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| 1 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 2 | GDNF is abundant in the adult rat gut显示文摘 | PETERS R J OSINSKI M A HONGO J A | 1998 | Journal of the Autonomic Nervous System1998，70，12： | 1 |
| 3 | Heparanase expression is an independent prognostic factor in patients with invasive cervical cancer显示文摘 | Shinyo Y Kodama J Hongo A | 2003 | Ann Oncol2003，14，10： | 1 |
| 4 | Disorders of gastrointestinal motil- ity : towards a new classification 显示文摘 | Wingate D Hongo M Kellow J | 2002 | J Gastrointestinal Hepatol2002，17，： | 1 |
| 5 | Disorders of gastrointestinal motility: Towards a new classification 显示文摘 | Wingate D Hongo M Kellow J | 2002 | J Gastroenterol Hepetol2002，，： | 1 |
| 6 | Role of emmprin in endometrial cancer显示文摘 | Nakamura K Kodama J Hongo A | | 0，，01： | 1 |
| 7 | Identification of the novel developmentally regulated gene, Bdm2, which is highly expressed in fetal rat brain 显示文摘 | NISItINAKA N HONGO S ZHOU C J | 2000 | Brain Res Dev Brain Res2000，120，1： | 1 |
| 8 | The pretreatment of maximum standardized uptake values ( SUVmax ) of the primary tumor is predictor for poor prognosis for patients with epithelial ovarian cancer 显示文摘 | Nakamura K Hongo A Kodama J | 2012 | Aeta Med Okayama2012，66，1： | 1 |
| 9 | Heparanase expression is an independent prognostic factor in patients with invasive cervical cancer 显示文摘 | Shinyo Y Kodama J Hongo A | 2003 | Ann Oncol2003，14，10： | 1 |
| 10 | 1-Gsymbol/s 64-QAM coherent optical transmission over 150 km显示文摘 | HONGO J KASAI K YOSHIDA M | 2007 | IEEE Photonics Technology Letters2007，19，9： | 1 |
| 11 | A newly designed keyhole button 显示文摘 | Koyama J Hongo K Iwashita T | 2000 | J Neurosurg2000，93，3： | 1 |
| 12 | Disorders of gastrointestinal motility:towards a new classification显示文摘 | Wingate D Hongo M | 2002 | J Gastroenterol Hepatol2002，，： | 1 |
| 13 | Biomechanical analysis of a novel locking plate with smooth pegs versus a conventional locking plate with threaded screws for proximal humerus fractures显示文摘 | Yamamoto N Hongo M Berglund L J | 2013 | Journal of Shoulder and Elbow Surger- y2013，22，4： | 1 |
| 14 | A novel type I cytokine re-ceptor is expressed on monocytes, signals proliferation, and acti-vates STAT-3 and STAT-5显示文摘 | Ghilardi N Li J Hongo JA | 2002 | J Biol Chem2002，277，16： | 1 |
| 15 | The role of hepatocyte growth factor activator inhibitor (HAI)-I and HAI-2 in endometrial cancer显示文摘 | Nakamura K Hongo A Kodama J | 2011 | Int J Cancer2011，128，11： | 1 |
| 16 | Vascular endothelial growth factor and platelet-derived endothelial cell growth factor expression are implicated in the angiogenesis of endometrial cancer显示文摘 | Seki N Kodama J Hongo A | 2000 | Eur J Cancer2000，36，： | 1 |
| 17 | Vascular endothelial growth factor and platelet-derived endothelial cell growth factor expression are implicated in the angiogenesis of endometrial cancer显示文摘 | Seki N Kodama J Hongo A | 2000 | Eur J Cancer2000，36，1： | 1 |
| 18 | The pretreatment of maximum standardized uptake values (SUVmax) of the primary tumor is predictor for poor prognosis for patients with epithelial ovarian canner显示文摘 | Nakamura K Hongo A Kodama J | 2012 | Acta Medica Okayama2012，66，1： | 1 |
| 19 | Implication of cartilage intermediate Layer protein in cartilage destruction in subsets ofpatients with osteoarthritis and rheumatoid arthritis显示文摘 | Tsuruha J Masuko - Hongo K Kato T | 2001 | Arthritis Rheum2001，44，： | 1 |
| 20 | Disorders of gastrointestinal motility: towards a new classification 显示文摘 | Wngale D Hongo M KeUow J | 2002 | J Gastroenterol Hepatol2002，，： | 1 |
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