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| 1 | Tubulopapillary adenoma of the gallbladder accompanied by bile duct tumor thrombus显示文摘Intraductal papillary mucinous neoplasm of the bile duct(IPNB)is recognized as a precancerous lesion;however,both its pathogenesis and progression remain unclear.We present here a case of IPNB arising from the gallbladder accompanied by bile duct tumor thrombus in a 79-year-old female.The resected specimen revealed a tubulopapillary adenoma with no malignant cells.This case suggests that even in the absence of malignant cells,these tumors can behave as malignant tumors requiring aggressive treatment.Even if no malignant cells are present,intraepithelial neoplasms occurring in the ampullopancreatobiliary tract can behave as malignant tumors. | Kentaroh Yamamoto Fumio Yamamoto Atsuhiro Maeda Hirotsune Igimi Mami Yamamoto Ryosuke Yamaguchi Yuichi Yamashita | 2014 | World Journal of Gastroenterology2014，20，26： | 3 |
| 2 | An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene显示文摘 | Hirotsune S Yoshida N Chen A 2003 | 2003 | Nature2003，423，： | 1 |
| 3 | Postoperative extradural hematoma after removal of a subgaleal drainage catheter显示文摘 | Meguro T Terada K Hirotsune N | 2007 | Neurol Med Clair2007，47，7： | 1 |
| 4 | An expressed pseudogene regulates mRNA stability of its homologous coding gene显示文摘 | HIROTSUNE S | 2003 | Tanpakushitsu Kakusan Koso2003，48，14： | 1 |
| 5 | Graded reduction of Pafahlbl (L IS1) activity results in neuronal migration defects and early embryonic lethality 显示文摘 | Hirotsune S Fleck MW Gambello MJ | 1998 | Nat Genet1998，19，： | 1 |
| 6 | An expressed pesudogene regulates the messenger-RNA stability of its homologous codinggene 显示文摘 | Hirotsune S Yoshida N Chen A | 2003 | Nature2003，423，6935： | 1 |
| 7 | Hippocampal abnormalities and enhanced excitability in a murine model of human lissenecphaly 显示文摘 | Fleck M W Hirotsune S Gambello M J | 2000 | J Neurosci2000，20，： | 1 |
| 8 | Pathological and physiological functional cross-talks ofα-synuclein and tau in the central nervous system显示文摘α-Synuclein and tau are abundant multifunctional brain proteins that are mainly expressed in the presynaptic and axonal compartments of neurons,respectively.Previous works have revealed that intracellular deposition ofα-synuclein and/or tau causes many neurodegenerative disorders,including Alzheimer’s disease and Parkinson’s disease.Despite intense investigation,the normal physiological functions and roles ofα-synuclein and tau are still unclear,owing to the fact that mice with knockout of either of these proteins do not present apparent phenotypes.Interestingly,the co-occurrence ofα-synuclein and tau aggregates was found in post-mortem brains with synucleinopathies and tauopathies,some of which share similarities in clinical manifestations.Furthermore,the direct interaction ofα-synuclein with tau is considered to promote the fibrillization of each of the proteins in vitro and in vivo.On the other hand,our recent findings have revealed thatα-synuclein and tau are cooperatively involved in brain development in a stage-dependent manner.These findings indicate strong cross-talk between the two proteins in physiology and pathology.In this review,we provide a summary of the recent findings on the functional roles ofα-synuclein and tau in the physiological conditions and pathogenesis of neurodegenerative diseases.A deep understanding of the interplay betweenα-synuclein and tau in physiological and pathological conditions might provide novel targets for clinical diagnosis and therapeutic strategies to treat neurodegenerative diseases. | Mingyue Jin Shengming Wang Xiaodie Gao Zhenyou Zou Shinji Hirotsune Liyuan Sun | 2024 | Neural Regeneration Research2024，19，4： | 1 |
| 9 | Hippocampal abnor- malities and enhanced excitability in a murine model of human l issen- cephaly 显示文摘 | Fleck MW Hirotsune S Gambello M J | 2000 | J Neurosci2000，20，7： | 1 |
| 10 | An expressed pseudogene regulatese the messenger-RNA stability of its homologous coding gene显示文摘 | Hirotsune S Yoshida N Chen A | 2003 | Nature2003，423，： | 1 |
| 11 | An expressed pseudogene regulates the messenger-RNA stability of its homologous cod ing gene显示文摘 | HIROTSUNE S YOSHIDA N CHEN A | 2003 | Nature2003，423，6935： | 1 |
| 12 | Acceleration of cell growth and ester formation by ultrasonic by ultrasonic wave irradiation显示文摘 | Matsuura K Hirotsune M Nunokawa Y | 1994 | J Ferment Bioeng1994，71，1： | 1 |
| 13 | Acceleration of cell growth and ester formation by ultrasonic wave irradiation 显示文摘 | Matsuura K Hirotsune M Nunokawa Y | 1994 | J Fermentation Bioeng1994，77，1： | 1 |
| 14 | An expressed pseudo- gene regulates the messenger-RNA stability of its homologous coding gene 显示文摘 | Hirotsune S Yoshida N Chen A | 2003 | Nature2003，423，6935： | 1 |
| 15 | Restriction landmark genomie scanning method and its various applications显示文摘 | Hayashizaki Y Hirotsune S Okazaki Y | 1993 | Eleetrophoresis1993，14，： | 1 |
| 16 | Early treatment of subarachnoid hemorrhage after preventing rerupture of an aneurysm 显示文摘 | Kinugasa K Kamata I Hirotsune N | 1995 | J Neurosurg1995，83，1： | 1 |
| 17 | A genomic scanning method for higherorganisms using restriction sites as landmarks显示文摘 | Hatada I Hayashizaki Y Hirotsune S Komatsubara H Mukai T | 1991 | Proc Natl Acad Sci USA1991，88，： | 1 |
| 18 | Acceleration of cell growth and ester formation by ultrasonic wave irradiation 显示文摘 | Matsuura K Hirotsune M Nunokawa Y | 1994 | Journal of Fermentation and Bioengineering1994，77，1： | 1 |
| 19 | Acceleration of cell growth and ester formation by ultrasonic wave irradiation 显示文摘 | Matsuura K Hirotsune M Nunokawa Y | 1994 | Journal of Fermentation and Bioengineering1994，77，1： | 1 |
| 20 | Long-term follow-up study of patients with unilateral moyamoya disease显示文摘 | Hirotsune N Meguro T Kawada S | | 0，，2： | 1 |
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