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| 1 | Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial显示文摘 | Tetsuya Mitsudomi Satoshi Morita Yasushi Yatabe Shunichi Negoro Isamu Okamoto Junji Tsurutani Takashi Seto Miyako Satouchi Hirohito Tada Tomonori Hirashima Kazuhiro Asami Nobuyuki Katakami Minoru Takada Hiroshige Yoshioka Kazuhiko Shibata Shinzoh Kudoh Ei | 2010 | Lancet Oncology2010，，2： | 8 |
| 2 | New model for cardiomyocyte sheet transplantation using a virus-cell fusion technique显示文摘AIM: To facilitate close contacts between transplanted cardiomyocytes and host skeletal muscle using cell fusion mediated by hemagglutinating virus of Japan envelope(HVJ-E) and tissue maceration. METHODS: Cardiomyocytes(1.5 × 106) from fetal rats were first cultured. After proliferation, some cells were used for fusion with adult muscle fibers using HVJ-E. Other cells were used to create cardiomyocyte sheets(area: about 3.5 cm2 including 2.1 × 106 cells), which were then treated with Nile blue, separated, and transplanted between the latissimus dorsi and intercostal muscles of adult rats with four combinations of HVJ-E and/or Na OH maceration: G1: HVJ-E(+), Na OH(+), Cardiomyocytes(+); G2: HVJ-E(-), NaO H(+), Cardiomyocytes(+); G3: HVJ-E(+),Na OH(-), Cardiomyocytes(+); G4: HVJ-E(-), Na OH(-), Cardiomyocytes(-). At 1 and 2 wk after transplantation, the four groups were compared by detection of beating domains, motion images using moving target analysis software, action potentials, gene expression of MLC-2v and Mesp1 by reverse transcription-polymerase chain reaction, hematoxylin-eosin staining, and immunostaining for cardiac troponin and skeletal myosin.RESULTS: In vitro cardiomyocytes were fused with skeletal muscle fibers using HVJ-E. Cardiomyocyte sheets remained in the primary transplanted sites for 2 wk. Although beating domains were detected in G1, G2, and G3 rats, G1 rats prevailed in the number, size, motion image amplitudes, and action potential compared with G2 and G3 rats. Close contacts were only found in G1 rats. At 1 wk after transplantation, the cardiomyocyte sheets showed adhesion at various points to the myoblast layer in the latissimus dorsi muscle. At 2 wk after transplantation, close contacts were seen over a broad area. Part of the skeletal muscle sarcoplasma seemed to project into the myocardiocyte plasma and some nuclei appeared to share both sarcoplasmas.CONCLUSION: The present results show that close contacts were acquired and facilitated the beating function, thereby providing a new cellular transplantation method using HVJ-E and NaO H maceration. | Yuto Takahashi Daihachiro Tomotsune Sakiko Takizawa Fengming Yue Mika Nagai Tadayuki Yokoyama Kanji Hirashima Katsunori Sasaki | 2015 | World Journal of Stem Cells2015，7，5： | 3 |
| 3 | The relationship between tyrosine kinase inhibitor therapy and overall survival in patients with non-small cell lung cancer carrying EGFR mutations显示文摘For patients with epidermal growth factor receptor (EGFR) mutation-positive lung cancer, the relationship between the dose or duration of treatment with tyrosine kinase inhibitor (TKI) and overall survival remains unclear. Here, we analyzed clinical data of 39 patients who were diagnosed with EGFR mutation-positive non-small cell lung cancer and treated with TKI, but subsequently died. Several parameters were measured in this study: overall survival; first, second, and overall TKI therapy durations; first TKI intensity (actual dose/normal dose); and TKI rate (overall TKI therapy duration/overall survival). The response rate to TKI therapy was 50% , and the median survival was 553 days. After TKI therapy failed, 38.5% patients were re-challenged with TKI. We observed a moderate relationship [r = 0.534, 95% confidential interval (CI) = 0.263 to 0.727, P < 0.001] between overall TKI therapy duration and overall survival. However, we found no relationship between overall survival and first TKI intensity (r = 0.073, 95% CI = -0.380 to 0.247, P = 0.657) or TKI rate (r = 0.0345, 95% CI = -0.284 to 0.346, P = 0.835). Nonsmall cell lung cancer patients with mutation-positive tumors remained on TKI therapy for, on average, 33% of the overall survival time. These findings suggest that patients with EGFR mutation-positive tumors should not stick to using TKIs. | Hidekazu Suzuki Tomonori Hirashima Norio Okamoto Tadahiro Yamadori Motohiro Tamiya Naoko Morishita Takayuki Shiroyama Tomoyuki Otsuka Kanako Kitai Ichiro Kawase | 2013 | Chinese Journal of Cancer2013，32，3： | 3 |
