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| 1 | New Technologies and Systems for High Quality Citrus Fruit Production, Labor-saving and Orchard Construction in Mountain Areas of Japan显示文摘Novel technologies have been necessary for improving fruit quality and productivity of citrus, labor-saving and orchard conservation on steep slope lands since aging of growers and decrease in the number of successors is remarkable in mountain areas of southwestern Japan. The purpose of this paper is to introduce new technologies for improving citrus production that have been developed in recent years. A new fruit quality control system using drip irrigation and liquid fertilization technique combined with year-round plastic mulching was developed, and it enables high quality and stable citrus fruit production. Water and/or nutrient solution is automatically supplied through drip tubes that are laid under the mulching sheets to give adequate water stress, so as to improve sugar and acid content of fruit. A new transportation system for steep sloping citrus orchards, which is a combination of the monorail system and contour narrow paths, was suggested. A small walking cultivator was developed to explain the procedure of narrow path excavation. After introducing the narrow path, working hours for fertilizer and chemical herbicide application were reduced. Disaster prevention mapping of citrus orchards on slope lands was developed based on computer-aided seepage estimation and topographic data. The mapping can show zones of both ascending flow and descending flow of underground water during heavy rains in citrus orchards. The mapping is considered to be effective for the management of orchards and prevention of erosion on slope lands. | Kunihisa MORINAGA Osamu SUMIKAWA Osamu KAWAMOTO Hiroyasu YOSHIKAWA Seiji NAKAO Masahiko SHIMAZAKI Shin-no-suke KUSABA Norihiro HOSHI | 2005 | Journal of Mountain Science2005，2，1： | 21 |
| 2 | Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells显示文摘Enzymes 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 and-4(PFKFB-3 and PFKFB-4)play a significant role in the regulation of glycolysis in cancer cells as well as its proliferation and survival.The expression of these mRNAs is increased in malignant tumors and strongly induced in different cancer cell lines by hypoxia inducible factor(HIF)through active HIF binding sites in promoter region of PFKFB-4 and PFKFB-3 genes.Moreover,the expression and hypoxia responsibility of PFKFB-4 and PFKFB-3 was also shown for pancreatic(Panc1,PSN-1,and MIA PaCa-2)as well as gastric(MKN45 and NUGC3)cancer cells.At the same time,their basal expression level and hypoxia responsiveness vary in the different cells studied:the highest level of PFKFB-4 protein expression was found in NUGC3 gastric cancer cell line and lowest in Panc1 cells,with a stronger response to hypoxia in the pancreatic cancer cell line.Overexpression of different PFKFB in pancreatic and gastric cancer cells under hypoxic condition is correlated with enhanced expression of vascular endothelial growth factor(VEGF)and Glut1 mRNA as well as with increased level of HIF-1αprotein.Increased expression of different PFKFB genes was also demonstrated in gastric,lung,breast,and colon cancers as compared to corresponding nonmalignant tissue counterparts from the same patients,being more robust in the breast and lung tumors.Moreover,induction of PFKFB-4 mRNA expression in the breast and lung cancers is stronger than PFKFB-3mRNA.The levels of both PFKFB-4 and PFKFB-3 proteins in non-malignant gastric and colon tissues were more pronounced than in the non-malignant breast and lung tissues.It is interesting to note that Panc1and PSN-1 cells transfected with dominant/negative PFKFB-3(dnPFKFB-3)showed