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| 1 | Inhibition and recovery of nitrification in treating real coal gasification wastewater with moving bed biofilm reactor显示文摘Moving bed biofilm reactor (MBBR) was used to treat real coal gasification wastewater. Nitrification of the MBBR was inhibited almost completely during start-up period. Sudden increase of influent total NH 3 concentration was the main factor inducing nitrification inhibition. Increasing DO concentration in the bulk liquid (from 2 to 3 mg/L) had little effect on nitrification recovery. Nitrification of the MBBR recovered partially by the addition of nitrifying sludge into the reactor and almost ceased within 5 days. Nitrification ratio of the MBBR achieved 65% within 12 days by increasing dilute ratio of the influent wastewater with tap water. The ratio of nitrification decreased to 25% when influent COD concentration increased from 650 to 1000 mg/L after nitrification recovery and recovered 70% for another 4 days. | Huiqiang Li Hongjun Han Maoan Du Wei Wang | 2011 | Journal of Environmental Sciences2011，23，4： | 34 |
| 2 | Enhanced anaerobic biodegradability of real coal gasification wastewater with methanol addition显示文摘Coal gasification effluent is a typical refractory industrial wastewater with a very poor anaerobic biodegradability due to its toxicity.Methanol was introduced to improve anaerobic biodegradability of real coal gasification wastewater,and the effect of methanol addition on the performance was investigated in a mesophilic upflow anaerobic sludge bed reactor with a hydraulic retention time of 24 hr.Experimental results indicated that anaerobic treatment of coal gasification wastewater was feasible with the addition of methanol.The corresponding maximum COD and phenol removal rates were 71% and 75%,respectively,with methanol concentration of 500 mg COD/L for a total organic loading rate of 3.5 kg COD/(m3 ·day) and a phenol loading rate of 0.6 kg/(m3 ·day).The phenol removal rate was not improved with a higher methanol concentration of 1000 mg COD/L.Substrate utilization rate (SUR) tests indicated that the SURs of phenol were 106,132,and 83 mg phenol/(g VSS·day) at methanol concentrations of 250,500,and 1000 mg COD/L,respectively,and only 45 mg phenol/(g VSS·day) in the control reactor.The presence of methanol could reduce the toxicity of coal gasification wastewater and increase the biodegradation of phenolic compounds. | Wei Wang,Hongjun Han,Min Yuan,Huiqiang Li State Key Laboratory of Urban Water Resource and Environment,Harbin Institute of Technology,Harbin 150090,China | 2010 | Journal of Environmental Sciences2010，22，12： | 25 |
| 3 | Nitrogen removal and simultaneous nitrification and denitrification in a fluidized bed step-feed process显示文摘For urban wastewater treatment,we conducted a novel four-stage step-feed wastewater treatment system combined with a fluidized bed laboratory experiment to investigate chemical oxygen demand(COD),NH4+-N,and total nitrogen(TN) removal performance.The removal rates of COD,NH4+-N and TN were 88.2%,95.7%,and 86.4% with e?uent concentrations of COD,NH4+-N and TN less than 50,8,and 10 mg/L,respectively.Biomass and bacterial activities were also measured,with results showing more nitrobacteria in the activated sludge than in the biofilm;however,bacterial activity of the biofilm biomass and the activated sludge were similar.Nitrogen concentrations during the process were also detected,with simultaneous nitrification and denitrification found to be obvious. | BingWang Wei Wang Hongjun Han Hongbo Hu Haifeng Zhuang | 2012 | Journal of Environmental Sciences2012，24，2： | 22 |
| 4 | Activation flotation and mechanism of lime-depressed pyrite with oxalic acid显示文摘Flotation tests, contact angle measurements, infrared spectrum analyses, X-ray analyses and computer simulation were carried out in order to study the activation mechanism of lime-depressed pyrite with oxalic acid. The results show that the oxalic acid effectively eliminated the hydrophilic calcium film from the surface of pyrite. Therefore, the efficiency of pyrite flotation was also activated. The results indicate that after reacting with hydrophobic insoluble remainders on the surface of pyrite, oxalic acid can produce hydrophilic compounds, such as CaCO 3 , Ca(OH) 2 and Fe(OH) 3 . As a consequence, a fresh pyrite layer was exposed and its flotation activated. | Huang Hongjun Hu Yuehua Sun Wei | 2012 | International Journal of Mining Science and Technology2012，22，1： | 15 |
