2篇
您的检索式：作者名="Henghui Fan"
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| 1 | The mutational pattern of homologous recombination(HR)-associated genes and its relevance to the immunotherapeutic response in gastric cancer显示文摘Objective:Currently,there is an urgent need to identify immunotherapeutic biomarkers to increase the benefit of immune checkpoint inhibitors(ICIs)for patients with gastric cancer(GC).Homologous recombination deficiency(HRD)can modify the tumor immune microenvironment by increasing the presence of tumor-infiltrating lymphocytes and therefore might serve as a biomarker of immunotherapeutic response.We aimed to analyze the mutational pattern of HR-associated genes in Chinese patients with GC and its relevance to the tumor immune profile and clinical immunotherapeutic response.Methods:A panel of 543 cancer-associated genes was used to analyze genomic profiles in a cohort comprising 484 Chinese patients with GC.Correlations between HR gene mutations and tumor immunity or clinical outcomes were identified via bioinformatic analysis using 2 GC genomic datasets(TCGA and MSK-IMPACT).Results:Fifty-one of the 484(10.54%)patients carried at least one somatic mutation in an HR gene;ATM(16/484,3.31%)was among the most frequently mutated HR genes in the Chinese cohort.Mutations in HR genes were associated with elevated tumor mutational burden,enhanced immune activity,and microsatellite instability status.In the MSK-IMPACT cohort comprising 49 patients with stomach adenocarcinoma or gastroesophageal junction adenocarcinoma treated with ICIs,patients with HR-mut GC(n=12)had significantly better overall survival than those with HR-wt GC(n=37)(log-rank test,P<0.05).Conclusions:Our data suggest that detection of somatic mutations in HR genes might aid in identifying patients who might benefit from immune checkpoint blockade therapy. | Yue Fan Haifeng Ying Xueying Wu Huan Chen Ying Hu Henghui Zhang Lijia Wu Ying Yang Beibei Mao Lan Zheng | 2020 | Cancer Biology & Medicine2020，17，4： | 6 |
| 2 | Effect of soaking time of dithionite-citrate-bicarbonate solution on strength and deformation characteristics of lateritic soil显示文摘This study aimed to reveal the influence of different free-iron-oxides contents on the strength and deformation characteristics of in situ lateritic soil.A test method that combined the selective chemical dissolution method and in situ Ménard pressuremeter test(PMT)was proposed.The soaking time in dithioniteecitrateebicarbonate(DCB)solution was used as a variable to control the free-iron-oxides content in lateritic soil.Then,the in situ lateritic soil boreholes with different soaking time were tested by PMT.The results showed that the in situ horizontal pressure p0,critical edge pressure pf,ultimate pressure prediction pl,pressuremeter modulus Em,shear modulus Gm,and foundation-bearing capacity f0k of lateritic soil decreased rapidly after immersing in DCB solution within 1e4 d.With increasing soaking time,the decrease rate reduced gradually.Moreover,the relationship curve between free-iron-oxides content and soaking time declined rapidly and then stabilized,and the free-iron-oxides content at the inflection point was 30.11 g/kg.When the free-iron-oxides content changed to the inflection point,the free-iron-oxides that played a cementing role was largely removed,indicating that the effective cementing iron-content of Miaoling lateritic soil was about 52.9%.This study demonstrated that the proposed test method can determine the influence of free-iron-oxides content on the strength and deformation characteristics of lateritic soil. | Wei Bai Wenbo Zhang Lingwei Kong Henghui Fan Aiguo Guo Guofang Xu | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，11： | 0 |
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