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| 1 | Type 3 innate lymphoid cell-derived lymphotoxin prevents microbiota-dependent inflammation显示文摘Splenomegaly is a well-known phenomenon typically associated with inflammation.However,the underlying cause of this phenotype has not been well characterized.Furthermore,the splenomegaly phenotype seen in lymphotoxin(LT)signaling-deficient mice is characterized by increased numbers of splenocytes and splenic neutrophils.Splenomegaly,as well as the related phenotype of increased lymphocyte counts in non-lymphoid tissues,is thought to result from the absence of secondary lymphoid tissues in LT-deficient mice.We now present evidence that mice deficient in LTα1β2 or LTβR develop splenomegaly and increased numbers of lymphocytes in non-lymphoid tissues in a microbiota-dependent manner.Antibiotic administration to LTα1β2-or LTβR-deficient mice reduces splenomegaly.Furthermore,re-derived germ-free Ltbr−/−mice do not exhibit splenomegaly or increased inflammation in non-lymphoid tissues compared to specific pathogen-free Ltbr−/−mice.By using various LTβ-and LTβR-conditional knockout mice,we demonstrate that retinoic acid-related orphan receptorγT-positive type 3 innate lymphoid cells provide the required active LT signaling to prevent the development of splenomegaly.Thus,this study demonstrates the importance of LT-mediated immune responses for the prevention of splenomegaly and systemic inflammation induced by microbiota. | Yuan Zhang Tae-Jin Kim Joanna A Wroblewska Vera Tesic Vaibhav Upadhyay Ralph R Weichselbaum Alexei V Tumanov Hong Tang Xiaohuan Guo Haidong Tang Yang-Xin Fu | 2018 | Cellular & Molecular Immunology2018，15，7： | 3 |
| 2 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hvfwpfnv5w5uq6vk6.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 3 | International experts consensus guidelines on robotic liver resection in 2023显示文摘The robotic liver resection(RLR)has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system,however,controversies still exist.Based on the foundation of the previous consensus statement,this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical practice.The guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine(EBM).Relevant literature was reviewed and analyzed by the evidence evaluation group.According to the WHO Handbook for Guideline Development,the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022,a total of 14 recommendations were generated.Among them were 8 recommendations formulated by the GRADE method,and the remaining 6 recommendations were formulated based on literature review and experts’opinion due to insufficient EBM results.This international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future. | Rong Liu Mohammed Abu Hilal Go Wakabayashi Ho-Seong Han Chinnusamy Palanivelu Ugo Boggi Thilo Hackert Hong-Jin Kim Xiao-Ying Wang Ming-Gen Hu Gi Hong Choi Fabrizio Panaro Jin He Mikhail Efanov Xiao-Yu Yin Roland S Croner Yu-Man Fong Ji-Ye Zhu Zheng Wu Chuan-Dong Sun Jae Hoon Lee Marco V Marino Iyer Shridhar Ganpati Peng Zhu Zi-Zheng Wang Ke-Hu Yang Jia Fan Xiao-Ping Chen Wan Yee Lau | 2023 | World Journal of Gastroenterology2023，29，32： | 2 |
| 4 | Interactive venation-based leaf shape modeling显示文摘 | Sung Min Hong Bruce Simpson Gladimir V G Baranoski | 2005 | Computer Animation and Virtual Worlds2005，16，34： | 1 |
| 5 | High levels of population differentiation for mitochondrial DNA haplotypesin Pinus radiata显示文摘 | Strauss S H Hong Y P Hipkins V D | | 0，，： | 1 |
| 6 | Radiation-induced graft polymerization of glycidyl methacrylate onto nonwoven polypropylene显示文摘 | Bondar Yu V Hong Je Kim Yong Jin Lim | 2005 | Russian Journal of Applied Chemistry2005，78，5： | 1 |
| 7 | Robust feedback con- trol of combustion instability with modeling uncertain- ty 显示文摘 | HONG B YANG V RAY A | 2000 | Combustion and Flame2000，120，： | 1 |
| 8 | A novel melanin-like pigment derived from black tea leaves with immuno-stimulating activity 显示文摘 | Sava V M Galkin B N Hong M Y | 2001 | Food Research International2001，34，4： | 1 |
| 9 | Strain increment and stress directions in torsion shear tests显示文摘 | HONG W P LADE P V | 1989 | Journal of Geotechnical Engineering1989，115，10： | 1 |
| 10 | Soil pH effect on phosphate induced cadmium precipitation in arable soil显示文摘 | Hong C O Owens V N Kim Y G | 2014 | Bulletin of Environmental Contamination and Toxicology2014，93，1： | 1 |
| 11 | A nanoliter-scale nucleic acid processor with parallel architecture显示文摘 | Hong J W Studer V Hang G | 2004 | Nature Biotechnology2004，22，： | 1 |
| 12 | Tlalpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema 显示文摘 | Schacht V Ramirez MI Hong Yk | 2003 | EMBO J2003，22，14： | 1 |
| 13 | An on-line replication strategy to increase availability in Data Grids 显示文摘 | Lei M Vrbsky S V Hong X | 2008 | Future Generation Computer Systems2008，24，： | 1 |
| 14 | Evidence that a tran- scription factor regulatory network coordinates oxidative stress response and secondary metabolism in Aspergilli 显示文摘 | Hong S Y Roze L V Wee J | 2013 | Microbiologyopen2013，2，1： | 1 |
| 15 | Development and evaluation of a novel loop mediated isothermal amplification method for rapid detection of sever acute respiratory syndrome coronavirus显示文摘 | Hong T C Mai Q L Cuong D V | 2004 | Journal of Clinic Microbiology2004，4，： | 1 |
| 16 | Geochemical variation of soil-gas composition forfault trace and earthquake precursory studies along the Hsin- cheng fault in NW Taiwan 显示文摘 | Walia V Yang T F Hong W L Lin S J Fu C C Wen K L Chen C H | 2009 | Applied Radiation and Iso- topes2009，67，： | 1 |
| 17 | Observation of Ferromagnetism at Room Temperature in ZnO Thin Films 显示文摘 | HONG N H SAKAI J BRIZE V | 2007 | J Phys Condens Matter2007，19，03： | 1 |
| 18 | Starting regions by fixed points and tightening显示文摘 | HONG H STAHL V | 1995 | Computing1995，53，34： | 1 |
| 19 | Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells显示文摘 | KAUSHAL GP KAUSHAL V HONG X | 2001 | Kidney Int2001，60，5： | 1 |
| 20 | An on-line replication strategy to increase availability in data grids 显示文摘 | Lei Ming Vrbsky S V Hong Xiaoyan | 2008 | Future Generation Computer Systems2008，24，2： | 1 |
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