| 5 | Effect of Liandouqingmai Recipe on life quality and vascular endothelial injury in patients with coronary heart disease显示文摘OBJECTIVE:To observe the effects of Liandouqingmai Recipe on life quality and vascular endothelial injury in patients with coronary heart disease.METHODS:Capitalized 101 patients with coronary heart disease were randomly divided into a treatment group(n=45) treated with Liandouqingmai Recipe and a standard treatment group(control group,n=56).A normal group of 16 healthy persons was additionally set up.Changes in ET-1 and NO levels were measured and Seatle Angina Questionnaire(SAQ) was adopted in studying life quality before and after treatment for two weeks.The data were analyzed with SPSS 16.0 statistic software.RESULTS:The average level of ET-1 in the normal group was lower and NO higher than that of patients with coronary heart disease.There was no significant difference in the average level of ET-1 and NO and in the scores of SAQ [physical limitation(PL),pngina stability(AS),apngina frequency(AF),treatment satisfaction(TS) and disease perception(DP)] between the two groups before treatment(P>0.05).But after treatment,the scores of SAQ(PL,AS,AF,TS,DP) and NO level were higher than those in the control group,and ET-1 average level in the treatment group was lower than that in the control group.The negative relations between PL and ET-1 and between AF and ET-1 were found in this study.CONCLUSION:Liandouqingmai Recipe can raise scores of SAQ and NO level and decline ET level in patients with coronary heart disease on the basis of convertional standard treatment,thus improving vascular endothelial function and life quality.Life quality is related to vascular endothelial function. | Hongjun Zhu Shu Lu Wei Su Shaoyu Gong Zhibin Zhang Ping Li | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 10 |
| 6 | Genome-wide Dissection of Co-selected UV-B Responsive Pathways in the UV-B Adaptation of Qingke显示文摘Qingke (Tibetan hulless barley) has long been cultivated and exposed to long-term and strong UV-B radiation on the Tibetan Plateau, which renders it an ideal species for elucidating novel UV-B responsive mechanisms in plants. Here we report a comprehensive metabolite profiling and metabolite-based genome-wide association study (mGWAS) using 196 diverse qingke and barley accessions. Our results demonstrated both constitutive and induced accumulation, and common genetic regulation, of metabolites from different branches of the phenylpropanoid pathway that are involved in UV-B protection. A total of 90 significant mGWAS loci for these metabolites were identified in barley-qingke differentiation regions, and a number of high-level metabolite trait alleles were found to be significantly enriched in qingke, suggesting co-selection of various phenylpropanoids. Upon dissecting the entire phenylpropanoid pathway, we identified some key determinants controlling natural variation of phenylpropanoid content, including three novel proteins, a flavone C-pentosyltransferase, a tyramine hydroxycinnamoyl acyltransferase, and a MYB transcription factor. Our study, furthermore, demonstrated co-selection of both constitutive and induced phenylpropanoids for UV-B protection in qingke. | Xingquan Zeng Hongjun Yuan Xuekui Dong Meng Peng Xinyu Jing Qijun Xu Tang Tang Yulin Wang Sang Zha Meng Gao Congzhi Li Chujin Shu Zexiu Wei Wangmu Qimei Yuzhen Basang Jiabu Dunzhu Zeqing Li Lijun Bai Jian Shi Zhigang Zheng Sibin Yu Alisdair R.Fernie Jie Luo Tashi Nyima | 2020 | Molecular Plant2020，13，1： | 9 |
