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| 1 | Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis显示文摘The 'a disintegrin and metalloprotease' (ADAM) family contributes to regulation of the cell-cell and cell-matrix interactions that are critical determinants of malignancy. To determine the relationship between metastasis and ADAM proteins, we compared the mRNA levels of ADAM9,-10,-12,-15, and-17 in sublines of an EBC-1 lung cancer cell line that were highly metastatic to either brain or bone. ADAM9 mRNA levels were significantly higher in highly brain-metastatic sublines than in the parent or highly bonemetastalic sublines. To elucidate the role ofADAM9 in brain metastasis, we stably transfected A549 and EBC-1 cells with a fulllength ADAM9 expression vector. Compared with mock-transfectants, ADAM9 overexpression resulted in increased invasive capacity | Shintani Y Higashiyama S Ohta M Hirabayashi H Yamamoto S Yoshimasu T Matsuda H Matsuura N | 2004 | 中国神经肿瘤杂志2004，2，2： | 36 |
| 2 | Heterogeneity in supraglacial debris thickness and its role in glacier mass changes of the Mount Gongga显示文摘在西藏的高原,许多冰河在他们的脱离地区有 supraglacial 碎片的广泛的封面,它由改变冰融化和集体损失的空间模式影响冰河反应到气候变化。不够的碎片厚度数据使分析地区性的碎片封面效果困难。山 Gongga 的海上的冰河被实质的减小在最近的十年在冰河区域和冰质量描绘了。从遥远地察觉到的数据估计的碎片层的热性质表明盖住碎片的冰河在这个区域,到全部的冰河区域的碎片盖子的比例从 1.74% ~ 53.0% 在上变化是主导的。用一个身体上基于的碎片封面效果评价模型,我们发现尽管 supraglacial 碎片的存在在重重地盖住碎片的冰河上有重要绝缘效果,融化在~上加速冰10.2%全部的脱离地区并且生产~的快速的消耗量25%盖住碎片的冰河,导致在盖住碎片、没有碎片的冰河之间的类似的集体损失。普遍碎片盖子也便于活跃终点区域的发展。在碎片封面效果的地区性的差别是明显的,强调为冰河质量在全世界在西藏的高原和另外的山脉改变的理解的碎片盖子的重要性。 | ZHANG Yong HIRABAYASHI Yukiko FUJITA Koji LIU Shi Yin LIU Qiao | 2016 | Science China Earth Sciences2016，59，1： | 11 |
| 3 | 乙酸丁酯反应精馏过程模拟设计(英文)显示文摘反应精馏偶合了反应和精馏两种单元操作,通过精馏促进反应,可以提高反应转化率和收率,为可逆反应的化工过程生产提供了新的设计途径。基于严格热力学分析计算,利用计算机模拟和优化手段。提出了乙酸丁酯反应精馏、分离纯化的生产流程。采用UNIQUAC方程表征乙酸-正丁醇-乙酸丁酯-水四元非理想体系的汽液平衡,首先,根据实验数据回归了热力学模型中的交互作用参数,并预测了体系中5个共沸物组成,模型的计算结果与实际数据吻合。基于平衡级模型,提出了由平衡反应器、反应精馏塔、倾析器和纯化塔构成的可行流程,对提出的设计流程进行了模拟、优化,得到了操作工艺参数。模拟结果对工业过程的设计和改造具有一定的指导意义。 | 李春山 Daisuke Hirabayashi Kenzi Suzuki | 2007 | 计算机与应用化学2007，24，12： | 3 |
| 4 | Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo显示文摘 | Masahiko Kurokawa Kazuhiko Nagasaka Tatsuji Hirabayashi Shin-ichi Uyama Hideki Sato Takashi Kageyama Shigetoshi Kadota Haruo Ohyama Toyoharu Hozumi Tsuneo Namba Kimiyasu Shiraki | 1995 | Antiviral Research1995，，1： | 3 |
| 5 | Precancerous lesions of the pancreas显示文摘 | Giuseppe Zamboni Kenichi Hirabayashi Paola Castelli Anne Marie Lennon | 2013 | Best Practice & Research Clinical Gastroenterology2013，，2： | 3 |
| 6 | Operative Results and Postoperative Progression of Ossification Among Patients With Ossification of Cervical Posterior Longitudinal Ligament显示文摘 | KIYOSHI HIRABAYASHI JUN MIYAKAWA KAZUHIKO SATOMI TETSUO MARUYAMA KOICHI WAKANO | 1981 | Spine1981，，4： | 2 |
| 7 | Development of a novel mouse model for dengue virus infection显示文摘 | An J Kimura-Kuroda J Hirabayashi Y | 1999 | Virology1999，263，1： | 2 |
| 8 | Isolation and characterization of the somatic embryogenesis receptor-like kinase gene homologue (CitSERK1) from Citrus unshiu Marc.显示文摘 | Takehiko Shimada Toshiro Hirabayashi Tomoko Endo Hiroshi Fujii Masayuki Kita Mitsuo Omura | 2004 | Scientia Horticulturae2004，，2： | 2 |