a lower level of endogenous PFKFB-3,PFKFB-4,and VEGF mRNA expressions as well as a decreased proliferation rate of these cells.Moreover,a similar effect had dnPFKFB-4.In conclusion,there is strong evidence that PFKFB-4 and PFKFB-3 isoenzymes are induced under hypoxia in pancreatic and other cancer cell lines,are overexpressed in gastric,colon,lung,and breast malignant tumors and undergo changes in their metabolism that contribute to the proliferation and survival of cancer cells.Thus,targeting these PFKFB may therefore present new therapeutic opportunities. | Oleksandr H Minchenko Katsuya Tsuchihara Dmytro O Minchenko Andreas Bikfalvi Hiroyasu Esumi | 2014 | World Journal of Gastroenterology2014，20，38： | 17 |
| 3 | Noninvasive assessment of liver fibrosis in patients with chronic hepatitis B显示文摘Infection with hepatitis B virus is an important healthproblem worldwide:it affects more than 350 millionpeople and is a leading cause of liver-related morbidity,accounting for 1 million deaths annually.Hepatic fibrosis is a consequence of the accumulation of extracellular matrix components in the liver.An accurate diagnosis of liver fibrosis is essential for the management of chronic liver disease.Liver biopsy has been considered the gold standard for diagnosing disease,grading necroinflammatory activity,and staging fibrosis.However,liver biopsy is unsuitable for repeated evaluations because it is invasive and can cause major complications,including death.Several noninvasive evaluations have been introduced for the assessment of liver fibrosis:serum biomarkers,combined indices or scores,and imaging techniques including transient elastography,acoustic radiation force impulse,real-time tissue elastography,and magnetic resonance elastography.Here,we review the recent progress of noninvasive assessment of liver fibrosis in patients with chronic hepatitis B.Most noninvasive evaluations for liver fibrosis have been validated first in patients with chronic hepatitis C,and later in those with chronic hepatitis B.The establishment of a noninvasive assessment of liver fibrosis is urgently needed to aid in the management of this leading cause of chronic liver disease. | Masaru Enomoto Hiroyasu Morikawa Akihiro Tamori Norifumi Kawada | 2014 | World Journal of Gastroenterology2014，20，34： | 16 |
| 4 | Feasibility of cold snare polypectomy in Japan: A pilot study显示文摘AIM: To investigate the feasibility of cold snare polypectomy(CSP) in Japan.METHODS: The outcomes of 234 non-pedunculated polyps smaller than 10 mm in 61 patients who underwent CSP in a Japanese referral center were retrospectively analyzed. The cold snare polypectomies were performed by nine endoscopists with no prior experience in CSP using an electrosurgical snare without electrocautery.RESULTS: CSPs were completed for 232 of the 234 polyps. Two(0.9%) polyps could not be removed without electrocautery. Immediate postpolypectomy bleeding requiring endoscopic hemostasis occurred in eight lesions(3.4%; 95%CI: 1.1%-5.8%), but all were easily managed. The incidence of immediate bleeding after CSP for small polyps(6-9 mm) was significantly higher than that of diminutive polyps(≤ 5 mm; 15% vs 1%, respectively). Three(5%) patients complained of minor bleeding after the procedure but required no intervention. The incidence of delayed bleeding requiringendoscopic intervention was 0.0%(95%CI: 0.0%-1.7%). In total, 12% of the resected lesions could not be retrieved for pathological examination. Tumor involvement in the lateral margin could not be histologically assessed in 70(40%) lesions.CONCLUSION: CSP is feasible in Japan. However, immediate bleeding, retrieval failure and uncertain assessment of the lateral tumor margin should not be underestimated. Careful endoscopic diagnosis before and evaluation of the tumor residue after CSP are recommended when implementing CSP in Japan. | Yoji Takeuchi Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Kengo Nagai Fumi Matsui Tomofumi Akasaka Noboru Hanaoka Koji Higashino Hiroyasu Iishi Ryu Ishihara Henrik Thorlacius Noriya Uedo | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，17： | 14 |
