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| 1 | Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups显示文摘AIM:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White participants.METHODS:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA levels.Additionally,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the stool.We used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all samples.RESULTS:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic groups.We also found that participant microbial profiles differed by racial/ethnic group.African Americans had significantly more Firmicutes than Whites,with enriched Ruminococcaceae.The Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of butyrate.We also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in stool.CONCLUSION:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions. | Christina M Hester Venkatakrishna R Jala Morgan GI Langille Shahid Umar K Allen Greiner Bodduluri Haribabu | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 2 | The mode of vasoinhibitory action of a pyridazinone derivative (MCI-154),a new cardiotonic agent,on contractile responses induced by alpha-adrenoceptor agonists and ^45Ca influx in isolated vascular smooth muscles显示文摘 | Shibata S Satake N Hester RK Kurahashi K Ito M | 1988 | Eur J Pharmacol1988，145，2： | 1 |
| 3 | Perceived external prestige and internal respect: new insights into the organizational identification process显示文摘 | Fuller J B Hester K | 2006 | Human Relations2006，59，6： | 1 |
| 4 | Gas hydrate measurements at Hydrate Ridge using Raman spectroscopy显示文摘 | HESTER K C DUNK R M WHITE S N | 2007 | Geochimica et Cosmochimica Acta2007，71，： | 1 |
| 5 | An Exploratory Examination of Voice Behavior from an Impression Man- agement Perspective 显示文摘 | Fuller J B Barnett T Hester K Relyea C Frey L | 2007 | Journal of Managerial Issues2007，，1： | 1 |
| 6 | Inter-rater reliability of the Inter- national Cooperative Ataxia Rating Scale (ICARS) 显示文摘 | Storey E Tuck K Hester R | 2004 | Mov Dis- ord2004，19，： | 1 |
| 7 | Oral administration of the cyclooxygenase-2 (COX-2) inhibitor meloxicam blocks ovulation in non-human primates when administered to simulate emergency contraception显示文摘 | Hester K Harper M Duffy D | 2010 | Hum Reprod2010，25，2： | 1 |
| 8 | Bridge Building within the Prov- ince of Proactivity 显示文摘 | Fuller J B Marler L E Hester K | 2012 | Journal of Organizational Behavior2012，33，3： | 1 |
| 9 | Clathrate hydrates in nature显示文摘 | HESTER K C BREWER P G | 2009 | Annual Review of Marine Science2009，1，： | 1 |
| 10 | Refinement of the fundamental niche of black mangrove (Avicennia germinans) seedlings in Louisiana: Applications for restoration显示文摘 | ALLEMAN L K HESTER M W | 2011 | Wetlands Ecology Manage2011，19，： | 1 |
| 11 | Detection of clinically amelanodc malignant melanoma and assessment of its margins by in vivo confocal scanning laser microscopy 显示文摘 | Busam KJ Hester K Charles C | 2001 | Arch Dermatol2001，137，7： | 1 |
| 12 | Homing of regulatory T cells to human skin is important for the prevention of alloimmune-mediated pathology in an in vivo cellular therapy model显示文摘 | Issa F Hester J Milward K | 2012 | PLoS One2012，7，53： | 1 |
| 13 | Clathrate hydrate in na-ture显示文摘 | Hester K C Brewer P G | 2009 | Annual Rev Mar Sci2009，1，： | 1 |
| 14 | Accuracy of volumetric flow rate measurements: an in vitro study using modern ultrasound scanners 显示文摘 | Hoyt K Hester FA Bell RL | 2009 | J Ultrasound Med2009，28，： | 1 |
| 15 | Regulatory immune cells in transplantation 显示文摘 | WOOD K J BUSHELL A HESTER J | 2012 | Nat Rev Immunol2012，12，6： | 1 |
| 16 | Molecular hydrogen storage in binary THF-H2 clathrate hydrates显示文摘 | STROBEL T A TAYLOR C J HESTER K C | 2006 | The JournalofPhvsical Chemistry B2006，110，17： | 1 |
| 17 | Ramanspectroscopic measurements of synthetic gas hy-drates in the ocean显示文摘 | Hester K C White S N Peltzer E T | 2006 | Mar Chem2006，98，2： | 1 |
| 18 | In vitro biological evaluation of high molecular weight hyperbranched polyglycerols显示文摘 | Kainthan R K Hester S R Levin E | 2007 | Biomaterials2007，28，31： | 1 |
| 19 | Perceived external prestige and in- ternal respect: New insights into the organizational iden- tification process显示文摘 | Fuller J B Hester K | 2006 | Human Relations2006，59，6： | 1 |
| 20 | Detection of clinically amelanotic malignant melanoma and assessment of its margins by in vivo confocal scanning laser microscopy显示文摘 | Busam KJ Hester K Charles C | 2001 | Arch Dermatol2001，137，7： | 1 |
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