,eortisol and beta-endorphin in women suffering from fear of labor:responses to the cold pressor test during and after pregnancy显示文摘 | Saisto T Kaaja R Helske S | 2004 | Aeta Obstet Gynecol Scand2004，83，1： | 1 |
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