| 5 | 用ORP作为氧化沟同步硝化反硝化控制参数显示文摘同步硝化反硝化(simultaneous nitrification and denitrification,简称SND)是氧化沟工艺实现优良脱氮效果的主要原因,为了较好实现SND,采用ORP作为氧化沟工艺SND的控制参数.采用缺氧-厌氧-氧化沟模型对市政污水进行了生物脱氮研究.UORP在-30~30mV,NH4^+和NO3^-的含量均比较低,发生了较好的SND;UORP在30mV以上,出水的总无机氮(TIN)中95%以上为NO3^-,该状况下硝化效果良好,UORP在-30mV以下,硝化不充分,出水的TIN中78%以上为NH4^+;UORP在-30~30mV,TN的去除率在88%以上,SND作用去除的NO3^-占总的NO3^-去除的99%以上;氧化沟中的NH4^+和NO3^-之比的对数与UORP有着很好的相关性,相关系数R=-0.97. | 侯红勋 陈伦强 王淑莹 Takashi Mino Hiroyasu Satoh | 2006 | 北京工业大学学报2006，32，12： | 13 |
| 6 | Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice显示文摘AIM:To investigate the causal relationship between hypoadiponectinemia and colorectal carcinogenesis in in vivo experimental model,and to determine the con-tribution of adiponectin defi ciency to colorectal cancer development and proliferation.METHODS:We examined the influence of adiponectin defi ciency on colorectal carcinogenesis induced by the administration of azoxymethane(AOM)(7.5 mg/kg,in-traperitoneal injection once a week for 8 wk),by using adiponectin-knockout(KO) mice.RESULTS:At 53 wk after the fi rst AOM treatment,KOmice developed larger and histologically more progres-sive colorectal tumors with greater frequency com-pared with wild-type(WT) mice,although the tumor incidence was not different between WT and KO mice.KO mice showed increased cell proliferation of colorec-tal tumor cells,which correlated with the expression levels of cyclooxygenase-2(COX-2) in the colorectal tumors.In addition,KO mice showed higher incidence and frequency of liver tumors after AOM treatment.Thirteen percent of WT mice developed liver tumors,and these WT mice had only a single tumor.In contrast,50% of KO mice developed liver tumors,and 58% of these KO mice had multiple tumors.CONCLUSION:Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by AOM in mice.This study strongly suggests that hypoadiponectinemia could be involved in the pathogenesis for colorectal cancer and liver tumor in human subjects. | Tamao Nishihara Miyako Baba Morihiro Matsuda Masahiro Inoue Yasuko Nishizawa Atsunori Fukuhara Hiroshi Araki Shinji Kihara Tohru Funahashi Shinji Tamura Norio Hayashi Hiroyasu Iishi Iichiro Shimomura | 2008 | World Journal of Gastroenterology2008，14，42： | 12 |
| 7 | Radiofrequency ablation as treatment for pulmonary metastasis of colorectal cancer显示文摘Radiofrequency ablation(RFA)causes focal coagulation necrosis in tissue.Its first clinical application was reported in 2000,and RFA has since been commonly used in both primary and metastatic lung cancer.The procedure is typically performed using computed tomography guidance,and the techniques for introducing the electrode to the tumor are simple and resemble those used in percutaneous lung biopsy.The most common complication is pneumothorax,which occurs in up to 50%of procedures;chest tube placement for pneumothorax is required in up to 25%of procedures.Other severe complications,such as pleural effusion requiring chest tube placement,infection,and nerve injury,are rare.The local efficacy depends on tumor size,and local progression after RFA is not rare,occurring in 10%or more of patients.The local progression rate is particularly high for tumors>3 cm.Repeat RFA may be used to treat local progression.Short-to mid-term survival after RFA appears promising and is approximately 85%-95%at 1 year and 45%-55% at 3 years.Long-term survival data are sparse.Better