| 7 | Review of Chinese atmospheric science research over the past 70 years: Synoptic meteorology显示文摘Synoptic meteorology is a branch of meteorology that uses synoptic weather observations and charts for the diagnosis,study,and forecasting of weather.Weather refers to the specific state of the atmosphere near the Earth’s surface during a short period of time.The spatial distribution of meteorological elements in the atmosphere can be represented by a variety of transient weather phenomena,which are caused by weather systems of different spatial and temporal scales.Weather is closely related to people’s life,and its development and evolution have always been the focus of atmospheric scientific research and operation.The development of synoptic meteorology is closely related to the development of observation systems,dynamical theories and numerical models.In China,observation networks have been built since the early 1950 s.Up to now,a comprehensive meteorological observation systembased on ground,air and space has been established.In particular,the development of a new generation of dense radar networks,the development of the Fengyun satellite series and the implementation of a series of large field experiments have brought our understanding of weather from large-scale environment to thermal dynamics,cloud microphysical structure and evolution characteristics of meso and micro-scale weather systems.The development of observation has also promoted the development of theory,numerical model and simulation.In the early days,China mainly used foreign numerical models.Lately,China has developed numerical model systems with independent intellectual property rights.Based on the results of high-resolution numerical simulations,in-depth understanding of the initiation and evolution mechanism and predictability of weather at different scales has been obtained.Synoptic meteorology has gradually changed from an initially independent development to a multidisciplinary approach,and the interaction between weather and the change of climate and environment has become a hot and frontier topic in atmospheric science.This paper reviews the important scientific and technological achievements made in China over the past 70 years in the fields of synoptic meteorology based on the literatures in China and abroad,from six aspects respectively including atmospheric dynamics,synoptic-scale weather,typhoon and tropical weather,severe convective weather,numerical weather prediction and data assimilation,weather and climate,atmospheric physics and atmospheric environment. | Zhiyong MENG Fuqing ZHANG Dehai LUO Zhemin TAN Juan FANG Jianhua SUN Xueshun SHEN Yunji ZHANG Shuguang WANG Wei HAN Kun ZHAO Lei ZHU Yongyun HU Huiwen XUE Yaping MA Lijuan ZHANG Ji NIE Ruilin ZHOU Sa LI Hongjun LIU Yuning ZHU | 2019 | Science China Earth Sciences2019，62，12： | 7 |
| 8 | In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model显示文摘The urokinase-type plasminogen activator(uPA)loaded hollow nanogels(nUK)were synthesized by a one-step reaction of glycol chitosan and aldehyde capped poly(ethylene oxide).The resultant formulation is sensitive to diagnostic ultrasound(US)of 2 MHz.Herein,we evaluated the in vivo sonothrombolysis performance of the nUK on acute ischemic stroke rat model which was established by suture embolization of middle cerebral artery(MCA).Via intravenous(i.v.)administration,the experimental data prove a controlled release of the therapeutic protein around the clots under ultrasound stimulation,leading to enhanced thrombolysis efficiency of the nUK,evidenced from smaller infarct volume and better clinical scores when compared to the i.v.dose of free uPA no matter with or without US intervention.Meanwhile,the preservation ability of the nanogels not only prolonged the circulation duration of the protein,but also resulted in the better blood-brain barrier protection of the nUK formulation,showing no increased risk on the hemorrhagic transformation than the controls.This work suggests that the nUK is a safe sonothrombolytic formulation for the treatment of acute ischemic stroke. | Yuming Teng Haiqiang Jin Ding Nan Mengnan Li Chenghe Fan Yuanyuan Liu Pu Lv Wei Cui Yongan Sun Hongjun Hao Xiaozhong Qu Zhenzhong Yang Yining Huang | 2018 | Bioactive Materials2018，3，1： | 7 |
