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3篇 您的检索式:作者名="Hend Sayed"
    题名 作者 年代 出处 被引量
1An Interactive Algorithm for Decomposing the Parametric Space in Fuzzy Multi-objective Dynamic Programming Problem显示文摘Mahmoud A Abo-sinna A H Amer Hend H EI Sayed 2005Applied Mathematics and Computation2005,107,4:1
2Glutathione disrupts galectin-10 Charcot-Leyden crystal formation to possibly ameliorate eosinophil-based diseases such as asthma显示文摘Charcot-Leyden crystals(CLCs)are the hallmark of many eosinophilic-based diseases,such as asthma.Here,we report that reduced glutathione(GSH)disrupts CLCs and inhibits crystallization of human galectin-10(Gal-10).GSH has no effect on CLCs from monkeys(Macaca fascicularis or M.mulatta),even though monkey Gal-10s contain Cys29 and Cys32.Interestingly,human Gal-10 contains another cysteine residue(Cys57).Because GSH cannot disrupt CLCs formed by the human Gal-10 variant C57A or inhibit its crystallization,the effects of GSH on human Gal-10 or CLCs most likely occur by chemical modification of Cys57.We further report the crystal structures of Gal-10 from M.fascicularis and M.mulatta,along with their ability to bind to lactose and inhibit erythrocyte agglutination.Structural comparison with human Gal-10 shows that Cys57 and Gln75 within the ligand binding site are responsible for the loss of lactose binding.Pull-down experiments and mass spectrometry show that human Gal-10 interacts with tubulinα-1B,with GSH,GTP and Mg^(2+)stabilizing this interaction and colchicine inhibiting it.Overall,this study enhances our understanding of Gal-10 function and CLC formation and suggests that GSH may be used as a pharmaceutical agent to ameliorate CLC-induced diseases.Heya Na Hend Sayed Gabriela Jaramillo Ayala Xing Wang Yuhan Liu Jinyi Yu Tianhao Liu Kevin H.Mayo Jiyong Su 2023Acta Biochimica et Biophysica Sinica2023,55,4:0
3Analysis of Reactivity Induced Accident for Control Rods Ejection with Loss of Cooling显示文摘Hend Mohammed El Sayed Saad Hesham Mohammed Mohammed Mansour Moustafa Aziz Abd ElWahab 2013材料科学与工程(中英文B版)2013,3,2:0
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