survival may be expected for patients with small metastasis,low carcinoembryonic antigen levels,and/or no extrapulmonary metastasis.The notable advantages of RFA are that it is simple and minimally invasive;preserves pulmonary function;can be repeated;and is applicable regardless of previous treatments.Its most substantial limitation is limited local efficacy.Although surgery is still the method of choice for treatment with curative intent,the ultimate application of RFA may be to replace metastasectomy for small metastases.Randomized trials comparing RFA with surgery are needed. | Takao Hiraki Hideo Gobara Toshihiro Iguchi Hiroyasu Fujiwara Yusuke Matsui Susumu Kanazawa | 2014 | World Journal of Gastroenterology2014，20，4： | 12 |
| 8 | Nutritional status in relation to lifestyle in patients with compensated viral cirrhosis显示文摘AIM:To assess the nourishment status and lifestyle of non-hospitalized patients with compensated cirrhosis by using noninvasive methods.METHODS:The subjects for this study consisted of 27 healthy volunteers,59 patients with chronic viral hepatitis,and 74 patients with viral cirrhosis,from urban areas.We assessed the biochemical blood tests,anthropometric parameters,diet,lifestyle and physical activity of the patients.A homeostasis model assessment-insulin resistance(HOMA-IR) value of ≥ 2.5 was considered to indicate insulin resistance.We measured height,weight,waist circumference,arm circumference,triceps skin-fold thickness,and handgrip strength,and calculated body mass index,arm muscle circumference(AMC),and arm muscle area(AMA).We interviewed the subjects about their dietary habits and lifestyle using health assessment computer software.We surveyed daily physical activity using a pedometer.Univariate and multivariate logistic regression modeling were used to identify the relevant factors for insulin resistance.RESULTS:The rate of patients with HOMA-IR ≥ 2.5(which was considered to indicate insulin resistance) was 14(35.9%) in the chronic hepatitis and 17(37.8%) in the cirrhotic patients.AMC(%)(control vs chronic hepatitis,111.9% ± 10.5% vs 104.9% ± 10.7%,P = 0.021;control vs cirrhosis,111.9% ± 10.5% vs 102.7% ± 10.8%,P = 0.001) and AMA(%)(control vs chronic hepatitis,128.2% ± 25.1% vs 112.2% ± 22.9%,P = 0.013;control vs cirrhosis,128.2% ± 25.1% vs 107.5% ± 22.5%,P = 0.001) in patients with chronic hepatitis and liver cirrhosis were significantly lower than in the control subjects.Handgrip strength(%) in the cirrhosis group was significantly lower than in the controls(control vs cirrhosis,92.1% ± 16.2% vs 66.9% ± 17.6%,P < 0.001).The results might reflect a decrease in muscle mass.The total nutrition intake and amounts of carbohydrates,protein and fat were not significantly different amongst the groups.Physical activity levels(kcal/d)(control vs cirrhosis,210 ± 113 kcal/d vs 125 ± 74 kcal/d,P = 0.001),number of steps(step/d)(control vs cirrhosis,8070 ±3027 step/d vs 5789 ± 3368 step/d,P = 0.011),and exercise(Ex)(Ex/wk)(control vs cirrhosis,12.4 ± 9.3 Ex/wk vs 7.0 ± 7.7 Ex/wk,P = 0.013) in the cirrhosis group was significantly lower than the control group.The results indicate that the physical activity level of the chronic hepatitis and cirrhosis groups were low.Univariate and multivariate logistic regression modeling suggested that Ex was associated with insulin resistance(odds ratio,6.809;95% CI,1.288-36.001;P = 0.024).The results seem to point towards decreased physical activity being a relevant factor for insulin resistance.CONCLUSION:Non-hospitalized cirrhotic patients may need to maintain an adequate dietary intake and receive lifestyle guidance to increase their physical activity levels. | Fumikazu Hayashi Chika Momoki Miho Yuikawa Yuko Simotani Etsushi Kawamura Atsushi Hagihara Hideki Fujii Sawako Kobayashi Shuji Iwai Hiroyasu Morikawa Masaru Enomoto Akihiro Tamori Norifumi Kawada Satoko Ohfuji Wakaba Fukusima Daiki Habu | 2012 | World Journal of Gastroenterology2012，18，40： | 11 |