| 9 | Apropos:critical analysis of molluscicide application in schistosomiasis control programs in Brazil显示文摘Schistosomiasis is a snail-transmitted infectious disease affecting over 200 million people worldwide.Snail control has been recognized as an effective approach to interrupt the transmission of schistosomiasis,since the geographic distribution of this neglected tropical disease is determined by the presence of the intermediate host snails.In a recent Scoping Review published in Infectious Diseases of Poverty,Coelho and Caldeira performed a critical review of using molluscicides in the national schistosomiasis control programs in Brazil.They also described some chemical and plant-derived molluscicides used in China.In addition to the molluscicides described by Coelho and Caldeira,a large number of chemicals,plant extracts and microorganisms have been screened and tested for molluscicidal actions against Oncomelania hupensis,the intermediate host of Schistosoma japonicum in China.Here,we presented the currently commercial molluscicides available in China,including 26%suspension concentrate of metaldehyde and niclosamide(MNSC),25%suspension concentrate of niclosamide ethanolamine salt(SCNE),50%niclosamide ethanolamine salt wettable powder(WPN),4%niclosamide ethanolamine salt dustable powder(NESP),5%niclosamide ethanolamine salt granule(NESG)and the plant-derived molluscicide“Luowei”.These molluscicides have been proved to be active against O.hupensis in both laboratory and endemic fields,playing an important role in the national schistosomiasis control program of China.Currently,China is transferring its successful experiences on schistosomiasis control to African countries.The introduction of Chinese commercial molluscicides to Africa,with adaptation to local conditions,may facilitate the progress towards the elimination of schisosomiasis in Africa. | Hongjun Li Wei Wang | 2017 | Infectious Diseases of Poverty2017，6，1： | 6 |
| 10 | Effect of 2-aminothiophenol on the separation of jamesonite and marmatite显示文摘The minerals jamesonite and marmatite have similar surface properties.Separating them using a flotation method is inefficient.For separation of lead and zinc the lead mineral is generally floated preferentially to the zinc mineral,which appears in the sinks.In this study a new of collector,2-aminothiophenol,is introduced that can float a zinc mineral,as a product entrapped in foam,preferentially.Single mineral flotation tests revealed that 2-aminothiophenol has good selectivity for flotation of marmatite. An artificial mixture of minerals used in a flotation test showed that 2-aminothiophenol can effectively separate marmatite from jamesonite.A product assaying at 45.06%Zn and 4.06%Pb was produced.FTIR spectra were employed to probe the adsorption mechanism of 2-aminothiophenol onto marmatite.The results indicate that adsorption of 2-aminothiophenol onto jamesonite and marmatite were,respectively,physical adsorption and chemical adsorption.This agrees with the flotation results. | HUANG Hongjun SUN Wei | 2010 | Mining Science and Technology2010，20，3： | 5 |
| 11 | Immunodiagnostic efficacy of detection of Schistosoma japonicum human infections in China:a meta analysis显示文摘Objective:To assess the diagnostic efficacy of the currently most widely used indirect hemagglutination assay(IHA) and enzyme-linked immunosorbent assay(ELISA) for detection of Schistosoma japonicum human infections.Methods:A comprehensive search was undertaken from China National Knowledge Infrastructure,Wanfang Database.VIP Database,PubMed. Cochrane Library,Science Citation Index Expanded.Proquest,and the inclusion and exclusion criteria were strictly settled.The funnel plot was used to assess the publication bias.Cochran’s Q test was employed to measure the homogeneity between studies,a summary receiver operating characteristic(SROC) curve was used to compare the diagnostic accuracy between the IHA and ELISA qualitatively by means of the Weighted Least Square method,the Ordinary Least Square method and the Robust regression method,and the diagnostic odds ratio(DOR) was drawn to compare the accuracy quantitatively.Results:Out of 785 publications,19 papers were eventually selected for analysis.Literature finality assessment indicated that minor publication bias existed in studies pertaining IHA test,but no bias was found in literatures regarding ELISA test.The heterogeneity test showed a heterogeneity between studies was present(χ~2 =466.07 and 34.67. both P values<0.0001).The areas under the SROC curves of IHA were all higher than that of ELISA test using the three methods(Weighted Least Square method:0.766 vs.0.695.Ordinary Least Square method:0.826 vs.0.741.Robust regression:0.815 vs.0.715).The TPR* values for IHA and EUSA were 0.710.0.759.0.749.and 0.650.0.686 and 0.666.respectively,and OR values were 5.997.9.937.8.893.and 3.432.4.784 and 3.959.respectively.The DOR of IHA was 9.41(95% CI:4.88-18.18).and 4.78(95%CI:3.21-7.13) for ELISA.Conclusions:All above results revealed that the diagnostic performance of IHA is better than that of ELISA.However,taking into account their unsatisfactory diagnostic value in areas with low infection intensity,a search for a better diagnostic test that can be applied in field situations in China should be given high priority. | Wei Wang Youzi Li Hongjun Li Yuntian Xing Guoli Qu Jianrong Dai Yousheng Liang | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，1： | 4 |
