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| 1 | Inhibition of Proliferation of Prostate Cancer Cell Line DU-145 in vitro and in vivo Using Salvia miltiorrhiza Bunge显示文摘Objective:To investigate the antiproliferative activity of Salvia miltiorrhiza Bunge.(SM)on the castration-resistant prostate cancer(CRPC)cell line DU-145 in vitro and in vivo.Methods:Prostate cancer cell line(DU-145)and normal prostate cell line(RWPE-1)were treated with SM at different concentrations(3.125,12.5,25 and 50μg/mL)to investigate the antiproliferative effects.DNA laddering analysis was performed to investigate the apoptosis of DU-145 cells.Molecular mechanism was investigated by Western blot analysis of p53,Bcl-2,prostate specific antigen(PSA),and androgen receptor(AR).Six-week-old male BALB/c nude mice were randomly divided into normal control group(n=101)and treated group(n=101)which administered 500 mg/kg SM for 2 weeks.Tumor volumes were measured.Results:Treatment with SM resulted in a dose-dependent decrease in cell number of DU-145 cells in comparison with RWPE-1.DNA laddering analysis indicated the apoptosis of DU-145 cells.Treatment with SM increased the expression of p53 and reduced the expression of Bcl-2 proteins.The levels of PSA were considerably reduced in SM-treated group compared to the controls,and a decrease in AR expression was observed when cells were treated with SM in the same pattern as a reduction in PSA.In the tumour xenograft study,SM given once a day for 2 weeks significantly inhibited tumour growth.Conclusion:SM might contribute to the anticancer actions such as induction of apoptosis and inhibition of proliferation of prostate cancer cells. | Woong Jin Bae Jin Bong Choi Kang Sup Kim U Syn Ha Sung Hoo Hong Ji Youl Lee Tae-Kon Hwang Sung Yeoun Hwang WANG Zhi-ping Sae Woong Kim | 2020 | Chinese Journal of Integrative Medicine2020，26，7： | 1 |
| 2 | Antiproliferative Effects of Zinc-Citrate Compound on Hormone Refractory Prostate Cancer显示文摘Objective: To investigate the antiproliferative effects of zinc‐citrate compound on hormone refractory prostate cancer (HRPC). Methods: HRPC cell line (DU145) and normal prostate cell line (RWPE-1) were treated with zinc, citrate and zinc-citrate compound at different time intervals and concentrations to investigate the effect of zinc-citrate compound. Mitochondrial (m)-aconitase activity was determined using aconitase assay. DNA laddering analysis was performed to investigate apoptosis of DU145 cells. Molecular mechanism of apoptosis was investigated by Western blot analysis of P53, P21 waf1 , Bcl-2, Bcl-xL and Bax, and also caspase-3 activity analysis. Results: Treatment with zinc-citrate compound resulted in a time-and dose-dependent decrease in cell number of DU145 cells in comparison with RWPE-1. M-aconitase activity was significantly decreased. DNA laddering analysis indicated apoptosis of DU145 cells. Zinc-citrate compound increased the expression of P21 waf1 and P53, and reduced the expression of Bcl-2 and Bcl-xL proteins but induced the expression of Bax protein. Zinc-citrate compound induced apoptosis of DU145 cells by activation of the caspase-3 pathway. Conclusion: Zinc-citrate compound can induce apoptotic cell death in DU145, by caspase-3 activation through up-regulation of apoptotic proteins and down-regulation of antiapoptotic proteins. | Hoo Hong Yong Sun Choi Hyuk Jin Cho Ji Youl Lee Joon Chul Kim Tae Kon Hwang Sae Woong | 2012 | Chinese Journal of Cancer Research2012，24，2： | 1 |
| 3 | Comparison of Three Types of Stress Urinary Incontinence Rat Models: Electrocauterization, Pudendal Denervation and Vaginal Distension显示文摘 | Sung Hoo Hong Shuyu Piao In Gul Kim Ji Young Lee Hyuk Jin Cho Sae Woong Kim Tae-Kon Hwang Ji Youl Lee | 2012 | Urology2012，，： | 1 |
| 4 | Prevalence of anxiety among gestational diabetes mellitus patients: A systematic review and meta-analysis显示文摘BACKGROUND A diagnosis of gestational diabetes mellitus(GDM)negatively influences maternal mental health.There is a lack of systematic review and meta-analysis on prevalence of anxiety among GDM women.AIM To pool data from existing literature to determine the pooled estimates for the prevalence of anxiety among women diagnosed with GDM.METHODS We searched multiple databases including MEDLINE,Cinahl,PubMed and Scopus to identify studies published up to 31 October 2019 with data on the prevalence of anxiety among women diagnosed with GDM.Data were extracted from published reports.Estimates were pooled using random-effects metaanalyses.RESULTS We reviewed 19 abstracts,retrieved 10 articles and included three studies incorporating 12744 GDM women from three countries.The pooled prevalence of anxiety was 29.5%(95%CI:6.9,52.0)among GDM women.CONCLUSION Prevalence of anxiety among GDM women was high.We suggest that epidemiological studies on anxiety should be conducted urgently as it merits clinical attention.In addition,it is important to identify factors associated with anxiety among women diagnosed with GDM. | Kai Wei Lee Hong Chuan Loh Seng Choi Chong Siew Mooi Ching Navin Kumar Devaraj Maiza Tusimin Habibah Abdul Hamid Fan Kee Hoo | 2020 | World Journal of Meta-Analysis2020，8，3： | 1 |
| 5 | High dosage sildenafilinduces hearing impairment in mice显示文摘 | Bin Na Hong Tae Hoo Yi Sun Yeou Kim | 2008 | Biol Pharm Bull2008，31，10： | 1 |
| 6 | Effect of caustic refining, solvent refining and steam refining on the deacidification and color of rice bran oil显示文摘 | Sun Ki Kim Chul Jin Kim Hong Sik Cheigh Suk Hoo Yoon | 1985 | Journal of the American Oil Chemists’ Society1985，，10： | 1 |
| 7 | Weave-pattern-dependent fabric piezoelectric pressure sensors based on polyvinylidene fluoride nanofibers electrospun with 50 nozzles显示文摘Wearable pressure sensors having versatile device structures have been extensively investigated to achieve high sensitivity under mechanical stimuli.Here,we introduce piezoelectric pressure sensors based on fabrics woven using polyvinylidene fluoride(PVDF)weft and polyethylene terephthalate(PET)warp yarns with different weave structures:1/1(plain),2/2,and 3/3 weft rib patterns.The dependence of the pressure-sensing performance on the weave pattern is demonstrated with an actual large-scale fabric up to the~2 m scale.An optimized pressure sensor with a 2/2 weft rib pattern produced a high sensitivity of 83 mV N−1,which was 245%higher than that of the 1/1 pattern.The detection performance of the optimal fabric was extensively evaluated with a variety of ambient input sources,such as pressing,bending,twisting,and crumpling,as well as various human motions.Further,a large allfabric pressure sensor with arrayed touch pixel units demonstrated highly sensitive and stable sensing performance. | Da Bin Kim Ju Han Sun Min Sung Min Seong Kim Bo Kyoung Choi Sung Jun Park Hyae Rim Hong Hong Je Choi Byeong Kon Kim Chung Hee Park Jong Hoo Paik Joon-Seok Lee Yong Soo Cho | 2022 | npj Flexible Electronics2022，6，1： | 0 |
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