| 4 | Measurement of basilar artery bending and elongation by magnetic resonance cerebral angiography显示文摘 | Manabu Nishikata Yutaka Hirashima Takahiro Tomita Ryusuke Futatsuya Yukio Horie Shunro Endo | 2003 | Archives of Gerontology and Geriatrics2003，，3： | 2 |
| 5 | Safe and effective sedation in endoscopic submucosal dissection for early gastric cancer: a randomized comparison between propofol continuous infusion and intermittent midazolam injection显示文摘 | Shinsuke Kiriyama Takuji Gotoda Hiromi Sano Ichiro Oda Fumiya Nishimoto Tetsuro Hirashima Chika Kusano Hiroyuki Kuwano | 2010 | Journal of Gastroenterology2010，，8： | 2 |
| 6 | Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors显示文摘 | ITOH H HIRASHIMA M | 2000 | Nature2000，408，6808： | 1 |
| 7 | 显示文摘 | Shimizu K Imai H Hirashima H | 1999 | Thin Solid Films1999，351，12： | 1 |
| 8 | Phase ]I trial of paclitaxel and nedaplatin in patients with advanced/recurrent uterine cervical cancer: a Kansai Clinical Oncology Group study 显示文摘 | Takekuma M Hirashima Y Ito K | 2012 | Gynecol Oncol2012，126，3： | 1 |
| 9 | Independent predic-tors of recurrence of subdural hematoma:results of multivariateanalysis performed using a logistic regressionmodel显示文摘 | Yamamoto H Hirashima Y Hamada H | 2003 | J Neuro-surg2003，98，6： | 1 |
| 10 | PhaseⅢstudy comparing the effects of carboplatin plus S-1 and carboplatin plus paclitaxel in chemotherapy-naive patients with advanced non-small cell lung cancer:An updated report of the LETS study(WJTOG3605)显示文摘 | Hirashima T Okamoto I Yoshioka H | 2011 | J Clin Oncol2011，，： | 1 |
| 11 | The ratio of neutrophils to lymphocytes and the phenotypes of neutrophils in patients with early gastric cancer显示文摘 | Hirashima M Higuchi S Sakamoto K | | 0，，06： | 1 |
| 12 | Impact of insulin- like growth factor type 1 receptor, epidermal growth factor recep- tor, and HER2 expressions on outcomes of patients with gastric cancer显示文摘 | Matsubara ] Yamada Y Hirashima Y | 2008 | Clin Cancer Res2008，14，10： | 1 |
| 13 | Prognostic significance of telomeric repeat length alterations in pathological stage I-IIIa non-small cell lung cancer显示文摘 | Komiya T Nitta T | 2000 | Anticancer Res2000，20，： | 1 |
| 14 | Relationships between diet control and the development of spontaneous type Ⅱ diabetes and diabetic nephropathy in OLETF rats显示文摘 | Mori S Kawano K Hirashima T | 1996 | Diabetes Res Clin Pract1996，33，： | 1 |
| 15 | Biosurfactants of MEL-a increase gene transfectionmediated by cationic liposomes显示文摘 | Inoh Y Kitamoto D Hirashima N | 2001 | Biochem Biophys Res Commun2001，289，1： | 1 |
| 16 | Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina:possible role of reactive oxygen species显示文摘 | HIRASHIMA O KAWANO H MOTOYAMA T | 2000 | J Am Coll Cardiol2000，35，7： | 1 |
| 17 | Flkl-positive cells derived from embryonic stem cells serve as vascular progenitors显示文摘 | Yamashita J hoh H Hirashima M | 2000 | Nature2000，408，6808： | 1 |
| 18 | Clinical effect of recombinant human granulocyte colony-stimulating factor(rhG-CSF) on various types of neutropenia including cyclicneutropenia 显示文摘 | Hirashima K Yoshida Y Asano S | 1991 | Biotherapy1991，3，4： | 1 |
| 19 | Independent predictors of recur rence of chronic subdural hematoma: results of multiva- riate analysis performed using a logistic regression model显示文摘 | Yamamoto H Hirashima Y Hamada H Hayashi N Origasa H Endo S | 2003 | J Neurosurg2003，98，： | 1 |
| 20 | A modified version of galectin-9 sup-presses cell growth and induces apoptosisof human T-cell leukemia virus type I-in-fected T-cell lines 显示文摘 | Okudaira T Hirashima M Ishikawa C etal | 2007 | Int J Cancer2007，120，10： | 1 |
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