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| 1 | Well-balanced numerical modelling of non-uniform sediment transport in alluvial rivers显示文摘The last two decades have witnessed the development and application of well-balanced numerical models for shallow flows in natural rivers.However,until now there have been no such models for flows with non-uniform sediment transport.This paper presents a 1D well-balanced model to simulate flows and non-capacity transport of non-uniform sediment in alluvial rivers.The active layer formulation is adopted to resolve the change of bed sediment composition.In the framework of the finite volume Slope Llmiter Centred(SLIC) scheme,a surface gradient method is incorporated to attain well-balanced solutions to the governing equations.The proposed model is tested against typical cases with irregular topography,including the refilling of dredged trenches,aggradation due to sediment overloading and flood flow due to landslide dam failure.The agreement between the computed results and measured data is encouraging.Compared to a non-well-balanced model,the well-balanced model features improved performance in reproducing stage,velocity and bed deformation.It should find general applications for non-uniform sediment transport modelling in alluvial rivers,especially in mountain areas where the bed topography is mostly irregular. | Honglu Qian Zhixian Cao Gareth Pender Huaihan Liu Peng Hu | 2015 | International Journal of Sediment Research2015，30，2： | 4 |
| 2 | Cell-nucleus structured electrolyte for low-temperature aqueous zinc batteries显示文摘Rechargeable aqueous zinc(Zn) batteries hold great promise for large-scale energy storage,but their implementation is plagued by poor Zn reversibility and unsatisfactory low-temperature performance.Herein,we design a cell-nucleus structured electrolyte by introducing low-polarity 1,2-dimethoxyethane(DME) into dilute 1 M zinc trifluoromethanesulfonate(Zn(OTf)_(2)) aqueous solution,which features an OTf--rich Zn2^(+)-primary solvation sheath(PSS,inner nucleus) and the DMEmodulated Zn^(2+)-outer solvation sheath(outer layer).We find that DME additives with a low dosage do not participate in the Zn2+-PSS but reinforce the Zn-OTf-coordination,which guarantees good reaction kinetics under ultralow temperatures.Moreover,DME breaks the original H-bonding network of H2O,depressing the freezing point of electrolyte to-52.4℃.Such a cell-nucleus-solvation structure suppresses the H_(2)O-induced side reactions and forms an anion-derived solid electrolyte interphase on Zn and can be readily extended to 1,2-diethoxyethane.The as-designed electrolyte enables the Zn electrode deep cycling stability over 3500 h with a high depth-of-discharge of 51.3% and endows the Zn‖V_(2)O_(5)full battery with stable cycling over 1000 cycles at 40℃.This work would inspire the solvation structure design for low-temperature aqueous batteries. | Yang Dong Ning Zhang Zhaodong Wang Jinhan Li Youxuan Ni Honglu Hu Fangyi Cheng | 2023 | Journal of Energy Chemistry2023，，8： | 2 |
| 3 | A COPII subunit interacting with ER-phagy receptor:a new potential avenue to maintaining neuronal homeostasis显示文摘Endoplasmic reticulum(ER)-associated degradation(ERAD)plays an essential role in protein quality control in the ER.It acts through recognizing misfolded or unassembled proteins and retrotranslocating them across the ER membrane into the cytosol for degradation.ER-phagy,which is an ERAD pathway,also controls the quality and abundance of proteins and organelles by activating ERresident receptors.ER membrane is the important site of initiation for phagophores(crescent-shaped membranes that form and mature into autophagosomes);however,specific sites that are restricted on ER during ER-phagy remain to be identified.Recently,Cui et al.[1]found that a COPII coat subunit,Lstl/SEC24C-Sec23,plays an unconventional role in targeting ER domains for degradation of the ER-phagy receptor,which makes them essential to ER-phagy. | Shifang Huang Mingzhu Tang Honglu Jiang Yuting Li Haoliang Hu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 1 |
| 4 | Anionic formulation of electrolyte additive towards stable electrocatalytic oxygen evolution in seawater splitting显示文摘Hydrogen generation through seawater electrolysis provides a promising,attractive pathway towards the utilization of sustainable energy.However,the catalytic activity and stability of oxygen evolution anode are severely limited by the chloride-induced corrosion and competitive oxidation reactions.In this work,we demonstrate an anion-assisted performance improvement strategy by quick and universal screening of electrolyte additive via correlating Cl-repellency with the anionic properties.Particularly,the addition of phosphate ions is found to enable highly stable alkaline seawater splitting at industry-level current density(0.5 A cm^(-2))over 500 h using transition metal hydroxides as anodic electrocatalysts.In situ experiments and theoretical simulations further reveal that the dynamic anti-corrosion behaviors of surface-adsorbed phosphate ions are attributed to three factors including repelling Cl-ions without significantly blocking OH-diffusion,preventing transition metal dissolution and acting as a local pH buffer to compensate the fast OH-consumption under high current electrolysis. | Meng Yu Jinhan Li Fangming Liu Jiuding Liu Wence Xu Honglu Hu Xijie Chen Weichao Wang Fangyi Cheng | 2022 | Journal of Energy Chemistry2022，31，9： | 1 |