| 9 | Synchronous pancreatic solid pseudopapillary neoplasm and intraductal papillary mucinous neoplasm显示文摘Solid pseudopapillary neoplasm (SPN) is a rare and low-grade malignant pancreatic neoplasm composed of poorly cohesive monomorphic neoplastic cells forming solid and pseudopapillary structures with frequent hemorrhagic-cystic degeneration. Intraductal papillary mucinous neoplasm (IPMN) is a pancreatic exocrine tumor composed of intraductal papillary growth of mucin containing neoplastic cells in the main pancreatic duct or its major branches. In the case presented here, a 53-year-old, Japanese man was found to have multiple cystic lesions and dilatation of the main pancreatic duct in the neck of the pancreas. Histological examination revealed a main-duct and branch-duct type IPMN, of the gastric-type, involving the neck of the pancreas, associated with a 0.5 cm SPN in the caudal side of the IPMN. We diagnosed this case as synchronous SPN and IPMN. As far as we know, only one other case of synchronous SPN and IPMN has been reported. Both the present case and the previously reported case showed abnormal nuclear expression of β-catenin in SPN, whereas IPMN showed no abnormal nuclear expression. These results suggest that β-catenin abnormality is not a common pathogenetic factor of synchronous SPN and IPMN. | Kenichi Hirabayashi Giuseppe Zamboni Hiroyuki Ito Masami Ogawa Yoshiaki Kawaguchi Tomohiro Yamashita Toshio Nakagohri Naoya Nakamura | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 10 | Transplantation of embryonic stem cell-derived neural stem cells for spinal cord injury in adult mice显示文摘 | Kimura H Yoshikawa M Matsuda R Toriumi H Nishimura F Hirabayashi H Nakase H Kawaguchi S Ishizaka S Sakaki T | 2005 | Neurol Res2005，27，8： | 1 |
| 11 | Glycomics,coming of age显示文摘 | Kasai K | 2000 | Trends Glycosci Glycotech2000，，12： | 1 |
| 12 | Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells显示文摘 | Horie N Hirabayashi N Takahashi Y | 2005 | Biol Pharm Bull2005，28，4： | 1 |
| 13 | Effects of lightwand(Trachlight) compared with direct laryngoscopy on circulatory responses to tracheal intubation显示文摘 | Hirabayashi Y Hiruta M Kawakami T | 1998 | Br J Anaesth1998，81，2： | 1 |
| 14 | Isolation, characterization and molecular evolution of a novel pearl shell lectin from a marine bivalve Pteria penguin 显示文摘 | Naganuma T Ogawa T Hirabayashi J | 2006 | Mol Divers2006，10，4： | 1 |
| 15 | Port- site metastasis after CO2 pneumoperitoneum: role of adhesion molecules and prevention with antiadhesion molecules显示文摘 | Hirabayashi Y Yamaguchi K Shiraishi N | 2004 | Surg Endosc2004，18，7： | 1 |
| 16 | Developmental perspective of sensory organization on postural control 显示文摘 | Hirabayashi S Iwasaki Y | 1995 | Brain Dev1995，17，： | 1 |
| 17 | Tour construc-tion algorithm for the capacitated arc routing problem 显示文摘 | HIRABAYASHI R SARUWATARI Y NISHIDA N | 1992 | Asia-Pa-cific Journal of Operational Research1992，9，2： | 1 |
| 18 | Cyclooxygenase (COX)-2 immunoreactivity and relationship to p53 and Ki-67 expression in colorectal cancer显示文摘 | Kazuhiro Sakuma Takahiro Fujimori Kaoru Hirabayashi Akira Terano | 1999 | Journal of Gastroenterology1999，，2： | 1 |
| 19 | Screening wheat genotypes for high callus induction and regeneration capability from anther and immature embryo cultures显示文摘 | H. Machii H. Mizuno T. Hirabayashi H. Li T. Hagio | 1998 | Plant Cell Tissue and Organ Culture1998，，1： | 1 |
| 20 | Tour construction algorithm for the capacitated arc routing problem显示文摘 | Hirabayashi R Saruwatari Y Nishida N | 1992 | Asia-Pacific Journal of Operational Research1992，9，： | 1 |
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