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| 1 | Similar efficacy and safety of tenofovir in Asians and non-Asians with chronic hepatitis B显示文摘AIM:To compare the efficacy and safety of tenofovir disoproxil fumarate(TDF)in Asian and non-Asian chronic hepatitis B(CHB)patients.METHODS:The efficacy and safety of the initial 48wk of treatment with TDF was compared in a posthoc analysis of combined data from 217 Asians and299 non-Asians included in Studies 102 and 103and a post-approval,open-label trial(Study 123).Patient groups were compared according to baseline hepatitis B e antigen(HBe Ag)status and viral load.The main outcome measures included the proportion of patients who achieved a hepatitis B virus(HBV)DNA level<400 copies/m L at Week 48 of treatment.Secondary measures included:HBV DNA and alanine aminotransaminase(ALT)levels over time;proportion of patients with normal ALT levels;proportion of patients with HBe Ag loss/seroconversion and proportion of patients with hepatitis B surface antigen loss/seroconversion;changes in liver histology.Safety and tolerability were evaluated by the occurrence of adverse events(AEs),serious AEs,laboratory abnormalities,discontinuation of the study drug due to AEs,or death.The primary efficacy and safety analysis set included all patients who were randomly assigned to treatment and received at least one dose of study drug.RESULTS:At week 48,similar proportions of Asians and non-Asians reached HBV DNA<400 copies/m L(96%of Asian and 97%of non-Asian patients with HBe Ag-negative CHB and 83%of Asian and 79%of non-Asian patients with HBe Ag-positive CHB had HBV DNA)and normal ALT(78%of Asian and 81%of nonAsian patients with HBe Ag-negative CHB and 71%of Asian and 74%of non-Asian patients with HBe Agpositive CHB had normal ALT).On-treatment HBV DNA decline rates were similar between Asians and nonAsians regardless of baseline HBe Ag status and viralload.HBV DNA decline during the first four weeks was2.9 log10 copies/m L in HBe Ag-negative Asians and nonAsians,and in HBe Ag-positive non-Asians,and 3.1log10 copies/m L in HBe Ag-positive Asians.HBe Ag loss and seroconversion was achieved in 14%of Asians vs 26%and 24%,respectively,in non-Asians.Liver histology improved in 77.2%of Asians and 71.5%of non-Asians.No resistance to TDF developed.No renal safety signals were observed.CONCLUSION:TDF demonstrated similar viral suppression,normalization of ALT,improvements in liver fibrosis,and no detectable resistance in Asian and non-Asian patients regardless of baseline HBe Ag status. | Calvin Q Pan Sing Chan Huy Trinh Alan Yao Ho Bae Lillian Lou | 2015 | World Journal of Gastroenterology2015，21，18： | 4 |
| 2 | Genetic variations of the paraoxonase gene in patients with coronary artery disease显示文摘 | Seung Ho Hong Junghan Song Won Ki Min Jin Q Kim | 2001 | Clinical Biochemistry2001，，6： | 2 |
| 3 | Development of adaptive fuzzy control for electrical servo drive via total sliding mode technique显示文摘 | Rong Jong Wait Shun Lin Yu Q Kuo Ho Su | 2004 | FUZZ-IEEE2004，25，29： | 1 |
| 4 | Structure and promoter analysis of an ABAand stress-regulated barley gene HVA1 显示文摘 | Straub P F Shen Q Ho T D | 1994 | Plant Molecular Biology1994，26，： | 1 |
| 5 | Cucurb-itacin B induces apoptosis and S phase cell cycle arrest in BEL-7402human hepatocellular carcinoma cells and is effective via oral admin-istration显示文摘 | Chan KT Meng FY Li Q Ho CY Lam TS To Y | 2010 | Cancer Lett2010，294，1： | 1 |
| 6 | Investigation of adsorption behavior of (-)-epigallocatechin gallate on bovine serum albumin surface using quartz crystal microbalance with dissipation monitoring显示文摘 | Wang X Ho CT Huang Q | 2007 | J Agric Food Chem2007，55，13： | 1 |
| 7 | Dependence of Soecklon Size on the Laser Beam via Photo-induced Light Scattering in LiNbO3∶ Fe显示文摘 | Zhang G Y Li Q X Ho P P | 1986 | Applied Optics1986，25，17： | 1 |
| 8 | Response of Vietnam coastal upwelling to the 1997-1998 ENSO event observed by multisensor data显示文摘 | Kuo N J Zheng Q Ho C | 2004 | Remote Sensing of Environment2004，87，： | 1 |
| 9 | Biometry and primary angle-closure glaucoma among Chi- nese,white, and black populations 显示文摘 | Congdon NG Youlin Q Quigley H Hung PT Wang TH Ho TC et a/ | 1997 | Ophthalmology1997，104，9： | 1 |
| 10 | Effect of ubiquinol- 10 on citral stability and off-flavor formation in oil-in-water (O/W) nanoemulsions显示文摘 | ZHAO Q HO C T HUANG Q R | 2013 | Journal of Agricultural and Food Chemistry2013，，61： | 1 |
| 11 | Satellite observation of upwelling along the western coast of the South China Sea显示文摘 | Kuo N J Zheng Q Ho C | 2000 | Remote Sensing of Environment2000，74，： | 1 |
| 12 | Consensus over directed static networks with arbitrary finite communication delays 显示文摘 | Lu J Q Ho D W Kurths J | 2009 | Physical Review E2009，80，06： | 1 |
| 13 | A new low radiation wireless transmission system in mobile phone application based on magnetic resonant coupling显示文摘 | Chen Q Ho S L Fu W N | 2013 | IEEE Transactions on Magnetics2013，49，7： | 1 |
| 14 | RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein misloealization显示文摘 | ho K Liu Q Tellez M | 2005 | Cancer Res2005，6517，： | 1 |
| 15 | Order-nspectral method for electromagnetic waves显示文摘 | Chan C T Yu Q I Ho K M | 1995 | Phys Rev B1995，51，16： | 1 |
| 16 | Natural mutations in the receptor binding domain of spike glycopro- tein determine the reactivity of cross-neutralization between palm civet coronavirus and severe acute respiratory syn- drome coronavirus 显示文摘 | Liu L Fang Q Deng F Wang H Yi CE Ba L Yu W Lin RD Li T Hu Z Ho DD Zhang L Chen Z | 2007 | J Virol2007，81，9： | 1 |
| 17 | A frequency domain anal- ysis of the effects of nonlinear damping on the Duffing e- quation 显示文摘 | Ho C Lang Z Q Billings S A | 2014 | Mechanical Systems & Signal Processing2014，45，1： | 1 |
| 18 | Soy Intake and the Maintenance of Peak Bone Mass in Hong Kong Chinese Women显示文摘 | Ho SC Chan SG Yi Q | 2001 | Journal of Bone and Mineral Research2001，16，7： | 1 |
| 19 | Seasonal variability of sea surface height in the South China Sea observed with TOPEX/Poseidon altimeter data显示文摘 | Ho C R Zheng Q N SoongYS | 2000 | Journal of Geophysical Research2000，105，13： | 1 |
| 20 | Satellite observation and model simulation of upper ocean biophysical response to Super Typhoon Nakri显示文摘 | Zheng Z Ho C Zheng Q | 2010 | Continental Shelf Research2010，30，13： | 1 |
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