| 5 | Hybrid battery integrated by Zn-air and Zn-Co3O4 batteries at cell level显示文摘The construction of Zn based hybrid battery through the combination of Zn-air and Zn-Co3O4 batteries at cell level is a feasible strategy to integrate high voltage,specific capacity and energy density in one power supply equipment.For Zn based hybrid battery,an efficient cathode material with high specific capacitance and excellent ORR,OER activities is a vital component,which determines its performance in great extent.In this work,with Co based coordination polymer as precursor,oxygen vacancy-rich Co3 O4 based cathode material is synthesized.In this material Co3O4 particles with the size about 20 to 35 nm reside evenly in mesoporous carbon matrix doped by nitrogen atoms.In OER,the overpotential of this cathode material is merely 330 m V.Its ORR proceeds with a typical four electron process with half wave achieving 0.76 V.If charge/discharge at 1 A·g^-1,specific capacitance of this cathode material is 254.4 mAh·g^-1.As current density increases to 20 A·g^-1,the specific capacitance still arrives at 122.5 mAh·g^-1 with nearly 50%retained.Based on attractive performance of this cathode material,Zn based hybrid battery is assembled.When discharge at 1 m A·cm-2,it presences two voltage platforms at 1.71 and 1.14 V.In this situation,specific capacitance reaches 790 m Ah·g^-1 with energy density 928 Wh·kg^-1.Hybrid battery shows promising stability after 300-cycle continuous test. | Ning Liu Honglu Hu Xinxin Xu Qiang Wang | 2020 | Journal of Energy Chemistry2020，29，10： | 1 |
| 6 | Enhanced bed load sediment transport by unsteady flows in a degrading channel显示文摘Laboratory flume experiments were done to investigate bed load sediment transport by both steady and unsteady flows in a degrading channel. The bed, respectively composed of uniform sand, uniform gravel,or sand-gravel mixtures, always undergoes bulk degradation. It is found that both uniform and nonuniform bed load transport is enhanced greatly by unsteady flows as compared to their volumeequivalent steady flows. This enhancement effect is evaluated by means of an enhancement factor, which is shown to be larger with a coarser bed and lower discharges. Also, the fractional transport rates of gravel and sand in non-uniform sand-gravel mixtures are compared with their uniform counterparts under both steady and unsteady flows. The sand is found to be able to greatly promote the transport of gravel, whilst the gravel considerably hinders the transport of sand. Particularly, the promoting and hindering impacts are more pronounced at lower discharges and tend to be weakened by flow unsteadiness. | Zhijing Li Honglu Qian Zhixian Cao Huaihan Liu Gareth Pender Penghui Hu | 2018 | International Journal of Sediment Research2018，33，3： | 1 |
| 7 | Targeting AQP4 localization as a novel therapeutic target in CNS edema显示文摘CNS edema is a pathological phenomenon after trauma, infection, tumor growth, or obstruction of blood supply, and it also can be fatal or lead to long-term disability, psychiatric disorders, substance abuse, or self-harm [1,2]. One exciting possibility would be to control excessive water accumulation in cells. However, all trials that inhibit water channel protein failed in clinic. A recent study by Kitchen et al. [3] reported that targeting the astrocytes’ surface localization of water channel protein aquaporin-4 (AQP4) significantly relieves CNS edema. Astrocytes are the most abundant cell type of the brain and generally have a greater capacity than neurons to survive stresses [4]. Astrocyte cell function is critically affected by the lack of oxygen supply (hypoxia) to the brain, which is usually associated with CNS edema [5]. Their work holds new promise for our ability to use water-transfer strategies to treat CNS edema. Cytotoxic and vasogenic edema are primary interrelated etiological factors for the progress of CNS edema [6]. Vasogenic edema also depends on the extent of cytotoxic edema and the nature/severity of the underlying cause of the cytotoxic edema. So, understanding the pathogenesis of cytotoxic edema is important for the treatment of CNS edema. Aquaporins (AQPs) are historically known to be passive transporters of water. Lines of evidence in the last decade have highlighted the diverse function of AQPs beyond water homeostasis, including regulation of renal water balance, brain-fluid homeostasis, triglyceride cycling, and skin hydration [7]. Moreover, a subgroup of AQP water channels, termed ‘aquaglyceroporins’, also facilitates transmembrane diffusion of small, polar solutes not only water but also solutes [8,9]. AQP4 is the major subtype of AQPs expressed in astrocytes throughout the nervous system and facilitates astroglial cell migration via increasing plasma membrane water permeability, which in turn upregulates the transmembrane water fluxes during astroglial cell movement and is thus considered as an interesting therapeutic target in various neurological disorders. Astrocyte swellingmay also cause cytotoxic component disruptions of the blood–brain barrier, suggesting that astrocytes seem so sensitive to cytotoxic edema. AQP4 is a recognized contributor for the formation of cytotoxic brain edema, which is mainly a phenomenon of intracellular swelling of astrocytes. Knockdown of ‘AQP4’ or removal of the perivascular AQP4 pool by α-syntrophin or α-syntrophin deletion has been convincingly proven to counteract osmotically induced acute brain edema following ischemia and other brain injuries [10–12]. A previous study revealed that the NH2-cytosolic terminus of AQP4 interacts with metabotropic glutamate receptor 5 and assembles with the catalytic subunit of Na,K-ATPase to form a complex that has the potential function for the regulation of water permeability and potassium homeostasis in the astrocytes [13] (Fig. 1). In addition, AQP4 may trigger astrocytic Ca2+ responses, which is partly dependent on autocrine purinergic signaling (P2 purinergic receptor) activation in response to hypoosmotic stress [14] (Fig. 1). Additionally, subcellular relocalization of AQP4 in primary astrocytes is induced by calmodulin (CaM), calcium, and PKA in response to hypotonicity [15]. Further study proved that hypoxia-driven astrocyte swelling induces the increased abundance of AQP4 and initiates AQP4 cell-surface relocalization in a CaM- and PKA-dependent manner [3] (Fig. 1). | Shifang Huang Honglu Jiang Haoliang Hu Deguan Lv | 2021 | Acta Biochimica et Biophysica Sinica2021，53，2： | 0 |
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