| 9 | Elevation of the glycated albumin to glycated hemoglobin ratio during the progression of hepatitis C virus related liver fibrosis显示文摘AIM: To analyze the relationship between the glycated albumin (GA) to glycated hemoglobin (HbA1c) ratio and the histological grading of liver fibrosis.METHODS: The study retrospectively included consecutive hepatitis C virus positive chronic liver disease patients (n = 142) who had undergone percutaneous liver biopsy between January 2008 and March 2010 at our institution. The ratios of GA/HbA1c were calculated in all patients to investigate the relationship with the degree of the liver fibrosis. The values of the aspartate aminotransferase-to-platelet ratio index (APRI), an excellent marker for the evaluation of liver fibrosis, were also calculated. In addition, we combined the ratio of GA/HbA1c and the APRI in order to improve our ability to detect the presence of significant liver fibrosis. RESULTS: Sixty-one (43%) patients had either no fibrosis or minimal fibrosis (METAVIR score: F0-F1), while 25 (17%) had intermediate fibrosis (F2). Fifty-six (39%) patients had severe fibrosis (F3-F4) and 27 of them had cirrhosis (F4). The mean values of the GA/HbA1c increased with the progression of the fibrosis (F0-1: 2.83 ± 0.24, F2: 2.85 ± 0.24, F3: 2.92 ± 0.35, F4: 3.14 ± 0.54). There was a significant dif- ference between the F0-F1 vs F4, F2 vs F4, and F3 vs F4 groups (P < 0.01, P < 0.01, P < 0.01 and P < 0.05, respectively). The GA/HbA1c ratio was significantly higher in the patients with cirrhosis (F4) than in those without cirrhosis (F0-F3) (3.14 ± 0.54 vs 2.85 ± 0.28, P < 0.0001). The GA/HbA1c ratio was also significantly higher in the patients with severe fibrosis (F3-F4) than in those without severe liver fibrosis (F0-F2) (3.03 ± 0.41 vs 2.84 ± 0.24, P < 0.001). Furthermore, the GA/ HbA1c ratio was also significantly higher in the patients with significant fibrosis (F2-F4) than in those without significant liver fibrosis (F0-F1) (2.98 ± 0.41 vs 2.83 ± 0.24, P < 0.001). The diagnostic performance of the increased GA/HbA1c ratio (> 3.0) was as follows: its sensitivity and specificity for the detection of liver cirrhosis (F4) were 59.3% and 70.4%, respectively and its sensitivity and specificity for the detection of severe liver fibrosis (F3-F4) were 50.0% and 74.4%,respectively. With regard to the detection of significant fibrosis (F2-F4), its sensitivity was 44.4% and its specificity was 77.0%. Although even the excellent marker APRI shows low sensitivity (25.9%) for distinguishing patients with or without significant fibrosis, the combination of the APRI and GA/HbA1c ratio increased the sensitivity up to 42.0%, with only a modest decrease in the specificity (from 90.2% to 83.6%). CONCLUSION: The GA/HbA1c ratio increased in line with the histological severity of liver fibrosis, thus suggesting that this ratio is useful as a supportive index of liver fibrosis. | Nobuhiro Aizawa Hirayuki Enomoto Hiroyasu Imanishi Masaki Saito Yoshinori Iwata Hironori Tanaka Naoto Ikeda Yoshiyuki Sakai Tomoyuki Takashima Takashi Iwai Ei-ichiro Moriwaki Soji Shimomura Hiroko Iijima Hideji Nakamura Shuhei Nishiguchi | 2012 | World Journal of Hepatology2012，4，1： | 10 |
