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| 1 | 小窝蛋白-1、基质金属蛋白酶-2在膀胱癌的表达及其关系(英文)显示文摘Objective: To explore the expression of caveolin-1 (CAV-1) and matrix metalloproteinase-2 (MMP-2) in bladder cancer and its clinical significance. Methods: The expression of CAV-1 and MMP-2 were detected by the SP immunohis- tochemical method in 77 cases of bladder cancer. Results: The positive rates of CAV-1, MMP-2 in bladder transitional cell carcinoma (BTCC) and bladder adenocarcinoma were significantly high than those of normal bladder mucosa, the positive rates in the deeper cancer invasion was significantly high than those of superficial bladder cancer (P < 0.01), the positive rates of CAV-1 in grades I, II and III of bladder transitional cell carcinaoma (BTCC) were 15%, 40% and 68%, respectively; the positive rates of MMP-2 in grades I , II and III of bladder transitional cell carcinoma (BTCC) were 20% , 40% and 72%, respectively (P < 0.01). CAV-1 was positive associated with MMP-2 in bladder cancer (r = 0.598, P < 0.001), but not in bladder tissue. Conclusion: CAV-1 and MMP-2 were associated with stage and grade of bladder cancer, which suggested that CAV-1 might improve secretion of MMP-2. | Hengping Li Yirong Chen Dongwen Yan | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，6： | 3 |
| 2 | 甲状腺滤泡状癌危险组与淋巴结微转移的相关性(英文)显示文摘Objective:The aim of this study was to explore the relationship between follicular carcinoma of thyroid in different risk groups and lymph node micrometastases.Methods:The keratin-19 of negative neck lymph nodes in 83 cases in routine pathological examination,was detected by SP immunohistochemistry using keratin-19 monoclonal antibody to confirm lymph node micrometastases.All of cases are divided into high risk group,middle risk group and low risk group according to factors related prognosis,the relationship between lymph node micrometastases and different risk groups and follow-up visit documents were analyzed.Results:Fifty-eight neck lymph nodes in 16 cases of 83 cases(19.3%) showed positive lymph node micrometastases,and incidence of lymph node micrometastases was 4/39 in low risk group,5/32 in middle risk group and 7/12 in high risk group,respectively.it showed remarkable difference during 3 groups(P < 0.001).Nine patients in 16 cases with positive lymph node micrometastases showed local recurrence and distant metastases,6 patients in 67 cases with negative lymph node micrometastases showed same result(P < 0.001).Conclusion:Lymph node micrometastases in follicular thyroid carcinoma closely correlated to factors related to prognosis.The detection of lymph node micrometastases can directly assistant postoperative treatment and prognosis evaluation to some extent for follicular thyroid carcinoma. | Qinjiang Liu Youxin Tian Hengping Li | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，12： | 0 |
| 3 | 射频联合^(131)I治疗失分化甲状腺癌的临床研究(英文)显示文摘Objective:The aim of this study was to explore clinical efficiency of radio frequency combined with 131I therapy for dedifferentiated thyroid carcinoma.Methods:All patients have been treated by radiofrequency connected with 131I in 29 cases of dedifferentiated thyroid carcinoma which performed radionuclide imaging and Ig array of blood serum before and after therapy,respectively.Results:There were 4(4/29) positive cases of radionuclide imaging before treatment and 19(19/29) cases 2 weeks after therapy,25(25/29) cases of overall efficacy and 15(15/29) curative cases. Conclusion: Radiofrequency connected with 131I improve clinical efficacy of 131I treatment for dedifferentiated thyroid cancer of thyroid in view of higher absorbing 131I of thyroid cancerous cell. | Hengping Li Qinjiang Liu Feng Dong | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，5： | 0 |
| 4 | 甲状腺滤泡状癌淋巴结徽转移与中央区淋巴结处理(英文)显示文摘Objective: We evaluated the relationship between the clinical management of level VI lymph node and neck lymph node micrometastases in follicular thyroid carcinoma. Methods: 326 negative neck lymph nodes of 68 cases with follicular thyroid carcinoma on routine pathology were examined by keratin-19 monoclonal antibody and S-P immunohisto- chemistry to confirm lymph node micrometastasis. Follow-up pathological and clinical documents were compared. Results: Forty-six neck lymph nodes showed positive micrometastasis among 326 negative neck lymph nodes including 4 lymph nodes in Level II (4/42), 5 lymph nodes in Level III (5/34), 5 lymph nodes in Level IV (5/49), 1 lymph node in Leve IV (1/17) and 31 lymph nodes in Level VI (31/184). Six in 14 cases with positive micrometastasis showed distant metastasis or local recurrence, but only 3 in 54 cases with negative micrometastasis indicated distant metastasis or local recurrence (P < 0.01). Conclusion: The research showed that Level VI neck lymph node micrometastasis is possibly occur and closely related with local recurrence and metastasis in follicular carcinoma of thyroid. | Qinjiang Liu Hengping Li Youxin Tian | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，7： | 0 |
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