| 12 | Baicalin inhibits colistin sulfate-induced apoptosis of PC12 cells显示文摘Baicalin,a type of flavonoid extracted from the dried root of Scutellaria baicalensis georgi,has been shown to effectively inhibit cell apoptosis.Therefore,we assumed that baicalin would suppress colistin sulfate-induced neuronal apoptosis.PC12 cells exposed to colistin sulfate(62.5–500μg/mL)for 24 hours resulted in PC12 cell apoptosis.In addition,caspase-3 activity,lactate dehydrogenase level and free radical content increased in a dose-dependent manner.Subsequently,PC12 cells were pretreated with baicalin(25,50 and 100μg/mL),and exposed to 125μg/mL colistin sulfate.Cell morphology markedly changed,and cell viability increased.Moreover,caspase-3 activity,lactate dehydrogenase level and free radical content decreased.Results indicated that baicalin inhibited colistin sulfate-induced PC12 cell apoptosis by suppressing free radical injury,and reducing caspase-3 activity and lactate dehydrogenase activity. | Hong Jiang Pengfei Lv Jichang Li Hongjun Wang Tiezhong Zhou Yingzi Liu Wei Lin | 2013 | Neural Regeneration Research2013，8，28： | 4 |
| 13 | Marek's disease virus VP22 enhances potentially the immune response of E SAT-6/CFP-10 against Mycobacterium bovis infection显示文摘对 Mycobacterium bovis 的当前可得到的疫苗,肺结核的原因的代理人,别提供可靠功效,因此对有改进功效的一支新奇疫苗有需要。这里,我们使用蛋白质 transduction 技术交付直接表示 mycobacterial 抗原指向房间的 DNA 疫苗。我们使用了包括 VP22 的领域(PTD ) 蛋白质从 Marek 的疾病病毒 serotype 结合的各种各样的蛋白质 transduction 1 (MDV-1 ) ,作为为编码抗原的 DNA 构造的交货系统,早能分泌的 antigenic target-6 kDa (ESAT-6 ) 蛋白质和文化过滤蛋白质 10 (CFP-10 ) M。bovis。真核细胞的表示 plasmid pZ106,编码抗原 ESAT-6 和 CFP-10,结合了到各种各样的 PTD,被用来构造试验性的准备。我们的调查结果与 CFP-10 独自或在联合表明了那 VP22 : ESAT-6 熔化蛋白质能传播进包围 transfected 房间的房间单层的所有原子核。而激活 trans transcriptional PTD 出现了,熔化蛋白质和 8R 肽的有限交货是不能的交付熔化蛋白质进任何 untransfected 房间。我们证明了有熔化到 VP22 的准备的那免疫导致更高的抗体和干扰素 -- titer (P < 0.05 ) 。一起拿,我们的结果证明 MDV-1 VP22 用 DNA 疫苗在基因治疗和免疫用作潜在的有免疫力的 enhancer,为 M 的预防提供一条新奇途径。bovis 感染。 | Hongjun Chen Wei Wang Cuiping Song Shengqing Yu Chan Ding | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 4 |
| 14 | Genetic analysis of fertility restoring genes for AL-type male sterility in wheat显示文摘In order to screen molecular markers linked to fertility restoring genes and further improve the breeding efficiency of restorer lines,in this study,wheat varieties 18A,18B and 99AR144-1 were used as experimental materials to establish F2 fertility-segregating population. Plant quantitative trait'major gene + polygene mixed model'separation analysis method and simple sequence repeat(SSR) molecular markers were adopted for genetic analysis of four generations,including the parents(P1 and P2),and hybrid(Fl and F2) populations. The results show that AL-type fertility restoring gene is controlled by two pairs of additive-dominant-epistatic genes and additive-dominant polygene;two primers linked to fertility restoring genes were selected by SSR molecular markers, including Xgwm95 on chromosome 2A and Barc61 on chromosome 1B,with the linkage distance of 15.0 cM and 18.0 cM,respectively. Based on verification,these two markers are reliable for distinguishing AL-type wheat sterile lines and restorer lines. | Liu Xiaofang Tian Xiaoming Nie Yingbin Mu Peiyuan Han Xinnian Sang Wei Cui Fengjuan Xu Hongjun Xiang Jishan | 2013 | Engineering Sciences2013，11，5： | 4 |
