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| 1 | The biological role of the CXCL12/CXCR4 axis in esophageal squamous cell carcinoma显示文摘Esophageal cancer is the eighth most common malignant tumor and the sixth leading cause of cancer-related death worldwide.Esophageal squamous cell carcinoma(ESCC)is the main histological type of esophageal cancer,and accounts for 90%of all cancer cases.Despite the progress made in surgery,chemotherapy,and radiotherapy,the mortality rate from esophageal cancer remains high,and the overall 5-year survival rate is less than 20%,even in developed countries.The C-X-C motif chemokine ligand 12(CXCL12)is a member of the CXC chemokine subgroup,which is widely expressed in a variety of tissues and cells.CXCL12 participates in the regulation of many physiological and pathological processes by binding to its specific receptor,C-X-C motif chemokine receptor type 4(CXCR4),where it causes embryonic development,immune response,and angiogenesis.In addition,increasing evidence indicates that the CXCL12/CXCR4 axis plays an important role in the biological processes of tumor cells.Studies have shown that CXCL12 and its receptor,CXCR4,are highly expressed in ESCC.This abnormal expression contributes to tumor proliferation,lymph node and distant metastases,and worsening prognosis.At present,antagonists and imaging agents against CXCL12 or CXCR4 have been developed to interfere with the malignant process and monitor metastasis of tumors.This article summarizes the structure,function,and regulatory mechanism of CXCL12/CXCR4 and its role in the malignancy of ESCC.Current results from preclinical research targeting CXCL12/CXCR4 are also summarized to provide a reference for the clinical diagnosis and treatment of ESCC. | Xianxian Wu Hongdian Zhang Zhilin Sui Yang Wang Zhentao Yu | 2021 | Cancer Biology & Medicine2021，18，2： | 9 |
| 2 | Synthesis and characterization of a functional polyhedral oligomeric silsesquioxane and its flame retardancy in epoxy resin显示文摘 | Kun Wu Lei Song Yuan Hu Hongdian Lu Baljinder K. Kandola Everson Kandare | 2009 | Progress in Organic Coatings2009，，4： | 2 |
| 3 | Structure characteristics and thermal properties of silane grafted-polyethylene/ clay nanocomposite prepared by reactive extrusion显示文摘 | Lu Hongdian Hu Yuan Li Ming | 2006 | Composites Science and Technology2006，66，： | 1 |
| 4 | Study on intu-mescent flame retarded polystyrene compos-ites with improved flame retardancy 显示文摘 | Lu Hongdian Wilkie Charles A | 2010 | Polymer Degradation and Stability2010，95，： | 1 |
| 5 | Synergistic effect of iron and intumescent flame retardant on shape-stabilized phase change material显示文摘 | Ping Zhang Yuan Hu Lei Song Hongdian Lu Jian Wang Qingqing Liu | 2009 | Thermochimica Acta2009，，1： | 1 |
| 6 | Thermal properties and flammability performance of poly(vinyl alcohol)/α-zirconium phosphates显示文摘 | Lu Hongdian Wilkie C A Ding Ming | | 0，，05： | 1 |
| 7 | Study on intumescent flame retarded polystyrene composites with improved flame retardancy显示文摘 | Lu Hongdian Wilkie Charles A | 2010 | PolymerDegradation and Stability2010，95，： | 1 |
| 8 | Study of the Fire Performance of Magnesium Hydroxide Sulfate Hy- drate Whisker Flame Retardant Polyethylene显示文摘 | Lu Hongdian Hu Yuan Yang Ling | 2004 | Macro- molecular Materials and Engineering2004，289，11： | 1 |
| 9 | Synthesis and characterization of a functional polyhedral oligomeric silsesquioxane and its flame retardancy in epoxy resin显示文摘 | Kun Wu Lei Song Yuan Hu Hongdian Lu Baljinder K. Kandola Everson Kandare | 2009 | Progress in Organic Coatings2009，，4： | 1 |
| 10 | Synergistic Effect of POSS on Mechanical Properties, Flammability, and Thermal Degradation of Intumescent Flame Retardant Polylactide Composites显示文摘 | Xin Wang Shanyong Xuan Lei Song Hongyu Yang Hongdian Lu Yuan Hu | 2012 | Journal of Macromolecular Science, Part B2012，，： | 1 |
| 11 | Morphology, thermal, and mechanical properties of ame-retardant silicone rubber/montmorillonite nanocomposites 显示文摘 | Yang Ling Yuan Hu Lu Hongdian | 2006 | J Appl Polym Sci2006，99，6： | 1 |
| 12 | Study on intumescent flame retarded polystyrene composites with improved flame retar- dancy显示文摘 | Lu Hongdian Charles A Wilkie | 2010 | Polym Degrad Stab2010，，95： | 1 |
| 13 | 显示文摘 | Yang Ling Hu Yuan Lu Hongdian | 2006 | Journal of Applied Polymer Science2006，99，6： | 1 |
| 14 | Of flunarizinein migraine prophylaxis,double blind observation显示文摘 | Wu Baoren Wang Hongdian Ren chiffon | 2010 | Journal of stroke and cerebrovascular diseases2010，8，： | 1 |
| 15 | Synergistic effect of nanoflaky manganese phosphate on thermal degradation and flame retardant properties of intumescent flame retardant polypropylene system显示文摘 | Zhang Ping Song Lei Lu Hongdian | 2009 | Polymer Degradation and Stability2009，94，2： | 1 |
| 16 | Fire performance of flame retardant polypropylene and polyslyrene composiles screened with microscale combustion calorimetry显示文摘 | Lu Hongdian Wilkie Charles A | 2011 | Polym Adv Technol2011，22，： | 1 |
| 17 | Thermal degradation mechanism of flame retarded epoxy resins with a DOPO-substitued organophosphorus oligomer by TG-FTIR and DP-MS显示文摘 | Xin Wang Yuan Hu Lei Song Weiyi Xing Hongdian Lu | 2011 | Journal of Analytical and Applied Pyrolysis2011，，1： | 1 |
| 18 | Thermal properties and flammability performance of poly (vinyl alcohol)/ α-zirconium phosphates显示文摘 | Lu Hongdian Wilkie C A Ding Ming | | 0，，05： | 1 |
| 19 | Study on Intumescent Flame Retarded Polystyrene Composites with Improved Flame Retardancy显示文摘 | Hongdian Lu Charles A Wilkie | 2010 | Polymer Degradation and Stability2010，95，12： | 1 |
| 20 | Synthesis and characterization of a DOPO-substitued organophosphorus oligomer and its application in flame retardant epoxy resins显示文摘 | Xin Wang Yuan Hu Lei Song Hongyu Yang Weiyi Xing Hongdian Lu | 2011 | Progress in Organic Coatings2011，，1： | 1 |
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