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| 1 | Western medication plus Traditional Chinese Medicine preparations in patients with chronic heart failure:a prospective,single-blind,randomized,controlled,and multicenter clinical trial显示文摘OBJECTIVE: To assess the efficacy and safety in patients with chronic heart failure(CHF) of Western medication plus Traditional Chinese Medicine(TCM) preparations.METHODS: This prospective, single-blind, randomized, controlled, and multicenter clinical trial began on September 17, 2008, and was completed on June 25, 2011. A total of 340 inpatients, aged 40-79 years, with exacerbating CHF from 10 hospitals were enrolled and randomly allocated within 24 h of admission. The trial included three intervention periods. During hospitalization, the control group received western medication for CHF and the treatment group received Danhong injection with Shenfu injection or Shenmai injection. After discharge,all patients were treated with Qiliqiangxin capsules and Buyiqiangxin tablets or a placebo for 6 months. After the 6-month intervention, both groups received only continuous western medication. The primary endpoint was all-cause mortality.The efficacy assessments were as follows: B-type natriuretic peptide(BNP), Lee's HF score, the 6-minute walking test(6 MWT), left ventricular ejection fraction(LVEF), and the Minnesota Living with Heart Failure Questionnaire(MLHFQ). The safety assessments were as follows: blood and urine routine examination, hepatic and renal function, electrolytes in blood and adverse events.RESULTS: Compared with the control group, the treatment group showed a 30.99% reduction in all-cause mortality and an improved survival rate.The treatment group showed greater improvement in 6 MWT(P = 0.02) than the control group on discharge, after 12-month follow-up, there was a time-group interaction for MLHFQ(P = 0.03). Incidence rate of adverse events and other relevant safety indexes were not statistically significant between the two groups.CONCLUSION: Western medication plus TCM treatment can increase 6-minute walking distance(improve exercise tolerance) and quality of life with heart failure patients. | Wang Xianliang Hou Yazhu Mao Jingyuan Zhao Yingqiang Niu Tianfu Yuan Ruyu Wang Yonggang Cui Jin-rong Shi Le Jia Xiuli Fan Ruihong Lin Qian Zhang Yan Li Zhijun Shang Hongcai Wang Baohe Wang Hongwu Wang Henghe Cui Xiaolei Soh Shanbin Ruan Jishou Zhang Boli | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 15 |
| 2 | Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis显示文摘Sodium-glucose cotransporter 2(SGLT2)inhibitors reduce cardiovascular mortality in patients with diabetes mellitus but the protective mechanism remains elusive.Here we demonstrated that the SGLT2 inhibitor,Empagliflozin(EMPA),suppresses cardiomyocytes autosis(autophagic cell death)to confer cardioprotective effects.Using myocardial infarction(Ml)mouse models with and without diabetes mellitus,EMPA treatment significantly reduced infarct size,and myocardial fibrosis,thereby leading to improved cardiac function and survival.In the context of ischemia and nutritional glucose deprivation where autosis is already highly stimulated,EMPA directly inhibits the activity of the Na^(+)/H^(+)exchanger 1(NHE1)in the cardiomyocytes to regulate excessive autophagy.Knockdown of NHE1 significantly rescued glucose deprivation-induced autosis.In contrast,overexpression of NHE1 aggravated the cardiomyocytes death in response to starvation,which was effectively rescued by EMPA treatment.Furthermore,in vitro and in vivo analysis of NHE1 and Beclin 1 knockout mice validated that EMPA s cardioprotective effects are at least in part through downregulation of autophagic flux.These findings provide new insights for drug development,specifically targeting NHE1 and autosis for ventricular remodeling and heart failure after Ml in both diabetic and non-diabetic patients. | Kai Jiang Yue Xu Dandan Wang Feng Chen Zizhuo Tu Jie Qian Sheng Xu Yixiang Xu John Hwa Jian Li Hongcai Shang Yaozu Xiang | 2022 | Protein & Cell2022，13，5： | 13 |
