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您的检索式：作者名="Hezhou Huang"
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| 1 | Gelcasting of alumina ceramics in the mixed acrylamide and polyacrlamide systems显示文摘 | Jingtao Ma Zhipeng Xie Hezhou Miao Yong Huang Yibing Cheng and Weiyou Yang | 2003 | Journal of the European ceramic society2003，23，： | 1 |
| 2 | Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer’s disease显示文摘Background:Building brain reserves before dementia onset could represent a promising strategy to prevent Alzheimer’s disease(AD),while how to initiate early cognitive stimulation is unclear.Given that the immature brain is more sensitive to environmental stimuli and that brain dynamics decrease with ageing,we reasoned that it would be effective to initiate cognitive stimulation against AD as early as the fetal period.Methods:After conception,maternal AD transgenic mice(3×Tg AD)were exposed to gestational environment enrichment(GEE)until the day of delivery.The cognitive capacity of the offspring was assessed by the Morris water maze and contextual fear-conditioning tests when the offspring were raised in a standard environment to 7 months of age.Western blotting,immunohistochemistry,real-time PCR,immunoprecipitation,chromatin immunoprecipitation(ChIP)assay,electrophysiology,Golgi staining,activity assays and sandwich ELISA were employed to gain insight into the mechanisms underlying the beneficial effects of GEE on embryos and 7–10-month-old adult offspring.Results:We found that GEE markedly preserved synaptic plasticity and memory capacity with amelioration of hallmark pathologies in 7–10-m-old AD offspring.The beneficial effects of GEE were accompanied by global histone hyperacetylation,including those at bdnf promoter-binding regions,with robust BDNF mRNA and protein expression in both embryo and progeny hippocampus.GEE increased insulin-like growth factor 1(IGF1)and activated its receptor(IGF1R),which phosphorylates Ca^(2+)/calmodulin-dependent kinase IV(CaMKIV)at tyrosine sites and triggers its nuclear translocation,subsequently upregulating histone acetyltransferase(HAT)and BDNF transcription.The upregulation of IGF1 mimicked the effects of GEE,while IGF1R or HAT inhibition during pregnancy abolished the GEE-induced CaMKIV-dependent histone hyperacetylation and BDNF upregulation.Conclusions:These findings suggest that activation of IGF1R/CaMKIV/HAT/BDNF signaling by gestational environment enrichment may serve as a promising strategy to delay AD progression. | Enjie Liu Qiuzhi Zhou Ao-Ji Xie Mengzhu Li Shujuan Zhang Hezhou Huang Zhenyu Liuyang Yali Wang Bingjin Liu Xiaoguang Li Dongsheng Sun Yuping Wei Xiaochuan Wang Qun Wang Dan Ke Xifei Yang Ying Yang Jian-Zhi Wang | 2019 | Translational Neurodegeneration2019，8，1： | 1 |
| 3 | TRANSIENT PHOTOLUMINESCENCE SPECTRA OF GaAs/AlGaAs QUANTUM WELLS, QUANTUM WELL WIRES, AND QUANTUM WELL BOXES显示文摘The interaction of the electrons with the phonons in GaAs/AlGaAs quantum wells,quantum well wires,and quantum well boxes has been studied by meansuring their time resolved photoluminescence(PL)spectra.In the quantum well(Q W)system,relaxation time of the electron energy of the narrower well is shorter than that of the wider well.It is attributed to the stronger interaction of the electrons with the interface mode phonons.In the Q W wires and Q W boxes,the shortening of the relaxation time is obvious.It is due to the stronger electron-phonon interaction caused by the reduction of screening effect.Our experiments also demonstrated the incident laser intensity dependence of the relaxation time. | CHENG Wenqin HUANG Yi ZHOU Junming FENG Wei WANG Hezhou SHE Weilong HUANG Xuguang LIN Weizhu YU Zhenxin XU Geng | 1990 | Chinese Physics Letters1990，7，6： | 0 |
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