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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Influence of regional pollution outflow on the concentrations of fine particulate matter and visibili- ty in the coastal area of southern China显示文摘 | Hing C C Tao W Karsterrn B | 2005 | Atmospheric Environ- ment2005，39，24： | 1 |
| 3 | Reliability of a new hand-held dynamometer in measuring shoulder range of motion and strength 显示文摘 | Cadogan A Laslett M Hing W | 2011 | Man Ther2011，16，1： | 1 |
| 4 | Interexaminer reliability of or- thopaedic special tests used in the assessment of shoulder pain 显示文摘 | Cadogan A Laslett M Hing W | 2011 | Manual Therapy2011，16，2： | 1 |
| 5 | Reliability of measuring sciat- ic and tibial nerve movement with diagnostic ultrasound during a neural mobilization technique 显示文摘 | Ellis R Hing W Dilley A | 2008 | Ultrasound Med Biol2008，34，8： | 1 |
| 6 | The effectiveness of post-operative rehabilitation following partial meniscectomy of the knee 显示文摘 | Reid D Rydwanski J Hing W | 2012 | Physical Therapy Reviews : PTR2012，17，1： | 1 |
| 7 | Theoretical transform of the gravity anomalies of two idealized bodies显示文摘 | Regan R D Hinge W L | 1978 | Geophysics1978，43，： | 1 |
| 8 | Mitochondrial depolarization accompanies cytochrome c release during apoptotsis in PC6 Cells显示文摘 | Heiskanen K M Bat M B Hing W W | 1999 | Biol Chem1999，274，9： | 1 |
| 9 | Characterization of porous hydroxyapatite显示文摘 | Hing K A Best S M Bonefield W | 1999 | J Mater Sci Mater Med1999，10，3： | 1 |
| 10 | Characterization of porous hydroxyapatite显示文摘 | Hing KA Best SM Bonfield W | 1999 | J Mater Sci Mater Med1999，10，3： | 1 |
| 11 | Hydroxyapatite and fluorapatite coatings for fixation of weight loaded implants显示文摘 | Hing K Best S Bonfield W | 1999 | J Mater Sci Mater Med1999，10，： | 1 |
| 12 | Characterization of porous hydroxyapatite显示文摘 | Hing K A Best S M Bonfield W | 1999 | J Mater Sci Mater in Med1999，10，： | 1 |
| 13 | Calculation of photon energy deposition kernels and e- lectron dose point kernels in water 显示文摘 | Mainegra - Hing E Rogers D W O Kawrakow I | 2005 | Medical Physics2005，32，3： | 1 |
| 14 | Neural mobilization: a systematic review of randomized controlled trials with an analysis of therapeutic efficacy 显示文摘 | ELLIS R F HING W A | 2008 | J Man ManipTher2008，16，1： | 1 |
| 15 | Immunomodula- tory activities of mushroom sclerotial polysaccharides 显示文摘 | Ka- Hing W Connie K M L Peter C K C | 2011 | Food Hydrocolloids2011，25，2： | 1 |
| 16 | Reliability of measuring sciatic and tibial nerve movement with diagnostic ultrasound during a neural mobi- lisation technique显示文摘 | Ellis R Hing W Dilley A | 2008 | Ultrasound Med Biol2008，34，8： | 1 |
| 17 | Characterization of porous hydroxyapatite显示文摘 | Hing K A Best S M Bonfield W | 1999 | J Mater Sci Mater in Med1999，10，： | 1 |
| 18 | Iliotibial band friction syndrome-a systematic review 显示文摘 | Ellis R Hing W Reid D | 2007 | Man Ther2007，12，3： | 1 |
| 19 | A retrospective drug utilization evaluation of vancomyein usage in paediatric patients显示文摘 | HING W C BEK S J LIN R T | 2004 | J Clin Pharm Ther2004，29，4： | 1 |
| 20 | Reliability of measuring sciat- ic and tibial nerve movement with diagnostic ultrasound during a neural mobilisation technique 显示文摘 | Ellis R Hing W Dilley A | 2008 | Ultrasound Med Biol2008，34，8： | 1 |
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