|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models显示文摘 | Meng Yu Yuhua Fu Yijian Liang Haikun Song Yao Yao Peng Wu Yuwei Yao Yuyin Pan Xue Wen Lixiang Ma Saiyin Hexige Yu Ding Shouqing Luo Boxun Lu | 2017 | Cell Research2017，27，12： | 5 |
| 2 | Gedunin Degrades Aggregates of Mutant Huntingtin Protein and Intranuclear Inclusions via the Proteasomal Pathway in Neurons and Fibroblasts from Patients with Huntington’s Disease显示文摘Huntington's disease(HD) is a deadly neurodegenerative disease with abnormal expansion of CAG repeats in the huntingtin gene. Mutant Huntingtin protein(m HTT) forms abnormal aggregates and intranuclear inclusions in specific neurons, resulting in cell death. Here,we tested the ability of a natural heat-shock protein 90 inhibitor, Gedunin, to degrade transfected m HTT in Neuro-2 a cells and endogenous m HTT aggregates and intranuclear inclusions in both fibroblasts from HD patients and neurons derived from induced pluripotent stem cells from patients. Our data showed that Gedunin treatment degraded transfected m HTT in Neuro-2 a cells, endogenous m HTT aggregates and intranuclear inclusions in fibroblasts from HD patients, and in neurons derived from induced pluripotent stem cells from patients in a dose-and time-dependent manner, and its activity depended on the proteasomal pathway rather than the autophagy route. These findings also showed that although Gedunin degraded abnormal m HTT aggregates and intranuclear inclusions in cells from HD patient, it did not affect normal cells, thus providing a new perspective for using Gedunin to treat HD. | Weiqi Yang Jingmo Xie Qiang Qiang Li Li Xiang Lin Yiqing Ren Wenlei Ren Qiong Liu Guomin Zhou Wenshi Wei Hexige Saiyin Lixiang Ma | 2019 | Neuroscience Bulletin2019，35，6： | 2 |
| 3 | 显示文摘 | Hexig B Isama K Haishima Y | 2010 | J Biomater Sci Polym Ed2010，21，14： | 1 |
| 4 | SQUA-like genes in the orchid Phalaenopsis are expressed in both vegeta- tive and reproductive tissues 显示文摘 | CHEN D GUO B HEXIGE S | 2007 | Planta2007，226，： | 1 |
| 5 | Oligo-microarray analysis reveals the role of cyclophilin A in drug resistance显示文摘 | Shuai Chen Mingjun Zhang Honghui Ma Hexige Saiyin Suqin Shen Jiajie Xi Bo Wan Long Yu | 2008 | Cancer Chemotherapy and Pharmacology2008，，： | 1 |
| 6 | Generation and characterization of compositional gradient structure in the biodegradable chitosan/poly(ethylene oxide) blend显示文摘 | Osugi N Dong T Hexig B | 2007 | Journal of Applied Polymer Science2007，104，： | 1 |
| 7 | Self organization of Functional Gradient Structure in the Biodegradable Chitosan/Poly(vinyl alcohol) Blend Film显示文摘 | Hexig B Alata H lnoue Y | 2005 | J Polym SciPart B: Polym Phys2005，43，21： | 1 |
| 8 | Generation and Characterization of Compositional Gradient Structure in the Biodegradable Chitosan/Poly(ethylene oxide) Blend显示文摘 | Osugi N Dong T Hexig B | 2007 | J Appl Polym Sci2007，104，5： | 1 |
| 9 | The effect of recombinant E-eadherin substratum on the differentiation of endo- clerm-derived hepatocyte-like cells from embryonic stem cells显示文摘 | Haque A Hexig B Meng Q | 2011 | Biomaterials2011，32，8： | 1 |
| 10 | SQUA-like genes in the orchid Pha- laenopsis are expressed in both vegetative and reproductive tissues显示文摘 | Chen D H Bin G Hexige S | 2007 | Planta2007，226，： | 1 |
| 11 | SQUA-like genes in the orchid Phalaenopsis are expressed in both vegetative and reproductive tissues显示文摘 | Chen D H Guo B Hexige S Y | 2007 | Planta2007，226，： | 1 |
| 12 | Cloning and characterization of a PI-like MADS-box gene in Phaldenopsis orchid 显示文摘 | Guo B Hexige S Y Zhang T | 2007 | Journal of Biochemistry and Molecular Biology2007，40，： | 1 |
| 13 | Human liver specific transcriptional factor TCP10L binds to MAD4显示文摘 | Jiang D J Yu H X Hexige S Y | 2004 | J Biochem Mol Biol2004，37，4： | 1 |
| 14 | SQUA-like genes in the orchid Phalaenopsis are expressed in both vegetative and reproductive tissues显示文摘 | Chen D Guo B Hexige S | 2007 | Planta2007，226，2： | 1 |
| 15 | Human liver specific transcriptional factor TCP10L binds to MAD4显示文摘 | Jiang DJ Yu HX Hexige SY | 2004 | J Biochem Mol Biol2004，37，4： | 1 |
| 16 | Safety evaluation of surgical materials by cytotoxicity testing显示文摘 | Hexig B Nakaoka R Tsuchiya T | 2008 | J Artif Organs2008，11，： | 1 |
| 17 | TSSK5, a novel member of the testisspecific serine/threonine kinase family, phosphorylates CREB at Ser133, and stimulates the CRE/CREB responsive pathway 显示文摘 | CHEN X LIN G HEXIGE S | 2005 | Biochemical and Biophysical Research Communications2005，333，： | 1 |
| 18 | Safety evaluation of surgical materials by cytotoxicity testing 显示文摘 | Hexig B Nakaoka R Tsuchiya T | 2008 | J Artif Organs2008，11，4： | 1 |
| 19 | Novel biodegradable poly(buty-lene suceinate)/poly(ethylene oxide) blend film with com- positional and spherulite-size gradients显示文摘 | Hexig B Alata H | 2005 | J Polym Sci Part B: Polym Phys2005，43，： | 1 |
| 20 | Cloning and Characterization of a Pl-like MADS-box Gene in Phalae- nopsis Orchid显示文摘 | GUO B HEXIGE S ZHANG T | 2007 | Journal of Biochemistry and Molecu- lar Biology2007，40，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员