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您的检索式：作者名="Hongqun Gu"
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| 1 | A novel humanized MUC1 antibody–drug conjugate for the treatment of trastuzumab-resistant breast cancer显示文摘Mucin 1(MUC1)has been regarded as an ideal target for cancer treatment,since it is overexpressed in a variety of different cancers including the majority of breast cancer.However,there are still no approved monoclonal antibody drugs targeting MUC1.In this study,we generated a humanized MUC1(HzMUC1)antibody from our previously developed MUC1 mouse monoclonal antibody that only recognizes MUC1 on the surface of tumor cells.Furthermore,an antibody–drug conjugate(ADC)was generated by conjugating HzMUC1 with monomethyl auristatin(MMAE),&the efficacy of HzMUC1-MMAE on the MUC1-positive HER2+breast cancer in vitro&in‘Xenograft’model was tested.Results from western blot analysis&immunoprecipitation revealed that the HzMUC1 antibody did not recognize cell-free MUC1-N in sera from breast cancer patients.Confocal microscopy analysis showed that HzMUC1 antibody bound to MUC1 on the surface of breast cancer cells.Results from mapping experiments suggested that HzMUC1 may recognize an epitope present in the interaction region between MUC1-N and MUC1-C.Results from colony formation assay&flow cytometry demonstrated that HzMUC1-MMAE significantly inhibited cell growth by inducing G2/M cell cycle arrest&apoptosis in trastuzumab-resistant HER2-positive breast cancer cells.Meanwhile,HzMUC1-MMAE significantly reduced the growth of HCC1954 xenograft tumors by inhibiting cell proliferation&enhancing cell death.In conclusion,our results indicate that HzMUC1-ADC is a novel therapeutic drug that can overcome trastuzumab resistance of breast cancer.HzMUC1-ADC should also be an effective therapeutic drug for the treatment of different MUC1-positive cancers in clinic. | Guang Wu Lan Li Yuxin Qiu Wei Sun Tianhao Ren Yingshuai Lv Mengnan Liu Xiaoxia Wang Hongqun Tao Lingjie Zhao Jiawei Cao Licai He Hongzhi Li Haihua Gu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 2 |
| 2 | Ready-to-implement low-carbon retrofit of coal-fired power plants in China:Optimal scenarios selection based on sludge and photovoltaic utilization显示文摘Currently the flexible demand for high proportion penetration of renewable energy depends on coal-fired units(CFUs),and the large-scale phase-out of CFUs in a short time is not realistic in China.Due to urban expansion,approximately 458 Chinese coal-fired power plants(CFPPs)are now located in cities.Limited by space,urban CFUs face difficulty in becoming equipped with carbon capture and storage systems.This presents a sizeable challenge for the low-carbon transition of urban CFPPs and carbon neutral processes.Here,we present a ready-to-implement method to reduce the carbon emission of CFPPs in limited space:roof photovoltaic-assisted power generation combined with sludge cocombustion for coal-fired power generation systems(PVSCs).We also consider nonurban CFPPs with the method of roof photovoltaic-assisted power generation(PVs)only.Based on remaining life cycle analysis,we find that the PVSCs could save 28.47 Mt of coal,reduce CO_(2)emissions by 69.76 Mt,treat 125.70 Mt of sludge,and also generate 12.08 billion RMB worth of electricity revenue per year.In addition,our scenario analysis shows that PVSCs are more profitable when choosing an urban CFU with a remaining life of more than 12 years and while the sludge treatment subsidy is set at 100 RMB t1.Under strict and lenient CFU decommissioning policies,CFUs with a remaining life of between 19 and 30 years and between 13 and 24 years should be selected for PVs,respectively.Thus,we conclude that PVSCs can not only generate economic benefits but also facilitate carbon reduction and solid waste treatment. | Yunchao Xia Jian Deng Bo Hu Qing Yang Jianlan Li Hongqun Gu Guiping Zhou | 2022 | Environmental Science and Ecotechnology2022，，1： | 0 |
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