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| 1 | Laparoscopic Partial Nephrectomy With Segmental Renal Artery Clamping:Technique and Clinical Outcomes显示文摘Background:Warm ischemic injury is one of the most important factors affecting renal function in partial nephrectomy(PN).The technique of segmental renal artery clamping emerges as an alternative to conventional renal artery clamping for renal hilar control.Objective:To evaluate the feasibility and efficiency of laparoscopic PN(LPN) with segmental renal artery clamping in comparison with the conventional technique.Design,setting,and participants:A total of 75 patients underwent LPN from June 2007 to November 2009.All patients had T1a or T1b tumor in one kidney and a normal contralateral kidney.Thirty-seven patients underwent surgeries with main renal artery clamping,and 38 underwent surgeries with segmental artery clamping.Intervention:All procedures were performed by the same laparoscopic surgeon.Measurements:Blood loss,operation time,warm ischemia(WI) time,and complications affected renal function before and after operation were recorded.Results and limitations:All LPNs were completed without conversion to open surgery or nephrectomy.The novel technique slightly increased WI time(p < 0.001) and intraoperative blood loss(p = 0.006),while it provided better postoperative affected renal function(p < 0.001) compared with the conventional technique.The total complication rate was 12%.Among the 38 cases where segmental renal artery clamping was performed,7 had to convert to the conventional method.Tumor size and location influenced the number of clamped segmental arteries.Long-term postoperative renal function is still awaited.Conclusions:LPN with segmental artery clamping is safe and feasible in clinical practice.It minimizes the intraoperative WI injury and improves early postoperative affected renal function compared with main renal artery clamping.(C) 2010 European Association of Urology.Published by Elsevier B.V.All rights reserved. | Shao,P.F. Qin,C. Yin,C.J. Meng,X.X. Ju,X.B. Li,J. Lü,Q.A. Zhang,W. Xu,Z.Q.Shao,Pengfei Qin,Chao Yin,Changjun Meng,Xiaoxin Ju,Xiaobing Li,Jie Lü,Qiang Zhang,Wei Xu,Zhengquan] Nanjing Med Univ,Affiliated Hosp 1,Dept Urol,Nanjing,Peoples R China.Guangzhou Rd 300,Nanjing 210029,Peoples R China. | 2011 | 南京医科大学学报(自然科学版)2011，31，7： | 123 |
| 2 | High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy. | Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 13 |
| 3 | The level of oncogene H-Ras correlates with tumorigenicity and malignancy显示文摘Normal bovine adrenocortical cells and some human fibroblasts can be transformed by SV40T and H-Ras in a Ras-dependent manner. We recently reported that high levels of Ras derived from 5' LTR of retrovirrus can induce highly malignant and fast growing tumors, while lower levels of Ras derived from internal ribosome entry site(IRES) promotes slower tumor growth and loss of malignancy. Ras derived from CMV promoters resulted in much lower Ras levels and loss of tumor malignancy and growth. Further studies showed that the tumors formed in the presence of lower levels of Ras and dominant negative P53(P53DD) had fewer apoptotic cells and grew faster than the tumors formed from cells with same level Ras and SV40T. Our studies suggest that low levels of Ras are insufficient to inhibit apoptosis induced by pRb inactivation. In contrast, high levels of Ras not only allow normal cells to exit senescence and form tumors, but also protect against pRb inhibition-induced cell apoptosis. | Sun, B. C. Gao, Y. Deng, L. Li, G. Q. Cheng, F. Wang, X. H. Nanjing Med Univ, Liver Transplantat Ctr, Affiliated Hosp 1, Jiangsu 210029, Peoples R China. Nanjing Med Univ, Liver Transplantat Ctr, Ctr Canc, Jiangsu 210029, Peoples R China. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 3 |