| 3 | Syntheses and characterization of anti-thrombotic and anti-oxidative Gastrodin-modified polyurethane for vascular tissue engineering显示文摘Vascular grafts must avoid negative inflammatory responses and thrombogenesis to prohibit fibrotic deposition immediately upon implantation and promote the regeneration of small diameter blood vessels(<6 mm inner diameter).Here,polyurethane(PU)elastomers incorporating anti-coagulative and anti-inflammatory Gastrodin were fabricated.The films had inter-connected pores with porosities equal to or greater than 86%and pore sizes ranging from 250 to 400μm.Incorporation of Gastrodin into PU films resulted in desirable mechanical properties,hydrophilicity,swelling ratios and degradation rates without collapse.The released Gastrodin maintained bioactivity over 21 days as assessed by its anti-oxidative capability.The Gastrodin/PU had better anti-coagulation response(less observable BSA,fibrinogen and platelet adhesion/activation and suppressed clotting in whole blood).Red blood cell compatibility,measured by hemolysis,was greatly improved with 2Gastrodin/PU compared to other Gastrodin/PU groups.Notably,Gastrodin/PU upregulated anti-oxidant factors Nrf2 and HO-1 expression in H2O2 treated HUVECs,correlated with decreasing pro-inflammatory cytokines TNF-αand IL-1β in RAW 264.7 cells.Upon implantation in a subcutaneous pocket,PU was encapsulated by an obvious fibrous capsule,concurrent with a large amount of inflammatory cell infiltration,while Gastrodin/PU induced a thinner fibrous capsule,especially 2Gastrodin/PU.Further,enhanced adhesion and proliferation of HUVECs seeded onto films in vitro demonstrated that 2Gastrodin/PU could help cell recruitment,as evidenced by rapid host cell infiltration and substantial blood vessel formation in vivo.These results indicate that 2Gastrodin/PU has the potential to facilitate blood vessel regeneration,thus providing new insight into the development of clinically effective vascular grafts. | Meng Zheng Jiazhi Guo Qing Li Jian Yang Yi Han Hongcai Yang Mali Yu Lianmei Zhong Di Lu Limei Li Lin Sun | 2021 | Bioactive Materials2021，6，2： | 7 |
| 4 | Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration显示文摘The development of functional materials for osteoporosis is ultimately required for bone remodeling.However,grafts were accompanied by increasing pro-inflammatory cytokines that impaired bone formation.In this work,nano-hydroxyapatite(n-HA)/resveratrol(Res)/chitosan(CS)composite microspheres were designed to create a beneficial microenvironment and help improve the osteogenesis by local sustained release of Res.Study of in vitro release confirmed the feasibility of n-HA/Res/CS microspheres for controlled Res release.Notably,microspheres had anti-inflammatory activity evidenced by the decreased expression of pro-inflammatory cytokines TNF-α,IL-1βand iNOS in RAW264.7 cells in a dose dependent manner.Further,enhanced adhesion and proliferation of BMSCs seeded onto microspheres demonstrated that composite microspheres were conducive to cell growth.The ability to enhance osteo-differentiation was supported by up-regulation of Runx2,ALP,Col-1 and OCN,and substantial mineralization in osteogenic medium.When implanted into bone defects in the osteoporotic rat femoral condyles,enhanced entochondrostosis and bone regeneration suggested that the n-HA/Res/CS composite microspheres were more favorable for impaired fracture healing.The results indicated that optimized n-HA/Res/CS composite microspheres could serve as promising multifunctional fillers for osteoporotic bone defect/fracture treatment. | Limei Li Mali Yu Yao Li Qing Li Hongcai Yang Meng Zheng Yi Han Di Lu Sheng Lu Li Gui | 2021 | Bioactive Materials2021，6，5： | 6 |
| 5 | Analysis Method and Principle of Dual-mode Electro-mechanical Variable Transmission Program显示文摘Automotive industry,as an important pillar of the national economy,has been rapidly developing in recent years.But proplems such as energy comsumption and environmental pollution are posed at the same time.Electro-mechanical variable transmission system is considered one of avilable workarounds.It is brought forward a kind of design methods of dual-mode electro-mechanical variable transmission system rotational speed characteristics and dual-mode drive diagrams.With the motor operating behavior of running in four quadrants and the speed characteristics of the simple internal and external meshing single planetary gear train,four kinds of dual-mode electro-mechanical transmission system scheme are designed.And the velocity,torque and power characteristics of one of the programs are analyzed.The magnitude of the electric split-flow power is an important factor which