| 10 | Dispersoid Formation and Recrystallization Behavior in an Al-Mg-Si-Mn Alloy显示文摘The nucleation and precipitation of Mn-containing dispersoids in an Al-Mg-Si-Mn alloy (6082) have been studied by optical microscopy,EPMA (electron probe microanalysis) and TEM (transmission electron microscopy).The influence of Mn-containing dispersoids on the recrystallization behavior was also investigated.The size and distribution of dispersoids were strongly affected by both the homogenization process and the alloying element distribution formed in the direct chill cast procedure.The Mn-containing dispersoids were observed to nucleate preferentially on the β-Mg 2 Si phase and to be aligned along the <100> direction of the matrix.After cold deformation,the morphology of dispersoids greatly influences the recrystallization and grain growth behavior in the annealing process. | Rong Hu Tomo Ogura Hiroyasu Tezuka Tatsuo Sato Qing Liu | 2010 | Journal of Materials Science & Technology2010，26，3： | 10 |
| 11 | Pink-color sign in esophageal squamous neoplasia, and speculation regarding the underlying mechanism显示文摘AIM:To investigate the reasons for the occurrence of the pink-color sign of iodine-unstained lesions. METHODS:In chromoendoscopy, the pink-color sign of iodine-unstained lesions is recognized as useful for the diagnosis of esophageal squamous cell carcinoma. Patients with superficial esophageal neoplasms treated by endoscopic resection were included in the study. Areas of mucosa with and without the pink-color sign were evaluated histologically. The following histologic features that were possibly associated with the pinkcolor sign were evaluated. The keratinous layer and basal cell layer were classified as present or absent. Cellular atypia was classified as high grade, moderate grade or low grade, based on nuclear irregularity, mitotic figures, loss of polarity, chromatin pattern and nuclear/cytoplasmic ratio. Vascular change was assessed based on dilatation, tortuosity, caliber change and variability in shape. Vessels with these four findings were classified as positive for vascular change. Endoscopic images of the lesions were captured immediately after iodine staining, 2-3 min after iodine staining and after complete fading of iodine staining. Quantitative analysis of color changes after iodine staining was also performed. RESULTS:A total of 61 superficial esophageal neoplasms in 54 patients were included in the study. The lesions were located in the cervical esophagus in one case, the upper thoracic esophagus in 10 cases, the mid-thoracic esophagus in 33 cases, and the lower thoracic esophagus in 17 cases. The median diameter of the lesions was 20 mm (range:2-74 mm). Of the 61 lesions, 28 were classified as pink-color sign positive and 33 as pink-color sign negative. The histologic diagnosis was high-grade intraepithelial neoplasia (HGIN) or cancer invading into the lamina propria in 26 of the 28 pink-color sign positive lesions. There was a significant association between pink-color sign positive epithelium and HGIN or invasive cancer (P = 0.0001). Univariate analyses found that absence of the keratinous layer and cellular atypia were significantly associated with the pink-color sign. After Bonferroni correction, there were no significant associations between the pink-color sign and presence of the basal membrane or vascular change. Multivariate analyses found that only absence of the keratinous layer was independently associated with the pink-color sign (OR = 58.8, 95%CI:5.5-632).Quantitative analysis was performed on 10 superficial esophageal neoplasms with both pink-color sign positive and negative areas in 10 patients. Pink-color sign positive mucosa had a lower mean color value in the late phase (pinkish color) than in the early phase (yellowish color), and had similar mean color values in the late and final phases. These findings suggest that pinkcolor positive mucosa underwent color fading from the color of the iodine (yellow) to the color of the mucosa (pink) within 2-3 min after iodine staining. Pink-color sign