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| 1 | Possible inhibition of focal cerebral ischemia by angiotensin Ⅱ type 2 receptor stimulation 显示文摘 | Masaru I Hong WL Rui C | 2004 | Circulation2004，110，： | 1 |
| 2 | Influence of Intron and Exon Splicing Enhancers on Mammalian Cell Expression of a Truncated Spike Protein of SARS-CoV and Its Implication for Subunit Vaccine Development 显示文摘 | Chia- Yin Chang Willy WL Hong Pele Chong | 2006 | Vaccine2006，24，8： | 1 |
| 3 | A modified visual loop-mediated isothermal amplieation method for diagnosis and differentiation of main pathogens from My- eobacterium tuberculosis complex 显示文摘 | Hong M Zha L Fu WL Zou MJ Li WJ Xu DG | 2012 | Mierobiol Biotechn- ol2012，28，： | 1 |
| 4 | Pharmacokinetics and anti- asthmatic potential of non-parenterally administered recombinant human interleukin-1 receptor antagonist in animal models 显示文摘 | Li T Lu WL Hong HY | 2006 | JPharmacol Sci2006，102，2： | 1 |
| 5 | Tetracycline-regulated intratumoral expression of interleukin-3 enhances the efficacy of radiation therapy for murine prostate cancer显示文摘 | Tsai CH Hong JH Hsieh KF Hsiao HW Chuang WL Lee CC | 2006 | Cancer Gene Ther2006，13，12： | 1 |
| 6 | NAD+ treatment can block rotenone-induced nuclear apoptotic changes of PC12 cells显示文摘 | Hong YW Shao JX Xia WL | | 0，，： | 1 |
| 7 | Ankle muscle activation during functional reach in hemiparetic and healthy subjects 显示文摘 | Hsu WL Yang YR Hong CT | 2005 | Am J Phys Med Rehabil2005，84，10： | 1 |
| 8 | Substance P potentiates ATP-activated currents in rat primary sensory neurons显示文摘 | Zhi WL | 1996 | Brain Res1996，739，： | 1 |
| 9 | Can we omit systematic biopsies in patients undergoing MRI fusion-targeted prostate biopsies?显示文摘Magnetic resonance imaging(MRI)-targeted prostate biopsy is the recommended investigation in men with suspicious lesion(s)on MRI.The role of concurrent systematic in addition to targeted biopsies is currently unclear.Using our prospectively maintained database,we identified men with at least one Prostate Imaging-Reporting and Data System(PI-RADS)≥3 lesion who underwent targeted and/or systematic biopsies from May 2016 to May 2020.Clinically significant prostate cancer(csPCa)was defined as any Gleason grade group≥2 cancer.Of 545 patients who underwent MRI fusion-targeted biopsy,222(40.7%)were biopsy naïve,247(45.3%)had previous prostate biopsy(s),and 76(13.9%)had known prostate cancer undergoing active surveillance.Prostate cancer was more commonly found in biopsy-naïve men(63.5%)and those on active surveillance(68.4%)compared to those who had previous biopsies(35.2%;both P<0.001).Systematic biopsies provided an incremental 10.4%detection of csPCa among biopsy-naïve patients,versus an incremental 2.4%among those who had prior negative biopsies.Multivariable regression found age(odds ratio[OR]=1.03,P=0.03),prostate-specific antigen(PSA)density≥0.15 ng ml^(−2)(OR=3.24,P<0.001),prostate health index(PHI)≥35(OR=2.43,P=0.006),higher PI-RADS score(vs PI-RADS 3;OR=4.59 for PI-RADS 4,and OR=9.91 for PI-RADS 5;both P<0.001)and target lesion volume-to-prostate volume ratio≥0.10(OR=5.26,P=0.013)were significantly associated with csPCa detection on targeted biopsy.In conclusion,for men undergoing MRI fusion-targeted prostate biopsies,systematic biopsies should not be omitted given its incremental value to targeted biopsies alone.The factors such as PSA density≥0.15 ng ml^(−2),PHI≥35,higher PI-RADS score,and target lesion volume-to-prostate volume ratio≥0.10 can help identify men at higher risk of csPCa. | Jeffrey J Leow Soon Hock Koh Marcus WL Chow Wayren Loke Rolando Salada Seok Kwan Hong Yuyi Yeow Chau Hung Lee Cher Heng Tan Teck Wei Tan | 2023 | Asian Journal of Andrology2023，25，1： | 0 |
| 10 | Effects of primary glaucoma on sleep quality and daytime sleepiness of patients residing at an equatorial latitude显示文摘AIM:To investigate the impact of primary glaucoma on sleep quality and daytime sleepiness of patients.METHODS:Prospective cross-sectional study with consecutive sampling in South-East Asian population was performed.Validated questionnaires:the Pittsburg Sleep Quality Index(PSQI)and Epworth Sleepiness Scale(ESS)were administered prospectively.Subjects with nonglaucomatous optic neuropathy or concomitant retinal pathology were excluded.Glaucoma severity was based on HVF 24-2 perimetry.Binocular single vision was represented based on the better eye.Frequency of and predictive factors for poor sleep quality and excessive daytime sleepiness were compared.RESULTS:A total of 79 primary open angle glaucoma(POAG),27 primary angle-closure glaucoma(PACG)patients,and 89 controls were recruited.PACG patients had higher median PSQI scores(P=0.004)and poorer sleep quality(P<0.001).Compared to controls,PACG patients were 3.34 times more likely to have poor sleep quality(P=0.008),which remained significant after adjustment for demographics(P=0.016)and predictive variables(P=0.013).PACG patients have poorer sleep quality when visual acuity(VA)was 6/15 or worse(P=0.009).Univariate and multivariate analysis of predictive variables for poor sleep quality and daytime sleepiness did not find statistical significance.CONCLUSION:PACG patients have poorer sleep quality but not daytime sleepiness.This is important in South-East Asian population with heavy disease burden.Evaluations on sleep disturbances can be considered to provide more ho istic care. | Jacob YH Chin Zhi Hong Toh Ying Tai Lo Hannah TY Wang Elizabeth YW Poh Chun Hau Chua Owen Kim Hee Boon Ang Lim Vernon KY Yong Augustinus Laude Hon Tym Wong Leonard WL Yip | 2020 | International Journal of Ophthalmology(English edition)2020，13，9： | 0 |
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