| 15 | Distributed disturbance-observer-based vibration control for a flexible-link manipulator with output constraints显示文摘The issue of output constraints is studied for a flexible-link manipulator in the presence of unknown spatially distributed disturbances. The manipulator can be taken as an Euler-Bernoulli beam and its dynamic is expressed by partial differential equations. On account of the uncertainty of disturbances, we present a disturbance observer to estimate infinite dimensional disturbances on the beam. The observer is proven exponentially stable. Considering the problem of output constraints in the practical engineering, we propose a novel distributed vibration controller based on the disturbance observer to fulfill the position regulation of the joint angle and suppress elastic deflections on the flexible link, while confining the regulating errors of output in a suitable scope that we can assign. The closed-loop system is demonstrated exponentially stable based on an integral-barrier Lyapunov function. Simulations validate the effectiveness of the design scheme. | YANG HongJun LIU JinKun HE Wei | 2018 | Science China(Technological Sciences)2018，61，10： | 4 |
| 16 | Pathological features of COVID-19-associated lung injury:a preliminary proteomics report based on clinical samples显示文摘The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality.However,the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown.To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach,fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia.After virus inactivation,a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues.We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism,blood coagulation,immune response,angiogenesis,and cell microenvironment regulation.Several inflammatory factors were upregulated,which was possibly caused by the activation of NF-κB signaling.Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered.Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection,and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic. | Ling Leng Ruiyuan Cao Jie Ma Danlei Mou Yunping Zhu Wei Li Luye Lv Dunqin Gao Shikun Zhang Feng Gong Lei Zhao Bintao Qiu Haiping Xiang Zhongjie Hu Yingmei Feng Yan Dai Jiang Zhao Zhihong Wu Hongjun Li Wu Zhong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 17 | Effect of Liandouqingmai recipe on quality of life and inflammatory reactions of patients with coronary heart disease显示文摘OBJECTIVE: To observe the effect of Liandouqingmai recipe(Chinese herbal medicine compound preparation) on the quality of life(QOL) and inflammatory reaction of patients with coronary heart disease(CHD).METHODS: A total of 101 CHD patients were randomized into two groups: treatment group(n=45)receiving standard treatment for CHD plus Liandouqingmai recipe, and control group(n=56) receiving standard treatment only. The control group contained 16 normal healthy subjects. Changes in hs-C-reactive protein(CRP), peripheral blood leucocytes(PBL), and interleukin(IL)-6 and IL-10 levels were measured. The Seattle Angina Questionnaire(SAQ) was used to determine patient QOL before and after treatment for 2 weeks.RESULTS: Before treatment, SAQ scores [physical limitation(PL), angina stability(AS), angina frequen-cy(AF), treatment satisfaction(TS), and disease perception(DP)] were not statistically different between groups. After treatment, AS and DP levels of controls were significantly increased compared with the other groups, while PL, AS, AF, TS, and DP levels of the treatment group were significantly increased compared with controls. Treatment group SAQ scores(PL, AS, AF, TS, and DP) were significantly higher than for controls. CHD patient IL-6 and IL-10 levels were significantly higher than controls.Before treatment, mean levels of IL-6, hs-CRP and PBL of the two groups were not statistically different. After treatment, mean levels of IL-6, IL-10,hs-CRP and PBL of the two groups were significantly decreased compared with their before treatment values, and levels of IL-6, hs-CRP, and PBL of the treatment group were lower than controls. Although mean IL-10 levels of both groups decreased, there was no significant difference in between-group and in-group comparisons before and after treatment. Mean levels of IL-6 and IL-10 in the normal group were lower than in CHD patients.SAQ scores of QOL were negatively associated with the inflammatory index(IL-6/IL-10), and there was a significant negative association of IL-10 with AS(r=﹣0.15, P<0.05).CONCLUSION: Inflammatory reactions in CHD patients are related to angina status. Coadministration of CHD standard treatment and Liandouqingmai recipe increased patient SAQ scores by decreasing IL-6, IL-10, hs-CRP, and PBL levels in CHD patients, which might inhibit endothelial inflammation to improve patient QOL. | Hongjun Zhu Shu Lu Wei Su Shaoyu Gong Zhibin Zhang Ping Li | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 3 |