influences the system performance,so in the parameters matching design,it needs to reduce the power needs under the first mode of the motor.The motor,output rotational speed range and the position of the mode switching point have relationships with the characteristics design of the planetary gear set.The analysis method is to provide a reference for hybrid vehicles' design.As the involved rotational speed and torque relationships are the natural contact of every part of transmission system,a theory basis of system program and performance analysis is provided. | LI Hongcai YAN Qingdong XIANG Changle WANG Weida | 2012 | Chinese Journal of Mechanical Engineering2012，25，3： | 6 |
| 6 | Progress in electrolyte and interface of hard carbon and graphite anode for sodiumion battery显示文摘It is essential to replace lithium-ion batteries(LIBs)from the perspective of the Earth's resources and the sustainable development of mankind.Sodium-ion batteries(SIBs)are important candidates due to their low price and abundant storage capacity.Hard carbon(HC)and graphite have important applications in anode materials of SIBs.In this review,the research progress in electrolyte and interface between HC and graphite anode for SIBs is summarized.The properties and performance of three types of widely used electrolytes(carbo nate ester,ether,and ionic liquid)with additives,as well as the formation of solid electrolyte interface(SEI),which are crucial to the reversible capacity and rate capability of HC anodes,are also discussed.In this review,the co-intercalation performance and mechanism of solvation Na+into graphite are summarized.Besides,the faced challenges and existing problems in this field are also succinctly highlighted. | Qi Liu Rigan Xu Daobin Mu Guoqiang Tan Hongcai Gao Ning Li Renjie Chen Feng Wu | 2022 | Carbon Energy2022，4，3： | 3 |
| 7 | Geology, Geochemistry, and Geochronology of the Fenghuangshan Skarn-type Copper Deposit in the Tongling Ore Cluster, Anhui Province, East China显示文摘The Fenghuangshan skarn-type Cu deposit, Tongling Ore Cluster, Anhui Province, is an important component in the Middle-Lower Yangtze River ore-forming belt. To better understand magmatism and its relationship to mineralization, we investigated geochemical features, ore-forming fluids, and geochronology of the Xinwuli intrusion and the related Fenghuangshan Cu deposit. Lithogeochemical characteristics show that the Xinwuli quartz monzodiorite is formed by mixing magma derived from upper mantle alkaline basalt that has been contaminated by crust materials. C, H and O isotopes indicate that ore-forming fluids mainly come from the magma, with minor amounts of meteoric fluids involved at the late stage. S and Pb isotopic components indicate that ore-forming materials are derived from the mantle. Molybdenite Re-Os isotopic dating yields Re-Os model ages ranging from 139.1±2.4 Ma to 142.0±2.2 Ma, with an isochronal age of 141.1±1.4 Ma, which is consistent with sensitive, high-resolution ion microprobe (SHRIMP) zircon U-Pb ages of quartz monzodiorite and granodiorite in the mining area. Dating analysis yields ages from 136.0±2.0 Ma to 143.0±2.4 Ma for the quartz monzodiorite (a weighted average of 139.4±1.2 Ma) and ages from 136.7±2.0 Ma to 145.3±2.4 Ma for granodiorite (a weighted average of 141.0±1.1 Ma). | QU Hongying PEI Rongfu FEI Hongcai LI Jinwen WANG Yonglei WANG Haolin YAO Lei | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 3 |
| 8 | Eco-friendly PVA/Kaolin Clay Coating for Barrier Paper显示文摘The resistance of wood-fiber paper to water, grease, and water vapor is usually attained by immersing the base paper in hydrophobic oil, laminating with a plastic or metal film, or the application of a barrier coating. Oil impregnation and the addition of films may make the paper difficult to recycle or persistent in the environment owing to their strong binding force and nondegradability. Environmental concerns have attracted worldwide attention to eco-friendly barrier coatings. In this study, degradable polyvinyl alcohol(PVA) and kaolin clay pigment were used to prepare coatings that were applied to a base paper. By measuring the barrier properties of the coated paper, including the water absorptiveness(Cobb60 value), Hercules sizing degree, oil resistance(Kit rating), and water vapor transmission rate(WVTR), an optimal coating formulation and process were proposed. To