negative mucosa had similar mean color values in the late and early phases (yellowish color), and had a lower mean color value in the final phase (pinkish color) than in the late phase. These findings suggest that pink-color sign negative mucosa did not undergo color fading during the 2-3 min after iodine staining, and underwent color fading only after spraying of sodium thiosulfate. CONCLUSION:The pink-color sign was associated with absence of the keratinous layer. This sign may be caused by early fading of iodine staining. | Ryu Ishihara Hiromitsu Kanzaki Hiroyasu Iishi Kengo Nagai Fumi Matsui Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Noriya Uedo Masaharu Tatsuta Yasuhiko Tomita Shingo Ishiguro | 2013 | World Journal of Gastroenterology2013，19，27： | 10 |
| 12 | Effect of biliary obstruction and internal biliary drainage on hepatic cytochrome P450 isozymes in rats显示文摘AIM: To investigate the total cytochrome P450 (CYP) content, microsomal mixed-function oxidase (MFO) activity, and expression of mRNAs for various CYP isozymes in a simple rat model of reversible obstructive jaundice. METHODS: Obstructive jaundice was created in male rats by causing bile duct obstruction with polyester tape. In another group of rats, bile duct obstruction was followed by internal biliary drainage after releasing the tape. The expression of various CYP isozyme mRNAs was semi-quantitatively assessed by competitive RT- PCR. RESULTS: The total CYP content and microsomal MFO activity showed a significant decrease after biliary obstruction, but returned to respective control levels after biliary drainage. A marked reduction in the expression of CYP1A2, 2B1/2, 2C11, 2E1, 3A1, and 3A2 mRNA was detected during biliary obstruction, while expression increased significantly toward the control level after biliary drainage. Although expression of CYP4A1 mRNA showed no reduction during biliary obstruction, it still increased significantly after biliary drainage. CONCLUSION: These results suggest that not only obstructive jaundice, but also the subsequent internal biliary drainage may affect regulatory medications of the synthesis of individual CYP isozymes differently. | Shintaro Fukushima Hiroyasu Okuno Nobuyuki Shibatani Yoshitsugu Nakahashi Toshihito Seki Kazuichi Okazaki | 2008 | World Journal of Gastroenterology2008，14，16： | 7 |
| 13 | 21世纪柴油机降低油耗和排放的关键技术显示文摘本文论述了下世纪柴油机降低油耗和排放所需关键技术的现状。这些技术可分为三门:燃油、燃油系统和后处理。它们所体现的新发展在于采用共轨式电控燃油喷射装置、中置式喷油器和四气门气缸盖。要使柴油机能在很长一段时期内保持其竞争力,需要合理地综合应用这些技术。 | Hiroyuki Hiroyasu 李翼龙 | 2002 | 柴油机2002，，2： | 6 |
| 14 | A multicenter retrospective study of endoscopic resection for early gastric cancer显示文摘 | Ichiro Oda Daizo Saito Masahiro Tada Hiroyasu Iishi Satoshi Tanabe Tsuneo Oyama Toshihiko Doi Yoshihide Otani Junko Fujisaki Yoichi Ajioka Tsutomu Hamada Haruhiro Inoue Takuji Gotoda Shigeaki Yoshida | 2006 | Gastric Cancer2006，，4： | 6 |
| 15 | Treatment of bleaching wastewater from pulp paper plants in China using enzymes and coagulants显示文摘The treatment of wastewater from pulp\|paper plants in China by horseradish peroxidase was investigated in this study. The effects of horseradish peroxidase and coagulants were discussed in detail. The results indicated that enzymes might improve the removal of AOX, TOC and colour for pulp\|paper wastewater and modified chitosan is far more effective than Al\-2(SO\-4)\-3 to remove AOX, TOC and colour. | ZHANG Tong\+1, Shinji Wada\+2, Takao Yamagishi\+2, Ichikawa Hiroyasu\+2, Kenji Tatsumi\+ 2* , ZHAO Qing\|xiang\+1 (1. Department of Environmental Engineering, East China University of Science and Technology, Shanghai 200237,China 2. National Institut | 1999 | Journal of Environmental Sciences1999，11，4： | 5 |
