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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Antiviral activity of glycyrrhizic acid derivatives against SARS coronavirus显示文摘 | Hoever G Baltina L Michaelis M | 2005 | J Med Chem2005，48，： | 1 |
| 3 | Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus显示文摘 | Lidia Baltina Martin Michaelis | 2005 | J Med Chem2005，48，： | 1 |
| 4 | Supernormal Muscle Fiber Conduction Velocity during Intermittent Isometric Exercise in Human Muscle显示文摘 | VAN DER HOEVER J H LANGE F | 1994 | J Appl Physiol1994，77，： | 1 |
| 5 | Supernormal muscle fiber conduction velocity during intermittent isometric exercise in human muscle显示文摘 | VAN DER HOEVER J H LANGE F | 1994 | J Appl Physiol1994，77，： | 1 |
| 6 | Orexiin receptor antagonism:an ascending multiple--dose study with almorex- ant显示文摘 | Hoever P de Haas SL Dorffner G | 2012 | J Psychopharmaclo2012，26，8： | 1 |
| 7 | Development of antiviral therapy for severe acute respiratory syndrome 显示文摘 | Cinatl J Jr Michaelis M Hoever G | 2005 | Antiviral Res2005，66，23： | 1 |
| 8 | Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus显示文摘 | Hoever G Baltina L MichaelisM et a1 | 2005 | J Med Chem2005，48，： | 1 |
| 9 | Development of antiviral therapy for severe acute respiratory syndrome显示文摘 | CINATL J JR MICHAELIS M HOEVER G | 2005 | Antiviral Res2005，66，23： | 1 |
| 10 | Antiviral ac- tivity of glycyrrhizic acid derivatives against SARS- coronavirus显示文摘 | Hoever G Baltina L Michaelis M | 2005 | J Med Chem2005，48，4： | 1 |
| 11 | Antiviral ac-tivity of glycyrrhizic acid derivatives against SARS- coronavirus 显示文摘 | Hoever G Baltina L Michaelis M | 2005 | J Med Chem2005，48，4： | 1 |
| 12 | JCAMP-CS: A standard exchange format for chemical structure information in computer-readable form显示文摘 | Gasteiger J Hendriks B M P Hoever P | 1991 | Appl Spectrosc1991，45，1： | 1 |
| 13 | Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus显示文摘 | Hoever G Baltina L Michaelis M | | 0，，04： | 1 |
| 14 | Fostering team creativity: perspective taking as a key to unlocking diversity's potential显示文摘 | HOEVER I J VAN KNIPPENBERG D VAN GINKEL | 2012 | Journal of Applied Psy ehology2012，97，5： | 1 |
| 15 | Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus显示文摘 | HOEVER G BALTINA L MICHAELIS M | 2005 | J Med Chem2005，48，： | 1 |
| 16 | Restriction-fragment-length polymorphism analysis of small-subunit rRNA genes of Blastocystis hominis isolates from geographically diverse human hosts显示文摘 | J. Hoevers P. Holman K. Logan M. Hommel R. Ashford K. Snowden | 2000 | Parasitology Research2000，，1： | 1 |
| 17 | Antiviral activity of glycyrrhizic acid derivatives against SARScoronavirus显示文摘 | HOEVER G BALTINA L MICHAELIS M | 2005 | J Med Chem2005，48，： | 1 |
| 18 | Bicteriocins with potential for use in foods显示文摘 | HOEVER D G | 1993 | Antimicrobials in food1993，，： | 1 |
| 19 | Antiviral activity of glyeyrrhizie acid derivatives against SARS-eoronavirus显示文摘 | Hoever G Bahina L Miehaelis M | 2005 | J Med Chem2005，48，4： | 1 |
| 20 | Fostering Team Greativity:Perspective Taking as Key to Unlocking Diversity's Potential显示文摘 | Hoever I J van Knippenery D van Ginkel W p | 2012 | Journal of Applied Psychology2012，97，5： | 1 |
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