examine the barrier mechanism of the PVA/kaolin clay coating, we characterized the coating microstructures using a scanning electron microscopy(SEM) and a mercury porosimeter. The results showed that the Cobb60 value and water vapor transmission rate of the coated paper decreased by 61.4% and 98.6%, respectively, compared with the base paper, for a pre-coating weight of 0.98 g/m^2 and a top-coating weight of about 3.23 g/m^2. Furthermore, the Hercules sizing degree rose by a factor of 337.2, while the oil resistance(Kit rating) increased from 0 to 12. The optimum drying temperature for a wet coating layer was found to be 170℃, and the optimum weight ratio of PVA to kaolin clay in the coating was determined to be 50∶50. It was assumed that the PVA/kaolin clay coating improved the smoothness of the paper considerably and decreased the pore size by filling the pores on the paper surface and forming an even film, thus enhancing the paper barrier performance. The coated paper also exhibited good repulpability. | YanFen Du JinGang Liu JiaFu Wang YanQun Su HongCai Li BiSong wang RuiJuan Zhang | 2017 | Paper And Biomaterials2017，2，2： | 3 |
| 9 | A finite-element simulation on deformational energy in structural deformed zone显示文摘Under the same conditions of external force, simulations on differences of deformational energy in structural zones, which have different deformational behavior, and that on the distribution of the differences have been carried out by means of finite-element method. Shear deformational energy U_w is higher than volume deformational energy U_T by about one order of magnitude, and deformationat energy U_B( = U_w + U_T) and U_w show a trend to be larger→largest→small in quantity in structural zones of different deformational properties, which correspond to compressive, shear, tensile zones, respectively, but U_T shows a trend to be large→small gradually. This has a considerable significance in the study of tectonic heat and mineral liquid migration in association with the research on tectonic additional hydrostatic pressure. | Guxian Lü Hongcai Wang Weizhen Peng Xiaobo Li Tao Guo Chusun Guo | 1999 | Chinese Science Bulletin1999，44，11： | 3 |
| 10 | ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage显示文摘Myocardial ischemia/reperfusion(/R)injury is a classic type of cardiovascular disease characterized by injury to cardiomyocytes leading to various forms of cell death.It is believed that irreversible myocardial damage resulted from I/R occurs due to oxidative stress evoked during the reperfusion phase.Here we demonstrate that ischemia triggers a specific redox reaction of polyunsaturated fatty acids(PUFA)-phospholipids in myocardial cells,which acts as a priming signaling that initiates the outbreak of robust oxidative damage in the reperfusion phase.Using animal and in vitro models,the crucial lipid species in I/R injury were identifed to be oxidized PUFAs enriched phosphatidylethanolamines.Using multi-omics,arachidonic acid 15-lipoxygenase-1(ALOx15)was identified as the primary mediator of ischemia-provoked phospholipid peroxidation,which was further confirmed using chemogenetic approaches.Collectively,our results reveal that ALOx15 induction in the ischemia phase acts as a'burning point'to ignite phospholipid oxidization into ferroptotic signals.This finding characterizes a novel molecular mechanism for myocardial ischemia injury and offers a potential therapeutic target for early intervention of V/R injury. | Xiao-Hui Ma Jiang-Han-Zi Liu Chun-Yu Liu Wan-Yang Sun Wen-Jun Duan Guan Wang Hiroshi Kuriara Rong-Rong He Yi-Fang Li Yang Chen Hongcai Shang | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 11 | Preparation of Ultrafine Starch Particle and its Application in Paper Coating显示文摘Despite its biodegradability, adequate cohesive strength and comparatively low cost, the use of cooked starch as a paper coating binder is limited due to its high viscosity and serious negative impact on the gloss. Starch-based bio-latex with size in the nanometer or sub-micrometer range has been developed recently to overcome these shortcomings. In this study, ultrafine starch particle(UFSP) was prepared by mechanical milling using a DYNO mill in combination with light chemical pretreatment. Model coating colors containing different dosages of UFSP were applied to base paper and the properties of the coated papers were evaluated. The