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您的检索式：作者名="Heyang Ding"
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| 1 | Virtual strain loading method for low temperature cohesive failure of asphalt binder显示文摘Cohesive failure is one of the primary reasons for low-temperature cracking in asphalt pavements.Understanding the micro-level mechanism is crucial for comprehending cohesive failure behavior.However,previous literature has not fully reported on this aspect.Moreover,there has been insufficient attention given to the correlation between macroscopic and microscopic failures.To address these issues,this study employed molecular dynamics simulation to investigate the low-temperature tensile behavior of asphalt binder.By applying virtual strain,the separation work during asphalt binder tensile failure was calculated.Additionally,a correlation between macroscopic and microscopic tensile behaviors was established.Specifically,a quadrilateral asphalt binder model was generated based on SARA fractions.By applying various combinations of virtual strain loading,the separation work at tensile failure was determined.Furthermore,the impact of strain loading combinations on separation work was analyzed.Normalization was employed to establish the correlation between macroscopic and microscopic tensile behaviors.The results indicated that thermodynamic and classical mechanical indicators validated the reliability of the tetragonal asphalt binder model.The strain loading combination consists of strain rate and loading number.All strain loading combinations exhibited the similar tensile failure characteristic.The critical separation strain was hardly influenced by strain loading combination.However,increasing strain rate significantly enhanced both the maximum traction stress and separation work of the asphalt binder.An increment in the loading number led to a decrease in separation work.The virtual strain combination of 0.5%-80 provided a more accurate representation of the actual asphalt's tensile behavior trend. | Heyang Ding Hainian Wang Ziye Ma Zhen Leng Ponan Feng Tangjie Wang Xin Qu | 2023 | Journal of Road Engineering2023，3，3： | 0 |
| 2 | Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells显示文摘Acute myeloid leukemia(AML)is a myeloid malignancy with generally high mortality.Although recent advances in AML research have revealed that circRNAs play significant roles in AML progression,our understanding of the leukemogenic mechanism of circRNAs remains very limited.In this study,increased expression of hsa_circ_0013880 was observed in bone marrow mononuclear cells(BMNCs)of AML patients.Overexpression of hsa_circ_0013880 promotes AML cell proliferation and migration and reduces cell apoptosis.Mechanistically,hsa_circ_0013880 could elevate the expression of USP32,a deubiquitinating enzyme that is highly expressed in the BMNCs of AML patients.Given the deubiquitination function of USP32,we further hypothesize that USP32 may mediate the malignant behaviors of AML cells by regulating the stability of Ras-related protein(Rap1b).At the molecular level,we find that silencing of USP32 increases ubiquitinated Rap1b.Overexpression of Rap1b restores the effects of USP32 knockdown,which further verifies our hypothesis.In addition,we propose another hypothesis that a potential regulatory network among hsa_circ_0013880,miR-148a-3p/miR-20a-5p and USP32 might exist in the development of AML,according to bioinformatics website predictions and our preliminary experimental verification.Overall,our findings will enrich the understanding of the hsa_circ_0013880/USP32/Rap1b axis in AML development,which may contribute to the development of novel therapeutic strategies for AML. | Heyang Zhang Yuan Tao Xin Ding Yue Wang Xiaoxue Wang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
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