| 4 | Polymorphisms of surfactant protein B encoding gene:modifiers of the course of neonatal respiratory distress syndrome显示文摘 | Makri V Hospes B Stoll-Becker S | 2002 | Eur J Pediatr2002，161，11： | 1 |
| 5 | En- hancement of daily physical activity increases physical fitness of outclinic COPD patients:Results of an exercise counseling program显示文摘 | Hospes G Bossenbroek L Ten Hacken NH | 2009 | Patient Educ Couns2009，75，2： | 1 |
| 6 | Twice weeklytuberculosis preventive therapy in HIV infection in Zambia 显示文摘 | Mwinga A Hosp M Godfrey - Fau ssett P | 1998 | AIDS1998，12，18： | 1 |
| 7 | The effect of a multifaceted educational intervention on medication prepara- tion and administration errors in neonatal intensive care显示文摘 | Chedoe I Molendijk H Hospes W | 2012 | Arch Dis Child Fetal Neonatal Ed2012，97，6： | 1 |
| 8 | A study of insight and its relative factors in schizophrenia.显示文摘Objective: To determine the clinical value of the insight and its relative factors in schizophrenic patients. Methods: The insight, the brief psychiatric rating scale (BPRS), the scale for the assessment of negative symptoms (SANS), the scale for the assessment | GAN Jingli, et al. Ment Health Center, 160th Hosp, Jinan Command, Jiaozhuo, 454003 | 1997 | China Medical Abstracts(Internal Medicine)1997，14，2： | 1 |
| 9 | Analyzing protein-protein interactions by quantitative mass spectrometry 显示文摘 | Paul F E Hosp F Selbach M | 2011 | Methods2011，54，4： | 1 |
| 10 | Incidence, and outcome of delirium in study from India 显示文摘 | Sharma A Malhotra S prevalence risk factor intensive care unit: a Hosp Psychiatry 2012 Grover S | 2012 | Gen2012，34，6： | 1 |
| 11 | Dopaminergic meso-corlical projections to M1 : role in motor learning and motor cortex plasticity显示文摘 | Hosp JA Nolan HE Luft AR | 2013 | Front Neurol2013，54，15： | 1 |
| 12 | Flow Cytometrie Assessment of Spermatogenesis in Infertile Men by DAPI-Sulphorodamine Staining and Vimentin/DNA Biparametric Analysis显示文摘 | ST CHIARA HOSP DEPT PATHOL TRENT | 2004 | Cytometry Part A2004，，59： | 1 |
| 13 | Significance of the neutrophil-lymphocyte ratio in elderly type 2 diabetic patients with coronary heart disease显示文摘Objective To evaluate the value of the neutrophillymphocyte ratio(NLR)in elderly type 2 diabetic patients(T2DM)with coronary heart disease(CHD).Methods We performed a retrospective observational study on 228 patients undergoing coronary angiography | Dept Endocrinol,Guizhou Prov People’s Hosp | 2016 | China Medical Abstracts(Internal Medicine)2016，33，2： | 1 |
| 14 | Twice weekly tuberculosis preventive therapy in HIV infection in Zambia显示文摘 | Mwinga AG Hosp M Godfrey Faussett P | 1998 | AIDS1998，12，： | 1 |
| 15 | Twice weeklytuberculosis preventive therapy in HIV infection in Zambia 显示文摘 | Mwinga A Hosp M Godfrey - F au ssett P | 1998 | AIDS1998，12，18： | 1 |
| 16 | Long term effect of preventive therapy for tuberculosis in a cohort of HIV-infected Zambian patients显示文摘 | Quigley MA Mwinga A Hosp M | 2001 | AIDS2001，15，2： | 1 |
| 17 | China’sresourcesandland-usechange:in-sightsfromthe1996landsurvey显示文摘 | LinGCS HoSPS | 2003 | LandUsePolicy2003，20，： | 1 |
| 18 | Long-term effect ofpreventive therapy for tuberculosis in a cohort of HIV-infectedZambian adults显示文摘 | Quigley MA Mwinga A Hosp M | 2001 | AIDS2001，15，2： | 1 |
| 19 | Long-term effect of preventive therapy for tuberculosis in a cohort of HIV-infected Zambian adults显示文摘 | Qyugket MA Mwinga A Hosp M | 2001 | AIDS2001，15，2： | 1 |
| 20 | Twice weekly tuberculosis preventive therapy in HIV infection in Zambia显示文摘 | Mwinga A Hosp M Godfrey-Faussett P | 1998 | AIDS1998，12，： | 1 |
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