| 16 | 城市污水SBR法短程生物脱氮系统硝化菌群的定量分析显示文摘为了研究实时控制对短程生物脱氮中试系统内硝化菌群结构组成的影响,在考察系统常温条件下处理城市污水时短程硝化效果的同时,采用FISH、PCR-DGGE和PCR-克隆序列(Cloning Sequencing)分子生物学方法对SBR中试系统(有效容积为54 m^3)硝化菌群中的氨氧化菌(AOB)和亚硝酸氧化菌(NOB)进行定性与定量化分析.FISH结果表明,在短程脱氮系统中,AOB相比于NOB已成为明显的优势菌群,占总菌群的3%~12%;且没有检测出NOB.PCR-DGGE结果表明,SBR短程脱氮中试系统中的AOB均以Nitrosomonas-like为主.污泥样品的PCR-Cloning-Sequencing结果表明,所有的克隆相似于Nitrosomonas,其中60%以上的克隆相似于Nitro- somonas europaea. | 杨庆 彭永臻 曾薇 杨岸明 Hiroyasu Satoh Takashi Mino | 2007 | 北京工业大学学报2007，33，8： | 5 |
| 17 | Crowned dens syndrome developed after an endoscopic retrograde cholangiopancreatography procedure显示文摘We present a unique case of crowned dens syndrome(CDS) that developed after endoscopic retrograde cholangiopancreatography(ERCP) in a patient who presented with fever and neck pain. Administration of non-steroidal anti-inflammatory drugs was extremely effective for relieving fever and neck pain, and in the improvement of inflammatory markers. To the best of our knowledge, this is the first case report of CDS caused by an ERCP procedure. In a patient with fever and neck pain after an ERCP procedure, CDS should be considered in the differential diagnosis. | Hiroyasu Nakano Kazunari Nakahara Yosuke Michikawa Keigo Suetani Ryo Morita Nobuyuki Matsumoto Fumio Itoh | 2016 | World Journal of Gastroenterology2016，22，39： | 5 |
| 18 | Pharmacological characteristics of Kampo medicine as a mixture of constituents and ingredients显示文摘Herbal medicine in Japan is termed as Kampo medicine, which is derived from traditional Chinese medicine. Shakuyakukanzoto (Shao-Yao-Gan-Cao-Tang) as a kind of Kampo formulations is composed of just two components; Paeoniae Radix and Glycyrrhizae Radix, which produced marked relaxation of intestinal tract. Mokuboito (Mu-Fang-Ji-Tang) inhibited cardiac ionic channel currents, and as a mixture also produced great vasodilatation. Sinomenine (a main ingredient of Mokuboito) as a single compound also caused the vasodilatation, but decreased it along with ageing. Gypsum containing in Mokuboito and Chotosan (Diao-Teng-San) caused more marked effects, as compared with those without Gypsum. On the other hand, Rokumigan (Liu-Wei-Wan), Hachimijiogan (Ba-Wei-Di-Huang-Wan) and Goshajinkigan (Niu-Che-Shen-Qi-Wan) increase in order the number of contained ingredients. The formulations with more herbs (ingredients) produced much more effective actions on rat aorta, presumably due to compensation of the decline of pharmacological sensitivity with ageing. Thus, there are some important differences between single chemical drugs and mixture drugs with many ingredients. The effects of Kampo medicine (mixture) are never just a sum of each effect induced by a lot of ingredients. For elder persons, furthermore, Kampo medicine exerts more effective actions. | Hiroyasu Satoh | 2013 | Journal of Integrative Medicine2013，11，1： | 4 |
| 19 | Effects of Cr and Cr/Mn Combined Additions on Semi-Solid Microstructures of Al-Mg-Si Alloys Produced by D-SSF Process显示文摘Cr 和 Cr/Mn 的效果在半固体微观结构上联合了增加做 Al-Mg-Si 合金被调查。在增加 Cr 的合金, Al7G 混合物被形成与在在粒子在 Cr/Mn-added 合金的一致微观结构被发现的 Al7Cr 和 alpha-Al12Mn3Si2 dispersiod 的 homogenization.Both 以后的 alpha-Al 矩阵同类地分布式。在半固体微观结构,最小的 alpha-Al 谷物在 60% 滚动寒冷的合金被获得。在保持时间延长以后, Cr/Mn-added 合金的 alpha-Al 谷物尺寸比增加 Cr 的合金的小。重变丑由冷滚动加速 alpha-Al 谷物的 spheroidization。D-SSF 过程被发现有用修改两个的微观结构增加 Cr 并且 Cr/Mn-added Al-Mg-Si 合金。 | Witthaya Eidhed Hiroyasu Tezuka Tatsuo Sato | 2008 | Journal of Materials Science & Technology2008，24，1： | 4 |
| 20 | TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis显示文摘 | Charles Thomas Antimo Gioiello Lilia Noriega Axelle Strehle Julien Oury Giovanni Rizzo Antonio Macchiarulo Hiroyasu Yamamoto Chikage Mataki Mark Pruzanski Roberto Pellicciari Johan Auwerx Kristina Schoonjans | 2009 | Cell Metabolism2009，，3： | 4 |
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