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| 1 | Nestin:A novel angiogenesis marker and possible target for tumor angiogenesis显示文摘Abnormal vasculature,termed tumor vessels,is a hallmark of solid tumors.The degree of angiogenesis is associated with tumor aggressiveness and clinical outcome.Therefore,exact quantification of tumor vessels is useful to evaluate prognosis.Furthermore,selective detection of newly formed tumor vessels within cancer tissues using specific markers raises the possibility of molecular targeted therapy via the inhibition of tumor angiogenesis.Nestin,an intermediate filament protein,is reportedly expressed in repair processes,various neoplasms,and proliferating vascular endothelial cells.Nestin expression is detected in endothelial cells of embryonic capillaries,capillaries of the corpus luteum,which replenishes itself by angiogenesis,and proliferating endothelial progenitor cells,but not in mature endothelial cells.Therefore,expression of nestin is relatively limited to proliferating vascular endothelial cells and endothelial progenitor cells.Nestin expression is also reported in blood vessels within glioblastoma,prostate cancer,colorectal cancer,and pancreatic cancer,and its expression is more specific for newly formed blood vessels than other endothelial cell markers.Nestin-positive blood vessels form smaller vessels with high proliferation activity in tumors.Knockdown of nestin in vascular endothelial cells suppresses endothelial cell growth and tumor formation ability of pancreatic cancers in vivo.Using nestin to more accurately evaluate microvessel density in cancer specimens may be a novel prognostic indicator.Furthermore,nestin-targeted therapy may suppress tumor proliferation via inhibition of angiogenesis in numerous malignancies,including pancreatic cancer.In this review article,we focus on nestin as a novel angiogenesis marker and possible therapeutic target via inhibition of tumor angiogenesis. | Yoko Matsuda Masahito Hagio Toshiyuki Ishiwata | 2013 | World Journal of Gastroenterology2013，19，1： | 16 |
| 2 | Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats显示文摘 | K.B.M. Saiful Islam Satoru Fukiya Masahito Hagio Nobuyuki Fujii Satoshi Ishizuka Tadasuke Ooka Yoshitoshi Ogura Tetsuya Hayashi Atsushi Yokota | 2011 | Gastroenterology2011，，5： | 2 |
| 3 | Screening wheat genotypes for high callus induction and regeneration capability from anther and immature embryo cultures显示文摘 | H. Machii H. Mizuno T. Hirabayashi H. Li T. Hagio | 1998 | Plant Cell Tissue and Organ Culture1998，，1： | 1 |
| 4 | Inhibi- tion of neutrophil elastase reduces lung injury and bacterial count in Hamsters 显示文摘 | Hagio T Kishikawa K Kawabata K | 2008 | Pulm Pharmacol Ther2008，21，6： | 1 |
| 5 | Sintering and crystallization of ground hexagonal boron nitride显示文摘 | Hagio T Yoshida H | 1994 | J Mater Sci Lett1994，13，： | 1 |
| 6 | The role of neutrophil elastase in acute lung injury显示文摘 | Hagio T Matsuoka S | 2002 | Eur J Pharmacol2002，451，1： | 1 |
| 7 | Tumors are unique organs defined by abnormal signaling and context显示文摘 | Radisky D Hagios C Bissell MJ | 2001 | Semin in Cancer Biol2001，11，2： | 1 |
| 8 | Role of lymphocytes in spontaneous regression of experimentally transplanted canine transmissible venereal sarcoma显示文摘 | Mizuno S Fujinaga T Hagio M | 1994 | J Vet Med Sci1994，56，1： | 1 |
| 9 | Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters显示文摘 | Hagio T Kishikawa K Kawabata K | 2008 | Pulm Pharmacol Ther2008，21，6： | 1 |
| 10 | Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters 显示文摘 | KAWABATA K HAGIO T MATSUMOTO S | 2000 | Am J Respir Crit Care Med2000，161，6： | 1 |
| 11 | Pharmacological profile of a specific neutrophil elastase inhibitor,Sivelestat sodium hydrate显示文摘 | KAWABATA K HAGIO T MATSUOKA S | 2003 | Nippon Yakurigaku Zasshi2003，122，2： | 1 |
| 12 | The role of neutrophil elastase in acute lung injury 显示文摘 | Kawabata K Hagio T Matsuoka S | 2002 | Eur J Pharmacol2002，451，1： | 1 |
| 13 | Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters显示文摘 | Kazuhito Kawabata Tetsuya Hagio Shigeru Matsumoto | 2000 | Am J Respir Crit Care Med2000，161，6： | 1 |
| 14 | Bile Acid Analysis in Various Biological Samples using ultra Performance Liquid Chromatogra- phy/Electrospray Ionization -Mass Spectrometry 显示文摘 | Hagio M Matsumoto M Ishizuka S | 2011 | Methods in Molecular Biology2011，708，10： | 1 |
| 15 | Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster显示文摘 | Hagio T Nakao S Matsuoka H | | 0，，： | 1 |
| 16 | Bile acid is a host factor that regulates the composition of the cecal microbiota in rats显示文摘 | ISLAM K B FUKIYA S HAGIO M | 2011 | Gastroenterology2011，141，5： | 1 |
| 17 | Pharmacological profile of a specific neutrophil elastase inhibitor,Sivelestat sodiumhydrate显示文摘 | Kawabata K Hagio T Matsuoka S | 2003 | Nippon Yakurigaku Zasshi2003，122，2： | 1 |
| 18 | Sintering of the mech-anochemically activated powders of hexagonal boronnitride显示文摘 | Hagio T Kobayashi K Yoshida H | 1989 | J Am Ceram Soc1989，72，8： | 1 |
| 19 | Deayed neutrophile lastase inhibition prevents subsequent progression of acute lung in- juty induced by endotoxin inhalation in hamsters 显示文摘 | Kavabata K Hagio JM Atsumoti S | 2000 | Am J Re- spir2000，161，6： | 1 |
| 20 | The Role of Neutrophil Elastase in Acute Lung Injury显示文摘 | Kazuhito Kawabata Tetsuya Hagio Shozo Matsuoka | 2002 | Europan Journal of Pharmacology2002，451，1： | 1 |
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