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| 1 | Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor显示文摘AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on in-hospitalmortality.RESULTS: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria. | Mireen Friedrich-Rust Beate Wanger Florian Heupel Natalie Filmann Reinhard Brodt Volkhard AJ Kempf Johanna Kessel Thomas A Wichelhaus Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 2 | Far field potentials from brain stem after transcutaneous vagus nerve stimulation显示文摘 | Fallgatter AJ Neuhauser B Herrmann MJ | 2003 | J Neural Transm2003，10，12： | 1 |
| 3 | Circulating humanin levels are associated with preserved coronary endothelial function 显示文摘 | Widmer RJ Flammer AJ Herrmann J | 2013 | Am J Physiol Heart Circ Physiol2013，304，3： | 1 |
| 4 | Early-stage face processing dysfunction in patients with schizophrenia显示文摘 | Herrmann MJ Ellgring H Fallgatter AJ | 2004 | Psychiatry Res2004，161，2： | 1 |
| 5 | Early-stage face processing dysfunction in patients with schizophrenia显示文摘 | Herrmann MJ Ellgring H Fallgatter AJ | 2004 | Psychiatry2004，161，3： | 1 |
| 6 | Myocardial bridging显示文摘 | Jorge R Herrmann AJ David R | 2005 | Eur Heart J2005，26，： | 1 |
| 7 | Far field potentials from brain stem after transcutaneous vagus nerve stimulation显示文摘 | Fallgatter AJ Neuhauser B Herrmann MJ | 2003 | J Neural Transm2003，10，12： | 1 |
| 8 | Early-stage face processing dysfunction in patients with schizophrenia显示文摘 | Herrmann MJ Ellgring H Fallgatter AJ | | 0，，： | 1 |
| 9 | Electrophysiological measurements of anterior cingulate function显示文摘 | Bartsch AJ Herrmann MJ | 2002 | J Neural Transm2002，109，56： | 1 |
| 10 | Management of stones in calyceal diverticulum显示文摘 | Gross AJ Herrmann TR | 2007 | Curr Opin Tirol2007，，02： | 1 |
| 11 | Electrophysiological measurements of anterior cingulate function 显示文摘 | Fallgatter AJ Bartsch AJ Herrmann MJ | 2002 | Journal of Neural Transmission2002，109，56： | 1 |
| 12 | Bilaterally Reduced Frontal Activation During a Verbal Fluency Task in Depressed patients as measured by near-infrared spectrscopy显示文摘 | A-C Ehlis AJ Fallgatter | 2004 | The Journal of nuropsychialry and Clinical Neurosciences2004，16，2： | 1 |
| 13 | Frontal activation during averbal-fluency task as measured by near-infrared spectroscopy 显示文摘 | Herrmann MJ Ehlis AC’Fallgatter AJ | 2003 | Brain Res Bull2003，61，1： | 1 |
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