| 18 | Defective molybdenum sulfide quantum dots as highly active hydrogen evolution electrocatalysts显示文摘铝二硫化物(瞬间 2), 为有二维的分层的结构的氢进化反应的有希望的非宝贵的 electrocatalyst,接受了在最近的年里增加注意。它的 electrocatalytic 表演被低活跃地点内容和差的电导率限制了。此处,我们报导一个灵巧、一般的 ultrafast 激光脱离方法综合为 electrocatalytic 的瞬间 2 量点(MS-QDs ) 她与充分暴露的活跃地点和高度提高的电导率。MS-QDs 被相应体积材料的 ultrafast 激光脱离在水的答案,他们部分在期间被氧化并且形成了有缺点的结构准备。同样准备的 MS-QDs 在 electrocatalytic 表明了高活动和稳定性她的由于他们的很大的表面区域,有缺点的结构,许多活跃地点,和高电导率。现在的 MS-QDs 能也在光学发现申请,察觉到,精力存储,和变换技术。 | Gang Ou Peixun Fan Xiaoxing Ke Yushuai Xu Kai Huang Hehe Wei Wen Yu Hongjun Zhang Minlin Zhong Hui Wu Yadong Li | 2018 | Nano Research2018，11，2： | 3 |
| 19 | Dissection of heterosis for yield and related traits using populations derived from introgression lines in rice显示文摘Despite the great success achieved by the exploitation of heterosis in rice,the genetic basis of heterosis is still not well understood.We adopted an advanced-backcross breeding strategy to dissect the genetic basis of heterosis for yield and eight related traits.Four testcross(TC) populations with 228 testcross F1 combinations were developed by crossing57 introgression lines with four types of widely used male sterile lines using a North Carolina II mating design.Analysis of variance indicated that the effects of testcross F1 combinations and their parents were significant or highly significant for most of the traits in both years,and all interaction effects with year were significant for most of the traits.Positive midparent heterosis(HMP) was observed for most traits in the four TC populations in the two years.The relative HMPlevels for most traits varied from highly negative to highly positive.Sixty-two dominant-effect QTL were identified for HMPof the nine traits in the four TC populations in the two years.Of these,22 QTL were also identified for the performance of testcross F1.Most dominant-effect QTL could individually explain more than 10% of the phenotypic variation.Four QTL clusters were observed including the region surrounding the RM9–RM297 region on chromosome 1,the RM110–RM279–RM8–RM5699–RM452 region on chromosome 2,the RM5463 locus on chromosome 6 and the RM1146–RM147 region on chromosome 10.The identified QTL for heterosis provide valuable information for dissecting the genetic basis of heterosis. | Chao Xiang Hongjun Zhang Hui Wang Shaobo Wei Binying Fu Jiafa Xia Zefu Li Yongming Gao Guoyou Ye | 2016 | The Crop Journal2016，4，6： | 3 |
| 20 | Screening and evaluation of antioxidants from lees by micro-injector systems combined with a fluorescent probe,N-borylbenzyloxycarbonyl-3,7-dihydroxyphenoxazine,in living Drosophila显示文摘Over the past few decades, the determination of antioxidant activity by chemical probe has been widely reported, but in vivo evaluation via model organisms of Drosophila melanogaster and rapid discovery system has not been studied adequately. In this study, we determined the antioxidant activity of lees and demonstrated the ability of compounds in lees to scavenge H_2O_2 in vitro and in vivo by different chemical probes. Lees increased the ability of Drosophila against oxidative stress and antioxidant enzyme activity in vivo. Five ingredients of organic acids and flavones in lees extract that rapidly scavenged H_2O_2 were revealed by a post-column-derived HPLC-UV-FLD system based on 4-hydroxyphenylacetic acid(PHPAA)chemiluminescence. Additionally, another fluorescent probe,N-borylbenzyloxycarbonyl-3,7-dihydroxyphenoxazine(NBCD), was selected to evaluate the reactive oxygen species(ROS) scavenging capacity of lees in living Drosophila melanogaster using a microfluidic injection test coupled with microscopic imaging analysis, and similar effects were observed in flies when they were treated with tartaric acid and caffeic acid. The results demonstrated that the novel integrated system was suitable for screening and evaluating antioxidant ingredients from natural products. | Guangcui Chu Dandan Cheng Wenjuan Liu Xuefeng Wang Xiaotao Hou Yuanyuan Hou Hongjun Wei Jiagang Deng Gang Bai | 2018 | Chinese Chemical Letters2018，29，10： | 2 |
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