results showed that the UFSP was disc-shaped with a median particle diameter of 167 nm. Water retention capacity of the coating colors was improved considerably with the addition of UFSP, i.e., the water retention value decreased by nearly 40% when styrene-butadiene latex was replaced by UFSP at a dosage of 3 pph(per hundred parts of pigment). The high shear rate viscosities of the coating colors containing no more than 2 pph of USFP were similar to that of the control coating color at shear strain rate higher than 2000 s^(-1). The properties and performances of the coated papers were comparable to the control coated paper with single synthesized latex binder. The gloss and the print gloss of paper samples with or without USFP were 59.7% and 58.2%, 79.0% and 78.8%, respectively. Surface strength of paper samples with or without USFP were 0.96 and 0.90 m/s, respectively, while the ink absorptivity values were 34% and 33%. This study demonstrates a promising approach to obtain submicrometer sized starch for paper coating. | JinGang Liu JiaFu Wang YanFen Du BiSong Wang HongCai Li YanQun Su JingHuan Chen | 2017 | Paper And Biomaterials2017，2，1： | 2 |
| 12 | Research on One-Piece Structure Target Flow Sensing Technology Based on Fiber Bragg Grating显示文摘鉴于在传统的水力的系统的察觉存在的问题,例如大量传感器和低测量精确性,一个新一个片目标类型流动传感器基于纤维布拉格栅栏(FBG ) 被设计并且研究。紧缩的结构被设计,它是方便的基于 FBG 的原则和目标类型流动传感器的结构的分析被拆除,处理,并且安装。在液体流动放的目标的力量被变成 FBG 波长飘移,一种相应关系地。温度和种类的生气敏感上的问题被使用相称性地在伸臂的两表面上粘贴的两倍 FBG 有效地解决。液体状态上的影响在软件通过模拟被分析流畅,并且结果证明影响比传统的结构的小。在水力的系统的实验的结果证明在在双 FBG 中央波长的变化之间有一种好线性关系,在目标表上装载的质量有一种好线性关系,并且敏感是两次单个 FBG 敏感的。 | Chuntong LIU Zhengyi ZHANG Hongcai LI Zhenxin HE Xiaofeng ZHAO Rongjing WU | 2016 | Photonic Sensors2016，6，4： | 2 |
| 13 | Optical Fiber Grating Vibration Sensor for Vibration Monitoring of Hydraulic Pump显示文摘 | Zhengyi ZHANG Chuntong LIU Hongcai LI Zhenxin HE Xiaofeng ZHAO | 2017 | Photonic Sensors2017，7，2： | 1 |
| 14 | Comparison of two earthquake early warning location methods显示文摘According to earthquake catalog records of Fujian Seismic Network, the Tnowmethod and the fourstation continuous location method put forward by Jin Xing are inspected by using P-wave arrival information of the first four stations in each earthquake. It shows that the fourstation continuous location method can locate more seismic events than the Tnowmethod. By analyzing the results, it is concluded that the reason for this is that the Tnowmethod makes use of information from stations without being triggered, while some stations failed to be reflected in earthquake catalog because of discontinuous records or unclear records of seismic phases. For seismic events whose location results can be given, there is no obvious difference in location results of the two methods and positioning deviation of most seismic events is also not significant. For earthquakes outside the network, the positioning deviation may amplify as the epicentral distance enlarges, which may relate to the situation that the seismic stations are centered on one side of epicenter and the opening angle between seismic stations used for location and epicenter is small. | Jun Li Xing Jin Hongcai Zhang Yongxiang Wei | 2013 | Earthquake Science2013，26，1： | 1 |
| 15 | Preparation,model construction and efficacy lipid-lowering evaluation of kiwifruit juice fermented by probiotics显示文摘In this study,kiwi juice was fermented with acid-resistant and bile-resistant probiotics to screen out lactic acid bacteria that can lower cholesterol and were suitable for kiwi fermentation.A non-linear fitting equation was used to establish a kinetic model of probiotics fermenting kiwi juice(R^(2)>0.90),and then a fermented juice with special effects of lowering fat was prepared.We have studied the lipid-lowering effect of fermented fruit juice through in vivo validation experiments in mice,and determined the lipid-lowering effect of fermented fruit juice according to the mouse serum indicators and the distribution of intestinal flora.The results suggested that the juice fermented with Bifidobacterium bifidum 6169 and Lactobacillus plantarum 21805 were more effective in cholesterol degradation,and the cholesterol degradation rates were 67.57%and 64.22%,respectively.The number of viable bacteria after fermentation was significantly higher than other groups(p<0.05),and the sensory score was also higher.In addition,the serum indicators were significantly ameliorated and the number of beneficial microorganisms in the intestinal flora increased after the high-fat mice were treated with fermented kiwifruit juice.The research indicates that the fermented products have a regulatory effect on cholesterol levels in mice with hyperlipidemia. | Yu Wang Hongcai Li Yichen Ren Yaqin Wang Ren Yaopeng Wang Xiaowei Yue Tianli Wang Zhouli Gao Zhenpeng | 2022 | Food Bioscience2022，47，3： | 1 |
| 16 | Earthquake magnitude estimation using the s_c and P_d method for earthquake early warning systems显示文摘Earthquake early warning(EEW) systems are one of the most effective ways to reduce earthquake disaster.Earthquake magnitude estimation is one of the most important and also the most difficult parts of the entire EEW system. In this paper, based on 142 earthquake events and253 seismic records that were recorded by the KiK-net in Japan, and aftershocks of the large Wenchuan earthquake in Sichuan, we obtained earthquake magnitude estimation relationships using the scand Pdmethods. The standard variances of magnitude calculation of these two formulas are ±0.65 and ±0.56, respectively. The Pdvalue can also be used to estimate the peak ground motion of velocity, then warning information can be released to the public rapidly,according to the estimation results. In order to insure the stability and reliability of magnitude estimation results, we propose a compatibility test according to the natures of these two parameters. The reliability of the early warning information is significantly improved though this test. | Xing Jin Hongcai Zhang Jun Li Yongxiang Wei Qiang Ma | 2013 | Earthquake Science2013，26，1： | 1 |
| 17 | Metal-organic frameworks for separations显示文摘 | Li Jianrong Julian Sculley Zhou Hongcai | 2012 | Chemical Reviews2012，112，： | 1 |
| 18 | Implementation of Deutsch-Jozsa algorithm via cavity QED显示文摘 | YANG Rongcan LI Hongcai | 2008 | Journal of Fujian NormalUniversity:Natural Science Edition2008，24，： | 1 |
| 19 | Controllable functionalization of single-wall carbon nanotubes by in situ polymerization method for organic photovoltaic devices显示文摘 | Daqin Yun Wei Feng Hongcai Wu Baoming Li Xiaozheng Liu Wenhui Yi Junfen Qiang Song Gao Shaolin Yan | 2008 | Synthetic Metals2008，，21： | 1 |
| 20 | Gastrodin modified polyurethane conduit promotes nerve repair via optimizing Schwann cells function显示文摘Peripheral nerve regeneration and functional recovery remain a major clinical challenge.Nerve guidance conduit(NGC)that can regulate biological behavior of Schwann cells(SCs)and facilitate axonal regeneration through microenvironmental remodeling is beneficial for nerve regeneration and functional recovery.Gastrodin,a main constituent of a Chinese traditional herbal medicine,has been known to display several biological and pharmacological properties,especially antioxidative,anti-inflammatory and nerve regeneration.Herein,polyurethane(PU)NGCs modified by different weight ratio of Gastrodin(0,1 and 5 wt%)were designed for sequential and sustainable drug release,that created a favorable microenvironment for nerve regeneration.The scaffold showed suitable pore structure and biocompatibility in vitro,and evidently promoted morphological and functional recovery of regenerated sciatic nerves in vivo.Compared to the PU and 1% Gastrodin/PU scaffolds,the 5% Gastrodin/PU significantly enhanced the proliferation,migration and myelination of SCs and up-regulated expression of neurotrophic factors,as well as induction of the differentiation of PC12 cells.Interestingly,the obvious anti-inflammatory response was observed in 5% Gastrodin/PU by reduced expression of TNF-α and iNOS,which also evidenced by the few fibrous capsule formation in the subcutaneous implantation.Such a construct presented a similarity to autograft in vivo repairing a 10 mm sciatic nerve defects.It was able to not only boost the regenerated area of nerve and microvascular network,but also facilitate functional axons growth and remyelination,leading to highly improved functional restoration.These findings demonstrate that the 5% Gastrodin/PU NGC efficiently promotes nerve regeneration,indicating their potential for use in peripheral nerve regeneration applications. | Hongcai Yang Qing Li Limei Li Shaochun Chen Yu Zhao Yingrui Hu Lu wang Xiaoqian Lan Lianmei Zhong Di Lu | 2022 | Bioactive Materials2022，7，2： | 1 |
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